Analytic Expressions for the Ultimate Intrinsic Signal-to-Noise Ratio and Ultimate Intrinsic Specific Absorption Rate in MRI

Cataloged from PDF version of article.The ultimate intrinsic signal-to-noise ratio is the highest possible signal-to-noise ratio, and the ultimate intrinsic specific absorption rate provides the lowest limit of the specific absorption rate for a given flip angle distribution. Analytic expressions for ultimate intrinsic signal-to-noise ratio and ultimate intrinsic specific absorption rate are obtained for arbitrary sample geometries. These expressions are valid when the distance between the point of interest and the sample surface is smaller than the wavelength, and the sample is homogeneous. The dependence on the sample permittivity, conductivity, temperature, size, and the static magnetic field strength is given in analytic form, which enables the easy evaluation of the change in signal-to-noise ratio and specific absorption rate when the sample is scaled in size or when any of its geometrical or electrical parameters is altered. Furthermore, it is shown that signal-tonoise ratio and specific absorption rate are independent of the permeability of the sample. As a practical case and a solution example, a uniform, circular cylindrically shaped sample is studied. Magn Reson Med 66:846–858, 2011. © 2011 Wiley-Liss, In

Micromachinable ultrasonic leaky wave air transducers

Cataloged from PDF version of article.Ultrasonic air transducers using leaky waves on thin membranes are analyzed using perturbation and normal mode approaches. The transducers utilize the efficient coupling of ultrasonic energy to air through radiation of these leaky wave modes when their phase velocity is close to the sound speed in air. Theoretical results on optimum transducer dimensions and bandwidth estimation show that a minimum conversion loss of 8.7 dB with a 78% fractional bandwidth is possible. Common micromachining materials are shown to be suitable transducer materials and result in feasible devices. This is demonstrated by fabricating a 580 kHz transducer using a silicon membrane bonded to a ring of PZT-5H. With this configuration the transducer is self line focusing. Results of through transmission experiments on silicon and transmission images on paper are reported. © 1998 American Institute of Physic

A new detection method for capacitive micromachined ultrasonic transducers

Cataloged from PDF version of article.Capacitive micromachined ultrasonic transducers (cMUT) have become an alternative to piezoelectric transducers in the past few years. They consist of many small circular membranes that are connected in parallel. In this work, we report; a new detection method for cMUTs. We model the membranes as capacitors and the interconnections between the membranes as inductors. This kind of LC net-work is called an artificial transmission line. The vibrations of the membranes modulate the electrical length of the transmission line, which is proportional to the frequency of the signal through it. By measuring the electrical length of the artificial line at a high RF frequency (in the gigahertz range), the vibrations of the membranes can be detected in a very sensitive manner. Far the devices we measured, we calculated the minimum detectable displacement to be in the order of 10(-5) Angstrom/root Hz with a possible improvement to 10(-7) Angstrom/root Hz

Micromachined two-dimensional array piezoelectrically actuated transducers

Cataloged from PDF version of article.This letter presents micromachined two-dimensional array flextensional transducers that can be used to generate sound in air or water. Individual array elements consist of a thin piezoelectric ring and a thin, fully supported, circular membrane. We report on an optimum design for an individual array element based on finite element modeling. We manufacture the transducer in two-dimensional arrays using planar silicon micromachining and demonstrate ultrasound transmission in air at 2.85 MHz. Such an array could be combined with on-board driving and an addressing circuitry for different applications. © 1998 American Institute of Physic

A sensitive detection method for capacitive ultrasonic transducers

Cataloged from PDF version of article.We report a sensitive detection method for capacitive ultrasonic transducers. Detection experiments at 1.6 MHz reveal a minimum detectable displacement around 2.5 x 10(-4) Angstrom/root Hz. The devices are fabricated on silicon using surface micromachining techniques. We made use of microwave circuit considerations to obtain a good displacement sensitivity. Our method also eliminates the dependence of the sensitivity on the ultrasound frequency, allowing the method to be used at low audio frequency and static displacement sensing applications. (C) 1998 American Institute of Physics

Theory and analysis of electrode size optimization for capacitive microfabricated ultrasonic transducers

Cataloged from PDF version of article.Theoretical analysis and computer simulations of capacitive microfabricated ultrasonic transducers indicate that device performance can be optimized through judicious patterning of electrodes. The conceptual basis of the analysis is that electrostatic force should be applied only where it is most effective, such as at the center of a circular membrane. If breakdown mechanisms are ignored, an infinitesimally small electrode with an infinite bias voltage results in the optimal transducer, A more realistic design example compares the 3-dB bandwidths of a fully metalized transducer and a partially metalized transducer, each tuned with a lossless Butterworth network. It is found that the bandwidth of the optimally metalized device is twice that of the fully metalized device

