One step closer to achieving inclusive design: design considerations for clients with low vision

While the low-vision population in America continues to increase, few empirical studies have been completed investigating how environmental factors affect a low-vision person’s ability to perceive the interior environment accurately. By using quantitative research methods to understand the critical relationship between contrast levels within the built environment and the ability of the low-vision and normal-sighted population to perceive that environment accurately, researchers can investigate safer and more inclusive interior spaces. Specifically, this study explores the environmental factor of contrast and how varying levels of contrast within interior spaces might affect the behaviour of low-vision participants within the interior environment. The findings demonstrate a preference among normal-sighted and low-vision participants for high-contrast environments, and their innate cues of high contrast.Peer Reviewe

PHI-010 - Beating the bugs: the role of microbiology tests in antimicrobial stewardship in spinal cord injury units

Background: Antimicrobial Stewardship Programs (ASPs) aim to optimize the prescription of antibiotics to combat antimicrobial resistance (AMR), reduce Clostridioides difficile infections, and lower antibiotic expenditures. Although ASPs are implemented in Veterans Health Administrations (VHAs) in the US, they are not targeted at the Spinal Cord Injury (SCI) population, which, relative to other patient populations, is more vulnerable to AMR. The goals of the study were to (1) assess the effectiveness of microbiology testing as a strategy to combat AMR and (2) assess the potential for collaboration among ASP leaders and SCI prescribers for implementation of ASPs in SCI units in VHAs

Exposure to coronavirus news on mainstream media: The role of risk perceptions and depression

Objective The mainstream media tend to rely on news content that will increase risk perceptions of pandemic outbreaks to stimulate public response and persuade people to comply with preventive behaviours. The objective of this study was to examine associations between exposure to coronavirus disease (COVID-19) news, risk perceptions, and depressive symptoms. Methods Cross-sectional data were collected from 501 participants who were ≥18 years. Exposure to COVID-19 news was assessed as our exposure variable. We screened for depression (outcome variable) with the Patient Health Questionnaire and examined the roles of risk perceptions. Multiple linear regressions and mediation analysis with 1000 bootstrap resamples were conducted. Results Participants were 55.29% female, 67.86% White with mean age 32.44 ± 11.94 years. After controlling for sociodemographic and socio-economic factors, news exposure was positively associated with depressive symptoms β = .11; 95% confidence interval (95%CI) = 0.02–0.20. Mediation analysis showed that perceived vulnerability to COVID-19 mediated 34.4% of this relationship (β = .04; 95%CI = 0.01–0.06). Conclusion Perceived vulnerability to COVID-19 can serve as a pathway through which exposure to COVID-19 news on mainstream media may be associated with depressive symptoms. Based on our findings, we offered recommendations for media–health partnership, practice, and research

Digital Divide Among Caregivers of Chronic Disease Patients

Expansive and rapid growth of technology creates unprecedented patient access to health information, including timely communication with care providers via patient portals and the ability to access information regarding specific disease(s) (e.g., cancer). However, several forms of digital engagement with health providers require access and use of reliable internet access. A “digital divide” is used to describe demographic differences which contribute to a patient’s use or disuse of patient portals; prior research have noted disparities in lack of reliable internet access. Despite the prevalence of informal caregivers in patient care, little is known about internet access and use among informal caregivers of patients with chronic disease. This study leveraged the 2017 Behavioral Risk Factor Surveillance System (BRFSS) dataset to determine population level characteristics of caregiver factors which may contribute to their internet access and use. Findings illuminate informal caregivers primarily care for patients with illnesses relating to aging, including dementia. We also found that non-use of the internet (NUI) was higher among caregiver groups who informally provided care between 20-39 hours/week as opposed to those with 0-8 hours of provided care each week. Unlike caregivers of asthma, cancer and dementia; caregivers of substance use, diabetes, HIV and chronic respiratory disease patients reported higher NUI. Future studies should target the specific needs of informal caregivers such that tools promoting patient engagement and access to resources do not unintentionally neglect this user group

