Probing the electron EDM with cold molecules

We present progress towards a new measurement of the electron electric dipole moment using a cold supersonic beam of YbF molecules. Data are currently being taken with a sensitivity of $10^{-27}\textrm{e.cm}/\sqrt{\textrm{day}}$. We therefore expect to make an improvement over the Tl experiment of Commins' group, which currently gives the most precise result. We discuss the systematic and statistical errors and comment on the future prospect of making a measurement at the level of $10^{-29}\textrm{e.cm}/\sqrt{\textrm{day}}$.Comment: 8 pages, 6 figures, proceedings of ICAP 200

Acoustic-roughness receptivity in subsonic boundary-layer flows over aerofoils

The generation of a viscous–inviscid instability through scattering of an acoustic wave by localised and distributed roughness on the upper surface of a NACA 0012 aerofoil is studied with a time-harmonic compressible adjoint linearised Navier–Stokes approach. This extends previous work by the authors dedicated to flat plate geometries. The key advancement lies in the modelling of the inviscid acoustic field external to the aerofoil boundary layer, requiring a numerical solution of the convected Helmholtz equation in a non-uniform inviscid field to determine the unsteady pressure field on the curved aerofoil surface. This externally imposed acoustic pressure field subsequently drives the acoustic boundary layer, which fundamentally determines the amplitudes of acoustic-roughness receptivity. A study of receptivity in the presence of Gaussian-shaped roughness and sinusoidally distributed roughness at Mach number M∞ = 0.4 and Strouhal numbers S ≈ {46, 69, 115} shows the effects of various parameters, most notably angle of attack, angle of incidence of the externally imposed plane acoustic wave and geometry of surface roughness; the latter is varied from viewpoint of its placement on the aerofoil surface and its wavelength. The parametric study suggests that non-parallel effects are quite substantial and that considerable differences arise when using parallel flow theory to estimate the optimal width of Gaussian-shaped roughness elements to provoke the greatest response. Furthermore, receptivity amplitudes for distributed roughness are observed to be generally higher for lower angles of attack, i.e. for less adverse pressure gradients. It is also shown that the boundary layer is more receptive to upstream-travelling acoustic waves

Toward a simulation approach for alkene ring-closing metathesis : scope and limitations of a model for RCM

A published model for revealing solvent effects on the ring-closing metathesis (RCM) reaction of di-Et diallylmalonate 7 has been evaluated over a wider range of conditions, to assess its suitability for new applications. Unfortunately, the model is too flexible and the published rate consts. do not agree with exptl. studies in the literature. However, by fixing the values of important rate consts. and restricting the concn. ranges studied, useful conclusions can be drawn about the relative rates of RCM of different substrates, precatalyst concn. can be simulated accurately and the effect of precatalyst loading can be anticipated. Progress has also been made toward applying the model to precatalyst evaluation, but further modifications to the model are necessary to achieve much broader aims

Rapid Cooling of the Neutron Star in Cassiopeia A Triggered by Neutron Superfluidity in Dense Matter

We propose that the observed cooling of the neutron star in Cassiopeia A is due to enhanced neutrino emission from the recent onset of the breaking and formation of neutron Cooper pairs in the 3P2 channel. We find that the critical temperature for this superfluid transition is ~0.5x10^9 K. The observed rapidity of the cooling implies that protons were already in a superconducting state with a larger critical temperature. Our prediction that this cooling will continue for several decades at the present rate can be tested by continuous monitoring of this neutron star.Comment: Revised version, to be published in Phys. Rev. Let

Upper Limits On Periodic, Pulsed Radio Emission from the X-Ray Point Source in Cassiopeia A

The Chandra X-ray Observatory recently discovered an X-ray point source near the center of Cassiopeia A, the youngest known Galactic supernova remnant. We have conducted a sensitive search for radio pulsations from this source with the Very Large Array, taking advantage of the high angular resolution of the array to resolve out the emission from the remnant itself. No convincing signatures of a dispersed, periodic source or of isolated dispersed pulses were found, whether for an isolated or a binary source. We derive upper limits of 30 and 1.3 mJy at 327 and 1435 MHz for the phase-averaged pulsed flux density from this source. The corresponding luminosity limits are lower than those for any pulsar with age less than 10^4 years. The sensitivities of our search to single pulses were 25 and 1.0 Jy at 327 and 1435 MHz. For comparison, the Crab pulsar emits roughly 80 pulses per minute with flux densities greater than 100 Jy at 327 MHz and 8 pulses per minute with flux densities greater than 50 Jy at 1435 MHz. These limits are consistent with the suggestion that the X-ray point source in Cas A adds to the growing number of neutron stars which are not radio pulsars.Comment: accepted by ApJ Letter

