Relationship between ionic radius and pressure dependence of ionic conductivity in water

Experimental measurements of ionic conductivity in water are analysed in order to obtain insight into the pressure dependence of limiting ionic conductivity of individual ions (λ0) for ions of differing sizes. Conductivities of individual ions, λ0 do not exhibit the same trend as a function of pressure for all ions. Our analysis suggests that the effect of pressure on ionic conductivity depends on the temperature. At low temperatures, the effect of pressure on relatively small ions such as Li+ exhibit an increase in conductivity with pressure. Intermediate sized ions exhibit an increase in conductivity with increase in pressure initially and then at still higher pressures, a decrease in ionic conductivity is observed. Although there are data at low temperatures for ions of large radius, the effect of increased pressure is expected to lower conductivity with increase in pressure over the whole range. At higher temperatures, the dependence of conductivity on pressure changes and these changes are discussed. Divalent ions such as SO2−4 exhibit different trends as a function of pressure at different temperatures. Both the divalent ions (Ca2+ and SO2−4 ) for which experimental data exists, exhibit an increase with pressure at lower temperatures. At slightly higher temperatures, a maximum in conductivity is seen as a function of pressure over the same range of pressure

Cytotoxicity Effects of Formulated Mangosteen Rind and Grape Seed Extract Against Vero Cells, Breast Cancer and Colon Cancer

Globally, cancer causes millions of deaths in addition to significant social and economic consequences. Even in cases when the level of tolerated therapy has not been reached to suppress the death rate and shorten the duration of survival for metastatic cancer patients, novel therapeutic strategies are being employed, including medications, biological molecules, and immune-mediated therapies. Traditional medical practices relied heavily on plant-derived natural compositions to treat a variety of illnesses. When science-based "modern" medicine first appeared, it was carefully studied if there was any scientific basis for using natural remedies derived from plants to cure ailments. Scientists continued, however, to search for the scientific foundations of medical plants, herbal remedies, and functional foods. Finding therapeutic plant-based active principles has led to significant advancements in the identification and use of natural chemicals for the treatment of many ailments in recent decades.  Mangosteen rind extract and grape seed extract, both high in antioxidants, were mixed as a formulation to explore the cytotoxic effects on breast and colon cancer. The cytotoxicity of MCF-7 and MDA-MB-231 (breast cancer) and HT-29 (colon cancer) was investigated and compared to the standard (Doxorubicin). The findings of the cytotoxicity assays show that the addition of Mangosteen and grape seed extract to MTT assays gradually improved the inhibition of MCF-7, MDA-MB-231, and HT-29 cells. Mangosteen and grape seed extract treatment boosted the fraction of cells undergoing apoptosis in MCF-7, MDA-MB-231, and HT-29 cancer cell lines. Thus, the invitro study results of compounded mangosteen and grape seed extract revealed that they are effective anti-cancer, anti-fungal, anti-bacterial, and antioxidant agents

Pagets disease of uncertain origin: case report

BACKGROUND: Pagets disease of the nipple presents as an eczematous lesion, occurs in 1 – 4% of all female breast carcinoma cases and is invariably associated with underlying malignancy either overt or occult. The majority of these cases are invasive disease although 40–45% are associated with DCIS. CASE PRESENTATION: A 39 year old lady presented to our unit with a palpable lump in the right breast. Radiological and histological investigation proved this to be an extensive area of Ductal Carcinoma in Situ (DCIS) for which she underwent a simple mastectomy and immediate latissimus dorsi flap reconstruction. Histology revealed high grade DCIS with 2 small foci of invasive carcinoma. At 1 year the patient represented with a nodule adjacent to the reconstruction scar which was proved on biopsy to be consistent with Paget's disease. This was proved on formal excision. CONCLUSION: In the absence of underlying breast or apocrine tissue this case details a case of Paget's disease of uncertain origin

Electric Car: A Research Impact BY Means OF Scientometric Analysis

The day-to-day increasing costs of petrol and diesel and to control the air pollution makes an impact to do a scientometric analysis on the research ouput on “Electric Car”. Therefore, the research publications indexed in Web of Science for 28 years have been downloaded from 1991 to 2018 for the analysis. The research reveals that a total of 2424 publications is published during the above-mentioned year. The regression test proves that the deviation among the data is low and has possibility to calculate the doubling time on the basis the last 14 years. The doubling time proves that the growth of publications increased from year after year. Journal articles played a dominant role among other type of publications. The language “English” played prominent role than the other language publications on “Electric Car”. Tang T.Q. published 15 publications and ranked first among the other authors. The Lotka’s Law does not fit the author productivity of the publications published on “Electric Car”. Eventhough, the research publications are increasing from year after year, the number of publications published in the past is not up to remarkable. At the same time, only a very few countries have been implemented the “Electric Car” throughout the world. It is therefore, suggested that the funding agencies, sponsoring bodies and global research and development ministries to encourage the researchers to do many more research on “Electric Car”, to enhance the control of air pollution by means of reducing the consumption of Petrol and Diesel, which will also support the cost control for better economy of the global countries

