HELiPOD - revolution and evolution of a helicopter borne measurements system for multidisciplinary research in demanding environments

The helicopter-borne measurement system HELiPOD is a platform for atmospheric and other environmental measurements to investigate local and regional phenomena. It can be operated in remote areas, as from a research vessel with a helicopter, without the need for a runway. This article presents the current design concept, technical details and sensor package of HELiPOD, which was completely renewed for the deployment during the MOSAiC (Multidisciplinary drifting Observatory for the Study of Arctic Climate) expedition across the North Polar Ocean in 2019/2020. It was updated for the deployment in the methane campaigns METHANE-To-Go-Poland to study methane emissions from coal mines in South Poland, and METHANE-To-Go-Nordstream, a follow-up campaign to study methane emissions from the Baltic Sea after the NordStream pipeline leaks in 2022. The HELiPOD has dimensions of 5.2 m x 2.1 m x 1.2 m and a weight of around 325 kg. It provides the possibility for flight patterns on a horizontal scale of typically 100 m to 100 km and at altitudes from 10 m up to 3 km. HELiPOD employs distributed data acquisition and central data synchronization, equipped with sensors relevant to five fields of research: atmospheric dynamics, trace gases, aerosols, radiation and surface properties. The focus of the article is the technical realization, in particular the data acquisition system for about 60 sensors, as well as concepts for energy supply and thermalmanagement. It describes the complementary use of different measurement principles and redundant sensors for improved data quality. Operational procedures are also discussed

The Orchestration Stack: The Impossible Task of Designing Software for Unknown Future Post-CMOS Hardware

Future systems based on post-CMOS technologies will be wildly heterogeneous, with properties largely unknown today. This paper presents our design of a new hardware/software stack to address the challenge of preparing software development for such systems. It combines well-understood technologies from different areas, e.g., network-on-chips, capability operating systems, flexible programming models and model checking. We describe our approach and provide details on key technologies

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Akupunktur bei Operationen am offenen Herzen und Schädel

This article reviews the use of general anaesthesia with assisted acupuncture, which is becoming of increasing interest not only in Asia, but also in the western world. The focus is on two recent meta-analyses of 17 randomized controlled trials (RCTs) comparing general anaesthesia with assisted acupuncture to standard general anaesthesia in cardiac and neurosurgery. Significant reduction of sedative and vasoactive drug use, ventilation time, length of stay in the intensive care unit, and tissue damage markers was discovered. Although atotal of almost 1200 patients were included in these meta-analyses, additional RCTs are necessary to further support these positive findings

Moxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS

Abstract Background We tested the hypothesis that moxifloxacin monotherapy is equally effective and safe as a betalactam antibiotic based combination therapy in patients with acute respiratory distress syndrome (ARDS) evoked by severe community acquired pneumonia (CAP). Methods In a retrospective chart review study of 229 patients with adult respiratory distress syndrome (ARDS) admitted to our intensive care unit between 2001 and 2011, 169 well-characterized patients were identified to suffer from severe CAP. Patients were treated with moxifloxacin alone, moxifloxacin in combination with ß-lactam antibiotics, or with another antibiotic regimen based on ß-lactam antibiotics, at the discretion of the admitting attending physician. The primary endpoint was 30-day survival. To assess potential drug-induced liver injury, we also analyzed biomarkers of liver cell integrity. Results 30-day survival (69% overall) did not differ (p = 0.89) between moxifloxacin monotherapy (n = 42), moxifloxacin combination therapy (n = 44), and other antibiotic treatments (n = 83). We found significantly greater maximum activity of aspartate transaminase (p = 0.048), alanine aminotransferase (p = 0.003), and direct bilirubin concentration (p = 0.01) in the moxifloxacin treated groups over the first 10–20 days. However, these in-between group differences faded over time, and no differences remained during the last 10 days of observation. Conclusions In CAP evoked ARDS, moxifloxacin monotherapy and moxifloxacin combination therapy was not different to a betalactam based antibiotic regimen with respect to 30-day mortality, and temporarily increased markers of liver cell integrity had no apparent clinical impact. Thus, in contrast to the current S3 guidelines, moxifloxacin may also be safe and effective even in patients with severe CAP evoked ARDS while providing coverage of an extended spectrum of severe CAP evoking bacteria. However, further prospective studies are needed for definite recommendations

R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis

Abstract Background Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor) improves pulmonary function in a sheep model of septic shock caused by Pseudomonas aeruginosa and smoke inhalation. Methods Eleven female sheep were prepared surgically and randomly assigned to a treatment group (n = 5) or a control group (n = 6) after inhalation of cooled cotton smoke and airway instillation of live P. aeruginosa (2.5 × 1011 CFU) by bronchoscope under deep anesthesia and analgesia. The treatment group received an intravenous infusion of a total of 80 mg/kg of R-100 diluted in 500 mL of 5% dextrose. The control group was given 500 mL of 5% dextrose. All animals received intravenous lactated Ringer’s solution to maintain a hematocrit level at baseline ± 3%. Blood gas and hemodynamics were measured at baseline and then analyzed every 3 h during the 24-h study period. Results are expressed as mean ± SEM. Results The treated animals showed significant improvement in their pulmonary gas exchange (PaO2/FiO2 ratio at 24 h: 246 ± 29 vs. 90 ± 40 mmHg control, P < 0.05). Pulmonary arterial pressures were reduced in the treated group (24 h: 26 ± 1 vs. 30 ± 2 cm mmHg control, P < 0.05). The treated animals also had an improved total fluid balance after 24 h (190 ± 45/24 h mL vs. 595 ± 234/24 h mL control, P < 0.05). Conclusions Treatment with R-100 improves pulmonary gas exchange and blood oxygenation, and prevents a fluid imbalance in sheep subjected to smoke inhalation and P. aeruginosa