Psychological Pathways Linking Public Trust During the Coronavirus Pandemic to Mental and Physical Well-being

The well-being of the public during the 2019 coronavirus (COVID-19) pandemic is deeply rooted in institutional trust in the government’s risk communication effort. The objective of this study was to examine the psychological pathway through which public trust in the government is associated with mental and physical well-being. We collected cross-sectional data from 501 participants aged ≥18 years using an online panel. Public trust in the government was assessed as our exposure variable. We screened for psychological distress by combining the Patient Health Questionnaire and the General Anxiety Disorder scale. Physical well-being was examined using self-rated health. We further assessed the roles of risk perceptions. The author conducted a one-way analysis of variance (ANOVA), Pearson’s correlations, multivariable regressions, and mediation analyses (using the Preachers and Hayes’ approach). Participants were 55.29% female, 67.86% Caucasian/white with a mean age of 32.44 ± 11.94 years. Public trust in the government regarding COVID-19 was negatively correlated with psychological distress (r = −0.20; p \u3c 0.001) and positively associated with physical well-being (r = 0.13; p \u3c 0.001). After adjusting for sociodemographic and socioeconomic factors, public trust remained negatively associated with psychological distress (β = −0.19; 95% confidence intervals, [CI] −0.30, −0.09) and positively associated with physical well-being (β = 0.26; 95% CI [0.16, −0.37]). Perceived self-efficacy to practice COVID-19 protective behavior partially mediated the relationship between public trust and psychological distress (13.07%); and physical well-being (28.02%). Perceived self-efficacy to protect self against COVID-19 infection can serve as a psychological pathway through which public trust may be associated with mental and physical health. DOI: 10.3389/fpsyg.2020.57021

Intention to Vaccinate Against the Novel 2019 Coronavirus Disease: The Role of Health Locus of Control and Religiosity

The urgency to develop a vaccine against the 2019 coronavirus (COVID-19) has waxed stronger in speed, scale, and scope. However, wisdom dictates that we take a vantage position and start to examine the demographic predictors of COVID-19 vaccine hesitancy. The objective of this study was to examine the role of health locus of control (HLOC) in the relationship between religiosity and COVID-19 vaccination intention. In a cross-sectional survey (N = 501), we found a significantly negative association between religiosity and COVID-19 vaccination intention. This relationship was partially mediated by external HLOC. Collaborative efforts with religious institutions may influence COVID-19 vaccine uptake. Introductio

The Content of COVID-19 Information Searches and Vaccination Intention: An Implication for Risk Communication

Objective: The main objective of this study was to examine the association between COVID-19 information search activities and vaccination intention. Methods: Cross-sectional data were collected using online surveys. Independent variables included COVID-19 information search on the (1) science of viral effects of COVID-19 on the body, (2) origin of COVID-19, (3) symptoms and outcomes, (4) transmission and prevention, (5) future outbreak, and (6) policies/procedures to follow. The outcome variable was vaccination intention. A multivariable regression analysis was conducted. Results: Participants (N = 501) had a mean age of 32.44 ± 11.94 years, were 55.3% female, and 67.9% were white. Most COVID-19 information searches were on symptoms and outcomes (77.7%) and policies/procedures to follow (69.9%). Intention to vaccinate against COVID-19 was higher among participants who searched for information on the science of viral effects of COVID-19 on the body (β = 0.23, 95% CI: 0.03-0.43; P = 0.03) and policies/procedures to follow (β = 0.24, 95% CI: 0.03-0.41; P = 0.02). Conclusions: People who searched for information about (1) the science of viral effects of COVID-19 and (2) policies/procedures recommendations also reported higher vaccination intention. Risk communication seeking to increase vaccination should meet the consumers’ information demand by prioritizing the scientific rationale for COVID-19 vaccination and by clarifying what policies/procedures are recommended

Sellar Remodeling after Surgery for Nonfunctioning Pituitary Adenoma: Intercarotid Distance as a Predictor of Recurrence

