A convenient synthesis of 1,2-diphenyl-9H-[l]benzopyrano [3,2-b] pyrrol-9-ones utilizing hypervalent iodine reagent

536-53

Sodium borohydride reduction of E-3- benzylideneflavanones : Stereoselective formation of 3(S*)-benzyl-4(S*)-hydroxy-2(S*)-flavans

1164-116

A Rapid, Efficient and Green Method for Synthesis of 3,3'-Arylmethylene-bis-4-hydroxycoumarins without Use of any Solvent, Catalyst or Solid Surface

Abstract: A rapid, efficient and green methodology has been developed for the synthesis of 3,3'-arylmethylene-bis-4-hydroxycoumarins by microwave assisted condensation of aromatic aldehydes and 4-hydroxycoumarin without use of any solvent, catalyst or solid surface

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Novel conversion of some <i style="mso-bidi-font-style:normal">E</i>-3-benzylideneflavanones to 3-benzoylchromones <span style="font-size:12.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-IN;mso-fareast-language: EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">under a Schmidt rearrangement condition</span>

889-892<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">On treatment with NaN3/TFA, some E-3-benzylideneflavanones yield 3-benwylchromones with the loss of 2-aryl group as the corresponding aniline, a plausible mechanistic path for which has been delineated. An acid-catalysed skeletal rearrangement of some E-3-benzylideneflavanones also takes place.</span

A simple conversion of <i style="">E</i>-3-benzylidene­flavanones to 3-benzoylflavones by chromic acid oxidation

1947-1949Oxidation of E-3-benzylideneflavanones with CrO3/AcOH yields 3-benzoylflavones in moderate yield

Analysis and synthesis of mechanical error in path-generating linkages using a stochastic approach

A stochastic model of the four-bar, path-generating linkage has been made. Tolerances and clearances have been assumed to be random variables. The mechanical error in the path of a coupler point is analyzed for the three-sigma band of confidence level. For a specified path, the mechanical error depends on the selection of either the original or its cognate mechanism. A synthesis procedure to allocate tolerances and clearances on different members and joints of a linkage so as to restrict the output error in the path of the coupler point within specified limits is developed. The synthesis procedure helps the designer in finding out how much the tolerance or clerance on particular variable is critical in terms of affecting the output error in the path of a coupler point. Results of an illustrative example are given in the paper

<span style="font-size:21.5pt;mso-bidi-font-size:14.5pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA; mso-bidi-font-weight:bold">Zinc-induced novel reductive cyclodimerisation of some <img src='/image/spc_char/alpha.gif' border=0>, β-unsaturated ketones

400-402<span style="font-size:15.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">Some , β<span style="font-size:15.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"=""> -unsaturated ketones are found to undergo zinc-induced novel reductive cyclodimerisation yiel-ding substituted  cyclo-pentanols as major products.</span

A convenient synthesis of 2-benzoyl-1, 5-diphenylpyrroles, a class of potentially biologically active compounds

2032-2034Reaction of ω-cinnamylideneacetophenones with nitrosobenzene in methylene chloride affords 2-benzoyl-1,5-diphenylpyrroles in very good yield through a [4+2]-cycloaddition of the reactants followed by a rearrangement of the cycloaddition product

Facile formation of bis(3-indolyl)methylarenes by iodine-catalyzed reaction of indole with ⍺,⍺'-bis(arylmethylene)ketones and ⍺-substituted arylmethyleneketones in dry ethanol

2056-2059Bis(3-indolyl)methylarenes are obtained in good yield by reaction of indole with ⍺,⍺-bis(arylmethylene)ketones and ⍺-substituted arylmethyleneketones in dry ethanol using catalytic amount of molecular iodine at room temperature. A plausible mechanism for formation of these products has been suggested