Enantioselective Henry reaction catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand and Cu(II) ion

WOS: 000292738500004Mild and efficient enantioselective Henry reactions of nitromethane with various aldehydes were catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 96%) and enantioselectivities (up to 92% ee).Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107T778]We are grateful to the Scientific and Technological Research Council of Turkey (TUBITAK) for its financial support (Project Number 107T778). Gamze Koz thanks TUBITAK for graduate scholarships

Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions

WOS: 000316587800010A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee).Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [210T147]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)We are grateful to The Scientific and Technological Research Council of Turkey (TUBITAK) for their financial support (210T147). G. K. thanks TUBITAK for a postdoctoral fellowship

Yeni Kiral Amid-Schiff Baz Türevlerinin Sentezi, Karakterizasyonu ve Antimikrobiyal Çalişmalari

In this study, new chiral Schiff bases (3-9) were synthesized via the reaction of chiral amide derivatives with various substituted aromatic aldehydes. the structures of the newly synthesized compounds were characterized by FTIR, 1 H-NMR, 13C-NMR and elemental analysis. All of these Schiff bases were tested in vitro against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria. Among the tested compounds compound 7 was found to show the most potent inhibitory action against test organisms.Bu çalışmada, kiral amid türevlerinin farklı sübstitüe aromatik aldehitler ile reaksiyonu yoluyla elde edilen yeni kiral Schiff bazları (3-9) sentezlendi. Yeni sentezlenen bileşiklerin yapıları FTIR, 1 H-NMR, 13C-NMR ve elementel analiz ile karakterize edildi. Bu Schiff bazlarının tümü Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans’a karşı antibakteriyel ve antifungal etkilerine karşı in vitro olarak test edildi. Tüm bileşikler, Gram pozitif ve Gram negatif bakterilere karşı orta ile iyi derecelerde antibakteriyel aktivite göstermiştir. Test edilen bileşikler arasında bileşik 7 test organizmalarına karşı en güçlü inhibe edici etkiyi göstermiştir

Synthesis, spectroscopic and structural characterization of cobalt(II) complex with uracil-containing 2,6-diformylpyridine ligand: Theoretical studies on the ligand and pentagonal-bipyramidal [Co(L)(H2O)(2)](2+) and [Zn(L)(H2O)(2)](2+) cations

WOS: 000275769700007The title complex, trans-diaqua{5,5'-[(E,E)-pyridine-2,6-diylbis(methylidynenitrilo)]bis-[pyrimidine-2,4 (1H,3H)-dionel)}cobalt(II) bis(hexafluorophosphate) dihydrate [Co(C15H11N7O4) (H2O)(2)]center dot 2(PF6)center dot 2(H2O), has been synthesized, and characterized by IR spectroscopy and single crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P2(1)/c with a = 10.7301(4) angstrom, b = 12.0537(3) angstrom, c = 21.6030(9) angstrom and beta = 109.392 (3)degrees. In the title complex, the Co2+ centre is seven-coordinated in a slightly distorted pentagonal-bipyramidal geometry, with the two water O atoms located in the apical positions, and the pyridine N atom, the two imine N atoms and two carbonyl O atoms of the uracil groups located in the equatorial plane. The positions of fluorine atoms in the hexafluorophosphate groups were disordered. The charge is balanced by two PF62- anions. In addition to the molecular geometry from X-ray experiment, theoretical studies have been carried out on the structures of the pentagonal-bipyramidal [Co(L)(H2O)(2)](2+) and [Zn(L)(H2O)(2)](2+) cations using the Hartree-Fock (HF) and density functional theory (DFT-B3LYP) methods in conjunction with effective core potential basis set (LANL2DZ) to clarify the solid state behaviour of these cations. Besides, frontier molecular orbitals (FMO) analysis and natural bond orbital (NBO) analysis of [Co(L)(H2O)(2)](2+) cation are presented here together with vibrational frequencies and gauge including atomic orbital (GIAO) H-1 and C-13 NMR chemical shift values of the pentadentate ligand calculated at HF and DFT (B3LYP) levels with 6-31G(d) basis set. (C) 2009 Elsevier B.V. All rights reserved.Research Centre of Ondokuz Mayis UniversityOndokuz Mayis University [F-461]This study was supported financially by the Research Centre of Ondokuz Mayis University (Project No.: F-461). Gamze Koz sincerely thanks TUBITAK (the Scientific and Technical Research Council of Turkey) for their bursary support

A highly novel dinickel complex: A hydrogen-bonded anti-skew carboxylate bridge and a 2D supramolecular structure

WOS: 000272570500010Reaction of the tridentate Schiff base ligands obtained from 2,4-dihydroxybenzaldehyde and either L-iso-leucine or L-tert-leucine with Ni(NO3)(2) in methanol/water solution in the presence of base afforded dinickel complexes. The crystal structure of the product derived from L-tert-leucine has been determined by X-ray crystallography. The octahedrally coordinated two Ni centers were found to be bridged by a single carboxylate group in an extremely unusual non-planar fashion. A 2D supramolecular structure, constructed by infinite hydrogen-bonded complex sheets parallel to the ab-plane of the unit cell, arises from intermolecular O-H center dot center dot center dot O hydrogen bonds. (C) 2009 Elsevier B.V. All rightsEge University Faculty of ScienceEge University; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107T778]The authors are grateful to Ege University Faculty of Science and to TUBITAK (Grant 107T778) for financial support of this work. The authors also acknowledge the Faculty of Arts and Sciences, Ondokuz Mayis University, Turkey, for the use of the Stoe IPDS-II diffractometer (purchased under Grant No. F.279 of the University Research Fund)

Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors

WOS: 000347956500012PubMed ID: 24666304A new series of chiral thiourea derivatives (5a-5c) and thiourea containing benzimidazole moieties (9b-9e) were synthesized from different amino acids (L-valine, L-isoleucine, L-methionine, L-phenylalanine, and D-phenylglycine). The compounds were characterized and tested against the two most studied members of the pH regulatory enzyme family, carbonic anhydrase (CA, EC 4.2.1.1). K-I values of the novel compounds were measured in the range of 3.4-73.6 mu M for hCA I isozyme and 8.7-1.44.2 mu M for hCA II isozyme, respectively. Phenol was also tested as standard in order to understand the structure activity relationship and the clinically used sulfonamide acetazolamide was tested for comparison reasons. All of the compounds exhibited competitive inhibition with 4-nitrophenylacetate as substrate

Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds

WOS: 000385270300044PubMed ID: 26634620A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. The investigated compounds showed inhibition constants in the range of 0.068-4003, 0.012-9.9 and 0.025-115 mm at the hCA I, hCA II and hCA IX enzymes, respectively. In order to investigate the binding mechanisms of these inhibitors, in silico studies were also applied. Molecular docking scores of the studied compounds are calculated using scoring algorithms, namely Glide/induced fit docking. The inhibitory potencies of the novel compounds were analyzed at the human isoforms hCA I, hCA II and hCA IX as targets and the K-I values were calculated.TUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z731]; Ege UniversityEge University [2011 Fen 050]; Ondokuz Mayis University Scientific Research Projects CouncilOndokuz Mayis University [2013/PYO.ZRT.1901.13.004]This study was financed by TUBITAK (The Scientific and Technological Research Council of Turkey) (Project no: 114Z731) for (MS), Ege University (Scientific Research Project 2011 Fen 050) for (NK and DA) and Ondokuz Mayis University Scientific Research Projects Council (Project no: 2013/PYO.ZRT.1901.13.004) for (DE). The authors report no conflicts of interest