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin appendages called cylindromas. Familial cylindromatosis is caused by mutations in a gene encoding the CYLD protein of previously unknown function1. Here we show that CYLD is a deubiquitinating enzyme that negatively regulates activation of the transcription factor NF-κB by specific tumour-necrosis factor receptors (TNFRs). Loss of the deubiquitinating activity of CYLD correlates with tumorigenesis. CYLD inhibits activation of NF-κB by the TNFR family members CD40, XEDAR and EDAR in a manner that depends on the deubiquitinating activity of CYLD. Downregulation of CYLD by RNA-mediated interference augments both basal and CD40-mediated activation of NF-κB. The inhibition of NF-κB activation by CYLD is mediated, at least in part, by the deubiquitination and inactivation of TNFR-associated factor 2 (TRAF2) and, to a lesser extent, TRAF6. These results indicate that CYLD is a negative regulator of the cytokine-mediated activation of NF-κB that is required for appropriate cellular homeostasis of skin appendages

Coherently Dedispersed Polarimetry of Millisecond Pulsars

We present a large sample of high-precision, coherently-dedispersed polarization profiles of millisecond pulsars (MSPs) at frequencies between 410 and 1414 MHz. These data include the first polarimetric observations of several of the pulsars, and the first low-frequency polarization profiles for others. Our observations support previous suggestions that the pulse shapes and polarimetry of MSPs are more complex than those of their slower relatives. An immediate conclusion is that polarimetry-based classification schemes proposed for young pulsars are of only limited use when applied to millisecond pulsars.Comment: 28 pages, 10 figures. Text matches version that appeared in ApJS. Full paper with high-resolution figures available at ftp://ftp.jb.man.ac.uk/pub/psr/papers/msppolpton.ps.g

C1 inhibitor deficiency: 2014 United Kingdom consensus document

C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK. To develop the consensus, we assembled a multi-disciplinary steering group of clinicians, nurses and a patient representative. This steering group first met in 2012, developing a total of 48 recommendations across 11 themes. The statements were distributed to relevant clinicians and a representative group of patients to be scored for agreement on a Likert scale. All 48 statements achieved a high degree of consensus, indicating strong alignment of opinion. The recommendations have evolved significantly since the 2005 document, with particularly notable developments including an improved evidence base to guide dosing and indications for acute treatment, greater emphasis on home therapy for acute attacks and a strong focus on service organisation. This article is protected by copyright. All rights reserved

Chandra Detection of the Forward and Reverse Shocks in Cassiopeia-A

We report the localization of the forward and reversed shock fronts in the young supernova remnant Cas-A using X-ray data obtained with the Chandra Observatory. High resolution X-ray maps resolve a previously unseen X-ray feature encompassing the extremity of the remnant. This feature consists of thin, tangential wisps of emission bordering the outer edge of the thermal X-ray and radio remnant, forming a circular rim, approx. 2.7 in radius. Radio images show a sharp rise in brightness at this X-ray rim, along with a large jump in the synchrotron polarization angle. These characteristics suggest that these wisps are the previously unresolved signature of the forward, or outer, shock. Similarly, we identify the sharp rise in emissivity of the bright shell for both the radio and X-ray line emission associated with the reverse shock. The derived ratio of the averaged forward and reverse shock radii of approx. 3:2 constrains the remnant to have swept up roughly the same amount of mass as was ejected; this suggests that Cas-A is just entering the Sedov phase. Comparison of the X-ray spectra from the two shock regions shows that the equivalent widths of prominent emission lines are significantly lower exterior to the bright shell, as expected if they are respectively identified with the shocked circumstellar material and shocked ejecta. Furthermore, the spectrum of the outer rim itself is dominated by power-law emission, likely the counterpart of the non-thermal component previously seen at energies above 10 keV.Comment: 7 pages with 5 figures, LaTex, emulateapj.sty. To appear in the Astrophysical Journal Letter

Waterborne Elizabethkingia meningoseptica in adult critical care

Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen