6 research outputs found
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Skin is the body�s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.Figure not available: see fulltext
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Skin is the body�s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.Figure not available: see fulltext
Molecular characterization of familial hypercholesterolemia in Iranian patients
Abstract Familial hypercholesterolemia (FH) is an autosomal
dominant disorder of lipoprotein metabolism caused
mainly by mutations in the low-density lipoprotein receptor
(LDLR) and apolipoprotein B 100 (APOB) genes. Until
now, the molecular basis of FH has been demonstrated in
detail in many populations, but there is still very limited
Molecular data concerning FH in Iran. The aim of this study
was to characterize the LDLR and APOB gene mutations in
an Iranian population. A total of 30 non-related Iranian
possible FH subjects were studied. Diagnosis of FH was
based on the Dutch Lipid Clinic Network diagnostic criteria.
All samples were initially tested for three common
APOB gene mutations including R3500Q, R3500 W and
R3531C using PCR-RFLP assay. Subsequently, promoter
and coding region of the LDLR gene was screened by PCRSSCP
analysis and positive results were confirmed by DNA
sequencing. Four previously reported polymorphisms
1413G [A, 1725C [T, 1773T [C and 2140 ? 5G[A
were found in *17% (5/30) of population studied.
Moreover, no variation was found in APOB gene. Our data
indicated that LDLR and APOB gene mutations have not
contribution to possible FH in Iranian population studied
here. However, we examined three common APOB mutations
and LDLR in only 30 patients, and to determine the
role of these genes in developing FH in Iran, more FH
samples and populations needed to be investigated for the
mutations of the related gene
Biopolymer-based scaffolds for corneal stromal regeneration: A review
The stroma is one of the 5 layers of the cornea that comprises more than 90% of the corneal thickness, and is the most important layer for the transparency of cornea and refractive function critical for vision. Any significant damage to this layer may lead to corneal blindness. Corneal blindness refers to loss of vision or blindness caused by corneal diseases or damage, which is the 4th most common cause of blindness worldwide. Different approaches are used to treat these patients. Severe corneal damage is traditionally treated by transplantation of a donor cornea or implantation of an artificial cornea. Other alternative approaches, such as cell/stem cell therapy, drug/gene delivery and tissue engineering, are currently promising in the regeneration of damaged cornea. The aim of tissue engineering is to functionally repair and regenerate damaged cornea using scaffolds with or without cells and growth factors. Among the different types of scaffolds, polymer-based scaffolds have shown great potential for corneal stromal regeneration. In this paper, the most recent findings of corneal stromal tissue engineering are reviewed
Stem cell-based therapeutic strategies for corneal epithelium regeneration
Any significant loss of vision or blindness caused by corneal damages is referred to as corneal blindness. Corneal blindness is the fourth most common cause of blindness worldwide, representing more than 5 of the total blind population. Currently, corneal transplantation is used to treat many corneal diseases. In some cases, implantation of artificial cornea (keratoprosthesis) is suggested after a patient has had a donor corneal transplant failure. The shortage of donors and the side effects of keratoprosthesis are limiting these approaches. Recently, researchers have been actively pursuing new approaches for corneal regeneration because of these limitations. Nowadays, tissue engineering of different corneal layers (epithelium, stroma, endothelium, or full thickness tissue) is a promising approach that has attracted a great deal of interest from researchers and focuses on regenerative strategies using different cell sources and biomaterials. Various sources of corneal and non-corneal stem cells have shown significant advantages for corneal epithelium regeneration applications. Pluripotent stem cells (embryonic stem cells and iPS cells), epithelial stem cells (derived from oral mucus, amniotic membrane, epidermis and hair follicle), mesenchymal stem cells (bone marrow, adipose-derived, amniotic membrane, placenta, umbilical cord), and neural crest origin stem cells (dental pulp stem cells) are the most promising sources in this regard. These cells could also be used in combination with natural or synthetic scaffolds to improve the efficacy of the therapeutic approach. As the ocular surface is exposed to external damage, the number of studies on regeneration of the corneal epithelium is rising. In this paper, we reviewed the stem cell-based strategies for corneal epithelium regeneration
Investigating of Mothers' Behavior Based on the Health Belief Model about Using Iron Supplementation in 6 to 24-Month Old Children in Shahrekord City, Iran.
Background: Anemiais one of the most important problems in children's public health. Iron
Deficiency Anemia is the most common type of anemia among this group. This study was
conducted to determine mothers' behavior based on Health Belief Model about using iron
complementation in 6 to 24 month old children in Shahrekord city.
Original Research Article
Reisi et al.; BJMMR, 5(9): 1140-1146, 2015; Article no.BJMMR.2015.128
1141
Methods: This cross-sectional study was performed in 2013.Eighty three Mothers, with their
children (6- 24 months) participated in the research and completed the questionnaire designed
based on Health Belief Model. Validity and reliability of the questionnaire were confirmed in a pilot
study (a=0.79). The data were analyzed by software SPSS16, Spearman and Pearson correlation
tests.
Results: The mean age of mothers was 28.95±4.05 and most of them (44/6%) graduated from
university. Awareness, sensitivity and perceived severity and also perceived benefits of most
studied cases (59%) were evaluated acceptable. But the attitude of a considerable number of the
cases (41%) towards removing the barriers (perceived barriers) was poor. A lot of studied cases
(34/9%) had poor performance as well. There were significant relationships between awareness,
education, number of children, and performance (p<0.001). There was also a significant inverse
relationship between performance and perceived barriers. (p<0.001, r =- 0.49)
Conclusions: The results showed mothers' poor attitude about removing the barriers which were
existed against giving iron to their children. Since perceived barriers have a significant role in
performance, it can be concluded that this is the cause of mothers' behavior. So, it is necessary to
develop educational programs in this field