Gossip Codes for Fingerprinting: Construction, Erasure Analysis and Pirate Tracing

This work presents two new construction techniques for q-ary Gossip codes from tdesigns and Traceability schemes. These Gossip codes achieve the shortest code length specified in terms of code parameters and can withstand erasures in digital fingerprinting applications. This work presents the construction of embedded Gossip codes for extending an existing Gossip code into a bigger code. It discusses the construction of concatenated codes and realisation of erasure model through concatenated codes.Comment: 28 page

Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART

Background & Objective. IRIS is an important complication that occurs during management of HIV-TB coinfection and it poses difficulty in diagnosis. Previous studies have reported variable incidence of IRIS. The present study was undertaken to describe the pattern of TB-associated IRIS using recently proposed consensus case-definitions for TB-IRIS for its use in resource-limited settings. Methods. A prospective analysis of ART-naïve adults started on HAART from November, 2008 to May, 2010 was done in a tertiary care hospital in north India. A total 224 patients divided into two groups, one with HIV-TB and the other with HIV alone, were followedup for a minimum period of 3 months. The diagnosis of TB was categorised as ‘‘definitive” and ‘‘probable”. Results. Out of a total of 224 patients, 203 completed followup. Paradoxical TB-IRIS occurred in 5 of 123 (4%) HIV-TB patients while 6 of 80 (7.5%) HIV patients developed ART-associated TB. A reduction in plasma viral load was significantly (P = .016) associated with paradoxical TB-IRIS. No identifiable risk factors were associated with the development of ART-associated TB. Conclusion. The consensus case-definitions are useful tools in the diagnosis of TB-associated IRIS. High index of clinical suspicion is required for an early diagnosis

Evaluation and management of cancer patients presenting with acute cardiovascular disease:a Consensus Document of the Acute CardioVascular Care (ACVC) association and the ESC council of Cardio-Oncology-Part 1: acute coronary syndromes and acute pericardial diseases

Advances in treatment, common cardiovascular (CV) risk factors and the ageing of the population have led to an increasing number of cancer patients presenting with acute CV diseases. These events may be related to the cancer itself or the cancer treatment. Acute cardiac care specialists must be aware of these acute CV complications and be able to manage them. This may require an individualized and multidisciplinary approach. We summarize the most common acute CV complications of cytotoxic, targeted, and immune-based therapies. This is followed by a proposal for a multidisciplinary approach where acute cardiologists work close together with the treating oncologists, haematologists, and radiation specialists, especially in situations where immediate therapeutic decisions are needed. In this first part, we further focus on the management of acute coronary syndromes and acute pericardial diseases in patients with cancer

Statistical process control for autocorrelated data on grid

Assumptions of normality and independence are key assumptions made in the development and use of control charts. However for much industrial data, the assumption of independence is hard to justify. Control charts for the sample mean and sample standard deviation are obtained, when the observations are taken over a grid on a two-dimensional surface. It is assumed that the observations follow an autoregressive process of order one in both the directions. The results have been applied to road pavement data on road corse thickness observed on a two dimensional grid

Gossip Codes for Fingerprinting: Construction, Erasure Analysis and Pirate Tracing

This work presents two new construction techniques for q-ary Gossip codes from t-designs and Traceability schemes. These Gossip codes achieve the shortest code length specified in terms of code parameters and can withstand erasures in digital fingerprinting applications. This work presents the construction of embedded Gossip codes for extending an existing Gossip code into a bigger code. It discusses the construction of concatenated codes and realisation of erasure model through concatenated codes

Security Analysis of Lal and Awasthi\u27s Proxy Signature Schemes

In this paper, we analyze two proxy signatures scheme [1], [2] proposed by Lal and Awasthi and found that both the schemes suffer with the security flaws. The scheme [1] suffers with proxy signer\u27s forgery attacks and misuse of original signer\u27s delegated information. The other scheme [2] suffers with original signer\u27s forgery attack, proxy signer\u27s undeniability and misuse of delegated information

