Authenticity, empathy, and the creative imagination

This article reviews the changing beliefs about artistic integrity and aesthetic value that feed into judgements of rock authenticity, taking issue with scholarship that reduces authenticity to acts of misguided judgement, myths, conceits, and fakery. It argues that there is no consensus about the meaning of authenticity in rock music, as understandings change according to the varied experiences, perceptions, circumstances, and vocabularies of participants. Authenticity in rock should not be approached cynically as if based on deception, gullibility, and ideological illusions, but for the insights it can provide into the circumstances that afford imaginative acts of creative connection and experiential empathy

Action selection and action awareness

Human actions are often classified as either internally generated, or externally specified in response to environmental cues. These two modes of action selection have distinct neural bases, but few studies investigated how the mode of action selection affects the subjective experience of action. We measured the experience of action using the subjective compression of the interval between actions and their effects, known as ‘temporal binding’. Participants performed either a left or a right key press, either in response to a specific cue, or as they freely chose. Moreover, the time of each keypress could either be explicitly cued to occur in one of two designated time intervals, or participants freely chose in which interval to act. Each action was followed by a specific tone. Participants judged the time of their actions or the time of the tone. Temporal binding was found for both internally generated and for stimulus-based actions. However, the amount of binding depended on whether or not both the choice and the timing of action were selected in the same way. Stronger binding was observed when both action choice and action timing were internally generated or externally specified, compared to conditions where the two parameters were selected by different routes. Our result suggests that temporal action–effect binding depends on how actions are selected. Binding is strongest when actions result from a single mode of selection

Risk Factors for Prognosis in Patients With Severely Decreased GFR

Introduction: Patients with chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR) < 30 ml/min per 1.73 m 2 (corresponding to CKD stage G4+) comprise a minority of the overall CKD population but have the highest risk for adverse outcomes. Many CKD G4+ patients are older with multiple comorbidities, which may distort associations between risk factors and clinical outcomes. Methods: We undertook a meta-analysis of risk factors for kidney failure treated with kidney replacement therapy (KRT), cardiovascular disease (CVD) events, and death in participants with CKD G4+ from 28 cohorts (n = 185,024) across the world who were part of the CKD Prognosis Consortium. Results: In the fully adjusted meta-analysis, risk factors associated with KRT were time-varying CVD, male sex, black race, diabetes, lower eGFR, and higher albuminuria and systolic blood pressure. Age was associated with a lower risk of KRT (adjusted hazard ratio: 0.74; 95% confidence interval: 0.69–0.80) overall, and also in the subgroup of individuals younger than 65 years. The risk factors for CVD events included male sex, history of CVD, diabetes, lower eGFR, higher albuminuria, and the onset of KRT. Systolic blood pressure showed a U-shaped association with CVD events. Risk factors for mortality were similar to those for CVD events but also included smoking. Most risk factors had qualitatively consistent associations across cohorts. Conclusion: Traditional CVD risk factors are of prognostic value in individuals with an eGFR < 30 ml/min per 1.73 m 2, although the risk estimates vary for kidney and CVD outcomes. These results should encourage interventional studies on correcting risk factors in this high-risk population

A General Purpose Transpiler for Fully Homomorphic Encryption

Fully homomorphic encryption (FHE) is an encryption scheme which enables computation on encrypted data without revealing the underlying data. While there have been many advances in the field of FHE, developing programs using FHE still requires expertise in cryptography. In this white paper, we present a fully homomorphic encryption transpiler that allows developers to convert high-level code (e.g., C++) that works on unencrypted data into high-level code that operates on encrypted data. Thus, our transpiler makes transformations possible on encrypted data. Our transpiler builds on Google's open-source XLS SDK (https://github.com/google/xls) and uses an off-the-shelf FHE library, TFHE (https://tfhe.github.io/tfhe/), to perform low-level FHE operations. The transpiler design is modular, which means the underlying FHE library as well as the high-level input and output languages can vary. This modularity will help accelerate FHE research by providing an easy way to compare arbitrary programs in different FHE schemes side-by-side. We hope this lays the groundwork for eventual easy adoption of FHE by software developers. As a proof-of-concept, we are releasing an experimental transpiler (https://github.com/google/fully-homomorphic-encryption/tree/main/transpiler) as open-source software