The Speedup Theorem in a Primitive Recursive Framework

Blum’s speedup theorem is a major theorem in computational com-plexity, showing the existence of computable functions for which no optimal program can exist: for any speedup function r there ex-ists a function fr such that for any program computing fr we can find an alternative program computing it with the desired speedup r. The main corollary is that algorithmic problems do not have, in general, a inherent complexity. Traditional proofs of the speedup theorem make an essential use of Kleene’s fix point theorem to close a suitable diagonal argument. As a consequence, very little is known about its validity in subrecursive settings, where there is no universal machine, and no fixpoints. In this article we discuss an alternative, formal proof of the speedup theorem that allows us to spare the invocation of the fix point theorem and sheds more light on the actual complexity of the function fr

Quantitative Models and Implicit Complexity

We give new proofs of soundness (all representable functions on base types lies in certain complexity classes) for Elementary Affine Logic, LFPL (a language for polytime computation close to realistic functional programming introduced by one of us), Light Affine Logic and Soft Affine Logic. The proofs are based on a common semantical framework which is merely instantiated in four different ways. The framework consists of an innovative modification of realizability which allows us to use resource-bounded computations as realisers as opposed to including all Turing computable functions as is usually the case in realizability constructions. For example, all realisers in the model for LFPL are polynomially bounded computations whence soundness holds by construction of the model. The work then lies in being able to interpret all the required constructs in the model. While being the first entirely semantical proof of polytime soundness for light logi cs, our proof also provides a notable simplification of the original already semantical proof of polytime soundness for LFPL. A new result made possible by the semantic framework is the addition of polymorphism and a modality to LFPL thus allowing for an internal definition of inductive datatypes.Comment: 29 page

Verification of PCP-Related Computational Reductions in Coq

We formally verify several computational reductions concerning the Post correspondence problem (PCP) using the proof assistant Coq. Our verifications include a reduction of a string rewriting problem generalising the halting problem for Turing machines to PCP, and reductions of PCP to the intersection problem and the palindrome problem for context-free grammars. Interestingly, rigorous correctness proofs for some of the reductions are missing in the literature

A Survey on Retrieval of Mathematical Knowledge

We present a short survey of the literature on indexing and retrieval of mathematical knowledge, with pointers to 72 papers and tentative taxonomies of both retrieval problems and recurring techniques.Comment: CICM 2015, 20 page

Sharing HOL4 and HOL Light proof knowledge

New proof assistant developments often involve concepts similar to already formalized ones. When proving their properties, a human can often take inspiration from the existing formalized proofs available in other provers or libraries. In this paper we propose and evaluate a number of methods, which strengthen proof automation by learning from proof libraries of different provers. Certain conjectures can be proved directly from the dependencies induced by similar proofs in the other library. Even if exact correspondences are not found, learning-reasoning systems can make use of the association between proved theorems and their characteristics to predict the relevant premises. Such external help can be further combined with internal advice. We evaluate the proposed knowledge-sharing methods by reproving the HOL Light and HOL4 standard libraries. The learning-reasoning system HOL(y)Hammer, whose single best strategy could automatically find proofs for 30% of the HOL Light problems, can prove 40% with the knowledge from HOL4

Typing a Core Binary Field Arithmetic in a Light Logic

We design a library for binary field arithmetic and we supply a core API which is completely developed in DLAL, extended with a fix point formula. Since DLAL is a restriction of linear logic where only functional programs with polynomial evaluation cost can be typed, we obtain the core of a functional programming setting for binary field arithmetic with built-in polynomial complexity

Graphical Reasoning in Compact Closed Categories for Quantum Computation

Compact closed categories provide a foundational formalism for a variety of important domains, including quantum computation. These categories have a natural visualisation as a form of graphs. We present a formalism for equational reasoning about such graphs and develop this into a generic proof system with a fixed logical kernel for equational reasoning about compact closed categories. Automating this reasoning process is motivated by the slow and error prone nature of manual graph manipulation. A salient feature of our system is that it provides a formal and declarative account of derived results that can include `ellipses'-style notation. We illustrate the framework by instantiating it for a graphical language of quantum computation and show how this can be used to perform symbolic computation.Comment: 21 pages, 9 figures. This is the journal version of the paper published at AIS

A Foundational View on Integration Problems

The integration of reasoning and computation services across system and language boundaries is a challenging problem of computer science. In this paper, we use integration for the scenario where we have two systems that we integrate by moving problems and solutions between them. While this scenario is often approached from an engineering perspective, we take a foundational view. Based on the generic declarative language MMT, we develop a theoretical framework for system integration using theories and partial theory morphisms. Because MMT permits representations of the meta-logical foundations themselves, this includes integration across logics. We discuss safe and unsafe integration schemes and devise a general form of safe integration

Isabelle/PIDE as Platform for Educational Tools

The Isabelle/PIDE platform addresses the question whether proof assistants of the LCF family are suitable as technological basis for educational tools. The traditionally strong logical foundations of systems like HOL, Coq, or Isabelle have so far been counter-balanced by somewhat inaccessible interaction via the TTY (or minor variations like the well-known Proof General / Emacs interface). Thus the fundamental question of math education tools with fully-formal background theories has often been answered negatively due to accidental weaknesses of existing proof engines. The idea of "PIDE" (which means "Prover IDE") is to integrate existing provers like Isabelle into a larger environment, that facilitates access by end-users and other tools. We use Scala to expose the proof engine in ML to the JVM world, where many user-interfaces, editor frameworks, and educational tools already exist. This shall ultimately lead to combined mathematical assistants, where the logical engine is in the background, without obstructing the view on applications of formal methods, formalized mathematics, and math education in particular.Comment: In Proceedings THedu'11, arXiv:1202.453

Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer

Prostate cancer (PCa) is a leading cause of death in the male population commonly treated with androgen deprivation therapy that often relapses as androgen-independent and aggressive castration-resistant prostate cancer (CRPC). Ferroptosis is a recently described form of cell death that requires abundant cytosolic labile iron to promote membrane lipid peroxidation and which can be induced by agents that inhibit the glutathione peroxidase-4 activity such as RSL3. Exploiting in vitro and in vivo human and murine PCa models and the multistage transgenic TRAMP model of PCa we show that RSL3 induces ferroptosis in PCa cells and demonstrate for the first time that iron supplementation significantly increases the effect of RSL3 triggering lipid peroxidation, enhanced intracellular stress and leading to cancer cell death. Moreover, the combination with the second generation anti-androgen drug enzalutamide potentiates the effect of the RSL3 + iron combination leading to superior inhibition of PCa and preventing the onset of CRPC in the TRAMP mouse model. These data open new perspectives in the use of pro-ferroptotic approaches alone or in combination with enzalutamide for the treatment of PCa