A durabilidade da cultura bizantina e do simbolismo na Igreja Ortodoxa Oriental

The architectural style of the Eastern Orthodox Church temples in the twentieth century, in most countries that were under the Byzantine Empire, has had minor changes since the fall of the Empire. Orthodoxy is traditional for several reasons, one of which is that it is founded on Tradition. Between the Byzantine Rite and the elements- mostly architectural- there is no simple, clear, and direct correspondence. It is quite impossible to understand the rationale behind the liturgy, arts, and architecture, without a historical context of the Church.  Both liturgy and architecture have “an internal logic”, and their development is at different rates. The relationship between the Byzantine Rite and architecture goes through the Orthodox Church along with the meaning of the Byzantine Empire for the Church. The Byzantine architectural style of the churches is dynamic and had a lot of development during the time of the Empire. The use of this style by the Orthodox Church in the twentieth century is related to a complex matrix that starts with Tradition and goes through the prosperity that the Empire gave the Church in the first centuries.A linguagem e tipologia arquitetónicas da Igreja Ortodoxa Calcedoniana no século XX, na maioria dos países que faziam parte do Império Bizantino, sofreram apenas pequenas mudanças, desde a queda do Império. Várias razões concorrem para este fenómeno, nomeadamente o facto da ortodoxia possuir um forte sentido da Tradição que acentua a continuidade nas suas opções doutrinais (incluindo o Rito Bizantino) e arquitetónicas.A correspondência estilística, isto é, “a lógica interna” que liga os elementos – sobretudo arquitetónicos – não é imediatamente percetível sem recorrer a uma contextualização dos fatores históricos, especialmente os relacionados com o Império Bizantino. Por exemplo, a liturgia e a arquitetura estão intimamente ligadas, mas desenvolveram-se a ritmos diferentes. Ora, a adoção desse estilo pela Igreja Ortodoxa em pleno século XX pode ser apreciada como indexada a uma matriz complexa da Tradição com fortes influências dos momentos altos da cultura bizantina na vida primitiva desta Igreja

Developing National and International Guidelines.

Food allergy (FA) is considered an emerging public health problem. The development of evidence-based guidelines aims to help health care professionals in an accurate diagnosis and management of such diseases. It is proven that there are differences in the factors that determine FA in the different regions of the world. It is necessary to encourage standardization processes of guidelines development. Nevertheless, in the future it will be necessary to take into consideration not only a methodologically correct analysis of the evidence but also the socio-economic realities where the guidelines will be applied

APLIKASI PELAYANAN DAN PENYEDIA INFORMASI BERBASIS CHATBOT MENGGUNAKAN DEEP LEARNING DI UNIVERSITAS ISLAM MAJAPAHIT

Di Universitas Islam Majapahit, informasi bagi calon mahasiswa bisa didapatkan dengan cara datang ke kantor pelayanan informasi. Masalahnya, kantor pelayanan informasi memiliki keterbatasan jam dan hari kerja. Tentu menyulitkan bagi calon mahasiswa yang ingin mendapatkan informasi secara cepat. Aplikasi chatbot ini hadir sebagai salah satu solusi digunakan sebagai media layanan kepada siapa saja yang membutuhkan informasi secara cepat dan akurat. Siapapun bisa mengakses aplikasi kapanpun, dimanapun tanpa perlu khawatir terbatas pada jam dan hari kerja, dan mendapat respon yang diinginkan secara cepat. Menggunakan salah satu metode deep learning RNN (Recurrent Neural Network) yang merupakan jaringan saraf tiruan iteratif yang pemrosesannya dipanggil berulang kali untuk memproses input yang biasanya berupa data sekuensial.yang dan didukung oleh algoritma optimasi SGD (Stochastic Gradient Descent). Hasilnya model hidden layer 1 dengan 64 neuron dan hidden layer 2 32 neuron, trainingnya menghasilkan akurasi 93%, model 32x32 89% dan model 64x64 memiliki tingkat akurasi tertinggi dengan 94%

Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome

Kabuki syndrome (KS) is a complex multi-system developmental disorder associated with mutation of genes encoding histone-modifying proteins. In addition to craniofacial, intellectual, and cardiac defects, KS is also characterized by humoral immune deficiency and autoimmune disease, yet no detailed molecular characterization of the KS-associated immune phenotype has previously been reported

World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update – I – Plan and definitions

Since the World Allergy Organization (WAO) Diagnosis and Rationale against Cow's Milk Allergy (DRACMA) Guidelines were published 10 years ago, new evidence has accumulated about the diagnosis, therapy, and specific immunotherapy for cow's milk allergy (CMA). For this reason, WAO has felt the need to update the guidelines. We introduce here this update. The new DRACMA guidelines aim to comprehensively address the guidance on diagnosis and therapy of both IgE non-IgE-mediated forms of cow's milk allergy in children and adults. They will be divided into 18 chapters, each of which will be dedicated to an aspect. The focus will be on the meta-analyzes and recommendations that will be expressed for the 3 most relevant clinical aspects: (a) the diagnostic identification of the condition; (b) the choice of the replacement formula in case of CMA in infancy when the mother is not able to breastfeed, and (c) the use of specific immunotherapy for cow's milk protein allergy

Eosinophilic oesophagitis: clinical presentation and pathogenesis

Eosinophilic oesophagitis (EoE) is an inflammatory disorder of the oesophagus which has become increasingly recognised over recent years, although it remains underdiagnosed in many centres. It is characterised histologically by a significant eosinophilic infiltration of the oesophageal mucosa (>15 eosinophils per high powered field), and clinically with features of oesophageal dysfunction such a dysphagia, food impaction, and proton pump inhibitor (PPI) resistant dyspepsia. Fibrosis and oesophageal remodelling may occur and lead to oesophageal strictures. An allergic predisposition is common in the EoE population, which appears to be primarily food antigen driven in children and aeroallergen driven in adults. Evidence suggests that the pathogenesis of EoE is due to a dysregulated immunological response to an environmental allergen, resulting in a T helper type 2 (Th2) inflammatory disease and remodelling of the oesophagus in genetically susceptible individuals. Allergen elimination and anti-inflammatory therapy with corticosteroids are currently the mainstay of treatment; however, an increasing number of studies are now focused on targeting different stages in the disease pathogenesis. A greater understanding of the underlying mechanisms resulting in EoE will allow us to improve the therapeutic options available

Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges

Background: Food allergy prevalence has continued to rise over the past decade. While studies have reported threshold doses for multiple foods, large-scale multi-food allergen studies are lacking. Our goal was to identify threshold dose distributions and predictors of severe reactions during blinded oral food challenges (OFCs) in multi-food allergic patients.Methods: A retrospective chart review was performed on all Stanford-initiated clinical protocols involving standardized screening OFCs to any of 11 food allergens at 7 sites. Interval-censoring survival analysis was used to calculate eliciting dose (ED) curves for each food. Changes in severity and ED were also analyzed among participants who had repeated challenges to the same food.Results: Of 428 participants, 410 (96%) had at least one positive challenge (1445 standardized OFCs with 1054 total positive challenges). Participants undergoing peanut challenges had the highest ED50 (29.9 mg), while those challenged with egg or pistachio had the lowest (7.07 or 1.7 mg, respectively). The most common adverse event was skin related (54%), followed by gastrointestinal (GI) events (33%). A history of asthma was associated with a significantly higher risk of a severe reaction (hazard ratio [HR]: 2.37, 95% confidence interval [CI]: 1.36, 4.13). Higher values of allergen-specific IgE (sIgE) and sIgE to total IgE ratio (sIgEr) were also associated with higher risk of a severe reaction (1.49 [1.19, 1.85] and 1.84 [1.30, 2.59], respectively). Participants undergoing cashew, peanut, pecan, sesame, and walnut challenges had more severe reactions as ED increased. In participants who underwent repeat challenges, the ED did not change (p = 0.66), but reactions were more severe (p = 0.02).Conclusions: Participants with a history of asthma, high sIgEr, and/or high values of sIgE were found to be at higher risk for severe reactions during food challenges. These findings may help to optimize food challenge dosing schemes in multi-food allergic, atopic patients, specifically at lower doses where the majority of reactions occur.Trials Registration Number: ClinicalTrials. gov number NCT03539692; https://clinicaltrials.gov/ct2/show/NCT03539692