Introduction  As they grow, pituitary adenoma can remodel the sella turcica and alter anatomical relationships with adjacent structures. The intercarotid distance (ICD) at the level of the sella is a measure of sella width. The purpose of this study was to (1) assess how ICD changes after transsphenoidal surgery and (2) explore whether the extent of ICD change is associated with tumor recurrence. Methods  A retrospective analysis of preoperative and postoperative coronal magnetic resonance imaging (MRI) scans was carried out by two independent assessors on patients who underwent transsphenoidal surgery for nonfunctioning pituitary macroadenomas. Preoperative tumor volume and any change in ICD following surgery were recorded and compared between groups. Logistic regression models of recurrence were generated. Results  In 36 of 42 patients, ICD fell after surgery (mean = 1.8 mm) and six cases were static. At time of follow-up (mean = 77 months), 25 had not required further intervention and 17 had undergone second surgery or radiosurgery. In patients in whom no further intervention has yet been necessary, the postoperative reduction in ICD was significantly smaller than in those who required repeat intervention (1.1 vs. 2.7 mm respectively, p  < 0.01). ICD decrease was weakly correlated with tumor volume ( r  = 0.35). ICD decrease was a significant predictor of recurrence (odds ratio [OR] = 3.15; 95% confidence interval [CI]: 1.44–6.87), largely independent of tumor volume. Conclusion  For most patients, ICD falls following surgical excision of a nonfunctioning pituitary macroadenoma. A greater reduction in ICD postsurgery appears to predict recurrence. Change in ICD shows promise as a radiographic tool for prognosticating clinical course after surgery

Promoting Teamwork in Translational Medical Teams: Insights and Recommendations from Science and Practice

Translational medical teams are transdisciplinary, highly collaborative, and operate within dynamic environments to solve time-sensitive and complex problems. These teams are tasked with turning observations in the laboratory and clinic into effective interventions that improve the health of individuals and the public. The nature of the problems they seek to solve requires coordination among clinicians, scientists, and experts from various scientific disciplines. Characteristically, translational medical teams have complex compositions, structure, and pluralistic goals, which pose significant challenges and barriers to enacting effective teamwork, compromising team performance. Given these challenges, it is imperative to glean insights from teams research and the science of team science on how to execute efficacious teamwork. Consequently, the purpose of this paper is to discuss specific teamwork processes (i.e., trust, communication, self-correction, backup behavior, shared mental models, and conflict management) that are critical to translational medical team performance and offer mechanisms to better equip such teams. Utilizing a theoretical framework of transdisciplinary teamwork adapted from the science of team science and tailored to translational medical teams, we describe each of these processes, their relation to translational medical team outcomes, and how they can be leveraged to improve teamwork. Such a discussion aims to provide practical guidance for conceptualizing and enhancing teamwork in translational medical teams

PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity

Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulosclerosis. When stimulated by agonists of the histamine H1 receptor (H1R), TRPC6 activity decays to the baseline despite the continuous presence of the agonist. In this study, we examined whether H1R desensitization contributes to regulating the decay rate of TRPC6 activity upon receptor stimulation. We employed the HEK expression system and a biosensor allowing us to simultaneously detect the changes in intracellular diacylglycerol (DAG) and Ca2+ concentrations. We found that the histamine-induced DAG response was biphasic, in which a transient peak was followed by maintained elevated plateau, suggesting that desensitization of H1R takes place in the presence of histamine. The application of PKC inhibitor Gö6983 slowed the decay rate of intracellular DAG concentration. Activation of the mouse H1R mutant lacking a putative PKC phosphorylation site, Ser399, responsible for the receptor desensitization, resulted in a prolonged intracellular DAG increase and greater Mn2+ influx through the TRPC6 channel. Thus, our data support the hypothesis that PKC-dependent H1R phosphorylation leads to a reduced production of intracellular DAG that contributes to TRPC6 activity regulation