14- POINT DEMING PHILOSOPHY AND MANAGERS†: AN APPRAISAL

Managers in the present competitive world have to face tough competition to survive and sustain themselves in their area of operation. There are various Institutions offering MBA degree courses but the worth of these degree holders is a matter of suspicion. When they have to deal with practical situations, at times they might be troubled because what they actually did learn in their classes and from papers may not provide them with the right wisdom of timely usage of learned matter. Also, there are philosophies put forth by various Quality Gurus which these managers have seen in black and white when they were students but how many have made a practical concern and consideration over those is again a doubtful affair. This study thus try to identify the opinion of present generation managers about the applicability of 14- point philosophy laid down by the Father of Quality Management, Dr. W. Edward Deming. This is basically a research paper done after conducting an opinion survey among managers in general without looking into their area of operation

Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

<p>Abstract</p> <p>Background</p> <p>Osteoblast differentiation requires the coordinated stepwise expression of multiple genes. Histone deacetylase inhibitors (HDIs) accelerate the osteoblast differentiation process by blocking the activity of histone deacetylases (HDACs), which alter gene expression by modifying chromatin structure. We previously demonstrated that HDIs and HDAC3 shRNAs accelerate matrix mineralization and the expression of osteoblast maturation genes (e.g. alkaline phosphatase, osteocalcin). Identifying other genes that are differentially regulated by HDIs might identify new pathways that contribute to osteoblast differentiation.</p> <p>Results</p> <p>To identify other osteoblast genes that are altered early by HDIs, we incubated MC3T3-E1 preosteoblasts with HDIs (trichostatin A, MS-275, or valproic acid) for 18 hours in osteogenic conditions. The promotion of osteoblast differentiation by HDIs in this experiment was confirmed by osteogenic assays. Gene expression profiles relative to vehicle-treated cells were assessed by microarray analysis with Affymetrix GeneChip 430 2.0 arrays. The regulation of several genes by HDIs in MC3T3-E1 cells and primary osteoblasts was verified by quantitative real-time PCR. Nine genes were differentially regulated by at least two-fold after exposure to each of the three HDIs and six were verified by PCR in osteoblasts. Four of the verified genes (solute carrier family 9 isoform 3 regulator 1 (Slc9a3r1), sorbitol dehydrogenase 1, a kinase anchor protein, and glutathione S-transferase alpha 4) were induced. Two genes (proteasome subunit, beta type 10 and adaptor-related protein complex AP-4 sigma 1) were suppressed. We also identified eight growth factors and growth factor receptor genes that are significantly altered by each of the HDIs, including Frizzled related proteins 1 and 4, which modulate the Wnt signaling pathway.</p> <p>Conclusion</p> <p>This study identifies osteoblast genes that are regulated early by HDIs and indicates pathways that might promote osteoblast maturation following HDI exposure. One gene whose upregulation following HDI treatment is consistent with this notion is Slc9a3r1. Also known as NHERF1, Slc9a3r1 is required for optimal bone density. Similarly, the regulation of Wnt receptor genes indicates that this crucial pathway in osteoblast development is also affected by HDIs. These data support the hypothesis that HDIs regulate the expression of genes that promote osteoblast differentiation and maturation.</p

Marine Ecosystems Challenges and Opportunities (MECOS 2) Book of Abstracts

The 5th International Symposium on Cage Aquaculture in Asia (CAA5) is being organised by the Asian Fisheries Society and the ICAR-Central Marine Fisheries Research Institute (CMFRI), in association with the Asian Fisheries Society Indian Branch, from the 25th to 28th of November 2015 at Kochi, India. The event will cover an array of topics related to cage culture under the broad headings of Marine Production Systems, Inland Production Systems, Breeding and Seed Production, Nutrition and Feed, Health and Environment Management and Economics, Livelihood and Policies

Status of marine fisheries of Kerala

Kerala with a coastline of 590 km is a significant contributor to the total marine fish landings of the country. A picture of the marine fisheries sector in Kerala during the years 2005 and 2010 is presented below (Table 1). With a continental shelf of about 40,000 km2 marine fisheries plays a vital role in the livelihood of the people

English language acquisition through online mode of teaching during COVID-19 pandemic in India

Education and learning hitherto has undergone huge changes from the kind of teaching provided to Gen Y . One major differentiator is the rise of technology and the spread of internet. It has moved ahead&nbsp; from the ‘analog’ methods to the ‘digital’ methods. The unprecedented Covid-19 crisis which swept across the globes causing loss of human lives and forced people to stay indoors accelerated the process of seeking education through online modes. Thus, learning a language in such an advanced ecosystem is one of the most crucial components in terms of education. In developing countries such as India where English (used as a second language)&nbsp; is learnt not merely to communicate&nbsp; but as a tool for empowerment, the methods used to acquire the&nbsp; language needs to be&nbsp; assessed , helping the quality of language learning especially during the Covid-19 pandemic. The observations are based on various data collected using surveys etc during the lockdown imposed due to the COVID 19 pandemic in India.&nbsp

Role of human papillomavirus in the pathogenesis of oral lichen planus: A systematic review

Oral Lichen Planus (OLP) is a chronic inflammatory disease with a cell-mediated immunopathologic response. Although OLP has been studied extensively for decades, its exactaetiologyremains unclear. Autoimmunity, viruses like Hepatitis C Virus (HCV), Human Papillomavirus (HPV), and stress have all beenhypothesized in recent articles. HPVs are epitheliotropic viruses with an affinity for keratinocytes and are principally found in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa. This article aimed to review the frequency of HPV prevalence in OLP. A computer database search was performed through the use of PubMed from 1987 to 2021. The summary showed that the association of HPV and OLP varied significantly by geographic population. The correlation of HPV and erosive-atrophic oral lichen planus was comparable and well above that of HPV and non-EA-OLP. Among HPV genotypes, HPV 16 showed an extremely strong association with OLP, and HPV 18 showed a relatively strong one

Selective Synthesis of Benzaldehydes by Hypochlorite Oxidation of Benzyl Alcohols under Phase Transfer Catalysis

The selective synthesis of benazaldehyde and substituted benzaldehydes from corresponding benzyl al-cohols has been carried out by using hypochlorite as an oxidant in organic medium under phase trans-fer catalysis. The reaction is highly selective since no traces of benzoic acid or substituted benzoic acids have been detected and the yield is found to be more than 90%. The products obtained were precipi-tated as 2,4-dinitrophenylhydrazone and the recrystallised products were characterized by melting point and by spectrophotometric techniques like infra red and UV-Visible analysis. © 2015 BCREC UNDIP. All rights reserved.Received: 10th August 2014; Revised: 20th September 2014; Accepted: 21st September 2014How to Cite: Bijudas, K., Bashpa, P., Bibin, V. P., Nair, L., Priya, A. P., Aswathy, M., Krishnendu, C., Lisha, P. (2015). Selective Synthesis of Benzaldehydes by Hypochlorite Oxidation of Benzyl Alcohols under Phase Transfer Catalysis. Bulletin of Chemical Reaction Engineering &amp; Catalysis, 10 (1): 38-42. (doi:10.9767/bcrec.10.1.7189.38-42)Permalink/DOI: http://dx.doi.org/10.9767/bcrec.10.1.7189.38-42</p

Comparison of diagnostic ability of storage phosphor plate in detecting proximal caries with direct measurement by stereomicroscope: a pilot study

Radiography plays an important role in detection of interproximal caries. The aim of study is to compare diagnostic ability of photo stimulable phosphor (PSP) with direct measurement using stereomicroscope in detecting proximal caries. Hundred proximal surfaces of 50 extracted human posterior teeth were radiographed with dental X-ray unit. The image receptors used was storage phosphor plate Vista scan (size 2), (time of exposure 0.4 s). Radiographs were interpreted and caries lesions were classified on a 4-point scale suggested by Abesi et al. The teeth were sectioned with diamond disc and were examined under a stereomicroscope with 20x magnification. Diagnostic accuracy of digital image is similar to that observed with stereomicroscope. The PSP plate digital X ray system can effectively be employed for detecting proximal caries as compared to direct observation by stereomicroscope. Further study with more number of observer/evaluator and large sample size is recommended