{2-[(3-Bromo­benzyl­idene)amino]-5-chloro­phen­yl}(phen­yl)methanone

In the title compound, C20H13BrClNO, the azomethine double bond [C=N = 1.246 (4) Å] adopts an E conformation. The bromo- and chlorophenyl rings are inclined to one another by 13.70 (11)°, and form dihedral angles of 76.68 (10) and 74.24 (7)°, respectively, with the phenyl ring. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds to form double stranded chains propagating along the b-axis direction

17-(Pyrimidin-2-yl)-8,16-dioxa-17-aza­tetra­cyclo­[7.7.1.02,7.010,15]hepta­deca-2,4,6,10,12,14-hexa­ene

In the title compound, C18H13N3O2, the benzene rings form a dihedral angle of 78.49 (9)°. The dihedral angles between the benzene rings and the pyrimidine ring are 76.53 (10) and 27.73 (11)°. The two cis-fused six-membered heterocyclic rings adopt half-chair confirmations. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains parallel to the b axis

[4,4′-(Ethane-1,2-diyldinitrilo)­bis­(pent-2-en-2-olato)]copper(II) 0.25-hydrate

In the title compound, [Cu(C12H18N2O2)]·0.25H2O, the coordination of the O,N,N′,O′-tetra­dentate ligand results in a cis-CuN2O2 square-planar geometry for the metal ion and the presence of two six-membered and one five-membered chelate rings. The complete complex mol­ecule is close to planar (r.m.s. deviation = 0.047 Å). The uncoordinated water mol­ecule (O-atom site symmetry 2) was modelled as half occupied. In the crystal, C—H⋯Ow and Ow—H⋯O (w = water) hydrogen bonds link the components into layers parallel to ab plane

Hedonic Analysis of Arthritis Drugs

We examine the relationship between quality'' and market outcomes for a group of drugs used to treat rheumatoid arthritis. Though this is a widespread and debilitating disease with very substantial impacts on the health of patients and on the economy, currently available drugs have limited efficacy and serious side effects. Clinical research conducted since these products were approved has resulted in substantial revisions to the body of scientific information available to physicians. The relative quality' of these drugs (as captured by efficacy and toxicity measurements reported in peer-reviewed clinical trials) has changed markedly over the past 15 years. Yet in our analysis of US wholesale prices we find that relative prices appear to be only weakly related to quality. We do however find a relationship between changes in reported efficacy and toxicity and the evolution of quantity shares in this market.

Unanticipated hospital admission after ambulatory surgery

The unplanned admission rate is considered to be an important measure of the quality of ambulatory surgical units. The objective of our study was to evaluate the unanticipated hospital admission rate from the Surgical Day Care (SDC) unit of our university affiliated teaching hospital and to analyze the reasons for admission. A review of all unanticipated admissions over a one-year period was done. The admission rate was calculated and the reasons for admission were analysed. The overall admission rate was 4.93%. Most of the admissions were ordered by the surgeons (97%). The main reasons for admission were patient observation indicated for various reasons (72%) and patient request (18%). Eighty percent of the admitted patients had received general anaesthesia. Admissions were also related to the male gender (69%), age over 65 years (27%) and surgeries ending in the afternoon (69%). On analyzing the reasons for admission, a large number of admissions were found to be due to preventable causes. We conclude that proper selection of patients, careful scheduling of lists and education of patients and clinical professionals can help to avoid many unanticipated admissions after day care surgical procedures

Using a discrete choice experiment to estimate societal health state utility values

In this study we explore a novel application of the Discrete Choice Experiment (DCE) that resembles the Time Trade Off (TTO) task to estimate values on the health utility scale for the EQ-5D. The DCE is tested in a survey alongside the TTO in respondents largely representative of the Canadian general population. The study finds that the DCE is able to derive logical and consistent values for health states valued on the full health – dead scale. The DCE overcame some issues identified in the version of TTO currently used to value EQ-5D, notably whether to exclude respondents who fail to understand the task and incorporating values considered worse than dead without transformation. This has important implications for providing values that represent the preferences of all respondents

{5-Chloro-2-[(2-hy­droxy­benzyl­idene)amino]­phen­yl}(phen­yl)methanone

The title Schiff base compound, C20H14ClNO2, adopts an E configuration about the azomethine bond. The phenol and chloro­benzene rings form dihedral angles of 84.71 (9) and 80.70 (8)°, respectively, with the phenyl ring and are twisted by 15.32 (8)° with respect to one another. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯N hydrogen bond, which forms an S(6) ring motif. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, forming columns parallel to the a axis

Biological evaluation of potent antioxidant, lipoxygenase inhibitor and antibacterial: A comparative study

AbstractThree biologically active new Schiff bases, 2-[(3-hydroxybenzylidene)amino]phenol 5, 2-[(4-hydroxybenzylidene)amino]phenol 6 and 4-[(2-hydroxyphenylimino)methyl]benzene-1,3-diol 7, were synthesized by the reaction of 2-aminophenol 1 with three different hydroxyl-benzaldehydes 2–4. They were characterized by spectroscopic analysis (IR, 1H NMR, EI-MS) along with elemental analyses. The products were biological screened out for antioxidant, lipoxygenase inhibition, antibacterial and urease inhibition activities. The compounds 5 and 6 showed potent while 7 showed moderate antioxidant activity. Compound 6 showed potent whereas 5 and 7 showed significant lipoxygenase inhibition activity. All the target compounds showed excellent activities against Staphylococcus intermedius, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi bacteria. All the compounds showed non-significant activity against urease enzyme