Surface micromachined capacitive ultrasonic transducers

Cataloged from PDF version of article.The current state of a novel technology, surface microfabricated ultrasonic transducers, is reported. Experiments demonstrating both air and water transmission are presented. Air-coupled longitudinal wave transmission through aluminum is demonstrated, implying a 110 dB dynamic range for transducers at 2.3 MHz in air. Water transmission experiments from 1 to 20 MHz are performed, with a measured 60 dB SNR at 3 MHz. A theoretical model is proposed that agrees well with observed transducer behavior. Most significantly, the model is used to demonstrate that microfabricated ultrasonic transducers constitute an attractive alternative to piezoelectric transducers in many applications

Peptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agents

Cataloged from PDF version of article.Magnetic resonance imaging (MRI) attracts great attention in cellular and molecular imaging due to its non-invasive and multidimensional tomographic capabilities. Development of new contrast agents is necessary to enhance the MRI signal in tissues of interest. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents for signal enhancement as they have revealed extraordinary magnetic properties at the nanometre size and their toxicity level is very low compared to other commercial contrast agents. In this study, we developed a new method to functionalize the surface of SPIONs. Peptide amphiphile molecules are used to coat SPIONs non-covalently to provide water solubility and to enhance biocompatibility. Superparamagnetic properties of the peptide-SPION complexes and their ability as contrast agents are demonstrated. In vitro cell culture experiments reveal that the peptide-SPION complexes are biocompatible and are localized around the cells due to their peptide coating

Systematic literature study of trachea and bronchus morphology in children and adults

Understanding the dimensions of the lower airway is critical for performing respiratory surgery, selecting and designing appropriate airway equipment, and removing aspirated foreign bodies via bronchoscopy, anesthesia, and radiography. The purpose of this study was to analyze the trachea and bronchus morphologically in children and adults, as well as to standardize the data for these structures' measurements. Various databases were reviewed for studies on lower airway dimensions. The criteria for inclusion and exclusion were established. Finally, it was agreed to look into 28 studies that took place between 1984 and 2021. The length of the trachea, its anterior-posterior (AP) and transverse dimensions, the lengths and transverse diameters of the right and left major bronchus, and the subcarinal angle were also investigated in the study. In studies where measurements were performed with different methods and procedures; It was revealed that age and gender were effective in the difference in lower respiratory tract dimensions. The mean values of all parameters were greater in adults than in children, the AP diameter of the trachea in adults was greater than the transverse diameter; In children, it was observed that the transverse diameter was larger than the AP diameter on average, the left main bronchus was longer than the right main bronchus, and the transverse diameter was smaller than the right main bronchus in most of the studies. Was found to be smaller. The articles reviewed for this study revealed that measurements were done using a variety of different procedures and approaches, and the resulting data were inconsistent and could not be standardized. The data collected will be beneficial both conceptually and clinically; we believe that additional comparison research involving children and adults in bigger groups are necessary

High-resolution MRI of deep-seated atherosclerotic arteries using motexafin gadolinium

Purpose: To evaluate the potential of using motexafin gadolinium (MGd) to characterize atherosclerotic plaques of deep-seated arteries with MRI. Materials and Methods: We exposed vascular endothelial cells (EC) and smooth muscle cells (SMC) in vitro to varying concentrations of MGd. The fluorescence properties of MGd were then exploited using confocal microscopy to image exposed cells. For an in vivo validation study, we performed surface coil-based and intravascular coil-based high-resolution MRI of the iliac arteries and the abdominal aorta of three atherosclerotic Yucatan pigs. Subsequently, MGd enhancement of the target vessel walls was quantitatively evaluated and MR images were correlated with histology of the target vessels. Results: The in vitro study confirmed the intracellularization of MGd in both cell types and determined the optimum MGd dosage of 0.004 mmol/kg that produced the sufficiently high intracellular fluorescent intensity. The in vivo study showed a steady increase of MGd enhancement to approximately 25% at three hours postinjection of MGd. MRI showed areas of strong enhancement along the lumen boundary, which corresponded to fibrous tissue seen in histology. Conclusion: This study provides initial evidence that MGd may enhance MR vessel wall imaging for the characterization of plaque in deep-seated arteries. © 2007 Wiley-Liss, Inc