Understanding and overcoming risks to cooperation along transboundary rivers

This study reviews the experience of cooperation in five international river basins, focusing on the perceptions of risks and opportunities by country decision makers responding to a specific prospect of cooperation, and the effects of risk reduction and opportunity enhancement on the cooperation process. We explore the following five categories of risk: Capacity and Knowledge; Accountability and Voice; Sovereignty and Autonomy; Equity and Access; and Stability and Support. We surmise that risk perception plays a key and less understood role in decision making processes over shared rivers cooperation, and conclude that countries and third parties can best achieve sustainable cooperation when long-term investments are made in risk reduction. We also point to areas for further study to better understand the motivations for cooperation.Keywords: Freshwater agreements, Political opportunity, Perceived risks, Shared rivers, Risk reduction, Transboundary rivers, Cooperation, International waters, Decision makin

Experimental Performance Analysis Of Free And Forced Fully Developed Air Flow Green House Solar Dryer Using Curry Leaves

The world is beginning to move away from its consumption of fossil fuels. Various technologies are being developed to make use of renewable energy sources such as wind, solar, and tidal, etc. Solar energy is the best choice among these sources because of it is readily available, abundant, and capable of producing both electric energy and space heating. Solar energy can be used directly or indirectly to dry agricultural and non-agricultural products to preserve them for long a period without formation of fungi. Drying of herbal leaves is an important process in Siddha and Ayurvedic industries to produce herbal medicines in power form. However, as herbal leaves are dried in the open sun, they are susceptible to environmental factors such as rain, insects, and livestock. These disadvantages of open-air drying shall be overwhelmed by greenhouse solar dryer. Greenhouse solar dryer with natural convection, forced convection with hot air supply are the existing methods, but when supplied with hot air, the rise in temperature leads to nutrient loss in herbal leaves. In order to avoid this loss in nutrients, the current work gives a solution that the temperature of forced convection greenhouse dryer can be reduced and controlled by supplying the ambient air at inlet flow in a fully developed air region, and this method can also leads to reduction in colour loss with possibly same or higher drying rate compare to natural convection greenhouse dryer

Performance Comparison of Tray, Bed and Integrated Drying Chamber in Closed Loop Heat Pump Dryer for Bermuda Grass

Drying plays a crucial role in various industries such as food production, agriculture, Siddha, Ayurveda, and medical fields. To achieve controlled drying conditions, a heat pump dryer is considered an effective method, allowing for precise control of parameters like temperature, humidity, and air velocity. In this study, a heat pump dryer was designed and constructed to investigate the drying characteristics of Bermuda grass (Cynodon dactylon) at different velocities (1.5 m/s, 2.0 m/s, and 2.5 m/s) using three types of drying chambers: fluidized bed dryer, tray dryer, and combined dryer (a combination of bed and tray). The heat pump system utilized R134a as the refrigerant. The performance of the heat pump dryer in the three drying chambers was analyzed using Bermuda grass as the drying product. The Moisture Removal Rate (MRR) was calculated for various combinations of velocity and drying chamber, and it was observed that the combined dryer achieved a higher MRR at all three velocities compared to the tray and fluidized bed dryers

Lymphangiogenesis and lymph node metastasis in breast cancer

<p>Abstract</p> <p>Introduction</p> <p>There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these limitations have been relieved by the discovery of a small number of potential lymphatic-specific markers. The relationship between lymphangiogenesis and regional or distant metastasis has not previously been investigated in humans. Using these lymphatic markers, it is possible to explore the relationship between lymphangiogenesis and tumour metastasis. This study indirectly quantified lymphangiogenesis by measuring mRNA expression of all seven lymphatic markers described above in breast cancers and correlated these markers with lymphatic involvement and survival.</p> <p>The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival.</p> <p>Results</p> <p>There was significantly greater expression of all 7 markers in malignant compared to benign breast tissue. In addition, there was greater expression in lymph node positive/grade 3 tumours when compared to lymph node negative/grade 1 tumours. In 5 of the markers, there was a greater expression in poor NPI prognostic tumours when compared to favourable prognostic tumours which was not statistically significant. There was no association between recurrence risk and lymphangiogenic marker expression.</p> <p>Conclusion</p> <p>In summary, the findings from this study show that lymphangiogenesis, measured by specific lymphatic marker expression, is higher in breast cancers than in normal breast tissue. Secondly, breast cancers which have metastasised to the regional lymphatics show higher expression compared to those which have not, although the individual differences for all five markers were not statistically significant.</p