Security analysis of Lal and Awasthi’s proxy signature schemes. Available At http://eprint.iacr.org/2003/263

In this paper, we analyze two proxy signatures scheme [1], [2] proposed by Lal and Awasthi and found that both the schemes suffer with the security flaws. The scheme [1] suffers with proxy signer’s forgery attacks and misuse of original signer’s delegated information. The other scheme [2] suffers with original signer’s forgery attack, proxy signer’s undeniability and misuse of delegated information

A novel remote user authentication scheme using bilinear pairings

The paper presents a remote user authentication scheme using the properties of bilinear pairings. In the scheme, the remote system receives user login request and allows login to the remote system if the login request is valid. The scheme prohibits the scenario of many logged in users with the same login-ID, and provides a flexible password change option to the registered users without any assistance from the remote system.© Elsevie

Structural studies on tobacco streak virus coat protein: Insights into the pleomorphic nature of ilarviruses

Tobacco streak virus (TSV), the type member of Ilarvirus genus, is a major plant pathogen. TSV purified from infected plants consists of a ss-RNA genome encapsidated in spheroidal particles with diameters of 27, 30 and 33 nm constructed from multiple copies of a single species of coat protein (CP) subunits. Apart from protecting the viral genome, CPs of ilarviruses play several key roles in the life cycle of these viruses. Unlike the related bromo and cucumoviruses, ilarvirus particles are labile and pleomorphic, which has posed difficulties in their crystallization and structure determination. In the current study, a truncated TSV-CP was crystallized in two distinct forms and their structures were determined at resolutions of 2.4 angstrom and 2.1 angstrom, respectively. The core of TSV CP was found to possess the canonical beta-barrel jelly roll tertiary structure observed in several other viruses. Dimers of CP with swapped C-terminal arms (C-arm) were observed in both the crystal forms. The C-arm was found to be flexible and is likely to be responsible for the polymorphic and pleomorphic nature of TSV capsids. Consistent with this observation, mutations in the hinge region of the C-arm that reduce the flexibility resulted in the formation of more uniform particles. TSV CP was found to be structurally similar to that of Alfalfa mosaic virus (AMV) accounting for similar mechanism of genome activation in alfamo and ilar viruses. This communication represents the first report on the structure of the CP from an ilarvirus. (C) 2015 Elsevier Inc. All rights reserved

Dissection of Protonation Sites for Antibacterial Recognition and Transport in QacA, a Multi-Drug Efflux Transporter

QacA is a drug:H+ antiporter with 14 transmembrane helices that confers antibacterial resistance to methicillin-resistant Staphylococcus aureus strains, with homologs in other pathogenic organisms. It is a highly promiscuous antiporter, capable of H+-driven efflux of a wide array of cationic antibacterial compounds and dyes. Our study, using a homology model of QacA, reveals a group of six protonatable residues in its vestibule. Systematic mutagenesis resulted in the identification of D34 (TM1), and a cluster of acidic residues in TM13 including E407 and D411 and D323 in TM10, as being crucial for substrate recognition and transport of monovalent and divalent cationic antibacterial compounds. The transport and binding properties of QacA and its mutants were explored using whole cells, inside-out vesicles, substrate-induced H+ release and microscale thermophoresis-based assays. The activity of purified QacA was also observed using proteoliposome-based substrate-induced H+ transport assay. Our results identify two sites, D34 and D411 as vital players in substrate recognition, while E407 facilitates substrate efflux as a protonation site. We also observe that E407 plays an additional role as a substrate recognition site for the transport of dequalinium, a divalent quaternary ammonium compound. These observations rationalize the promiscuity of QacA for diverse substrates. The study unravels the role of acidic residues in QacA with implications for substrate recognition, promiscuity and processive transport in multidrug efflux transporters, related to QacA