Synthesis and studies of bissydnone sulfonamides based on 4,4’-diaminodiphenyl methane

3,3’-(4,4’-Diphenyl)bissydnonyl methane (5) was synthesized and subjected to chlorosulfonation followed by amination resulted in to formation of 3,3’-(methylenedi-1,4-phenylene)bis[4-{(4-substituted-amino)sulfonyl} sydnone (7a-j). The structure of the newly synthesized compounds was checked by spectral data and purity of the compounds was checked by elemental analysis as well as thin layer chromatography. Some compounds showed excellent activity against gram positive and gram negative bacterial strain

Synthesis and characterization of some sulfonamide based bis-sydnones and their <i style="">in vitro</i> antimicrobial activity

960-9644-Sulfonamide substituted novel sydnones have been synthesized. The synthetic strategy utilizes 4,4′-diamino­diphenyl­sulfone as starting material to obtain the 3,3′-(sulfonyldi-4,1-phenylene)bis(4-chlorosulfonyl)sydnone 6 through several steps viz. esterification, hydrolysis (saponification), nitrosation, cyclisa­tion and chlorosulfonation, which are then condensed with different secondary amines to get final compounds. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P. aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity

Sydnone sulfonamide derivatives as antibacterial, antifungal, antiproliferative and anti-HIV agents

Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone (5) was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental analysis. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells. © 2014 Springer Science+Business Media.status: publishe

Synthesis of novel biologically active methylene derivatives of sydnones

A series of mono and bis N-Mannich bases incorporating 3-(4-methylphenyl)- 4-(substituted-1/4-ylmethyl)sydnone scaffolds were synthesized and tested for their antibacterial, antifungal, anticancer, and antiviral activities. Most of the compounds showed moderate-to-significant antibacterial and antifungal activities. The compounds did not show selective activity against HIV. Some of the compounds have been evaluated for anticancer activity, but they were found as poorly active. The structures of the synthesized compounds were elucidated by IR and NMR spectroscopy. © 2013 Springer Science+Business Media New York.status: publishe