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Pharmaceutico-physicochemical validation of Mamajjaka Ghana tablet, a potent antidiabetic medicine

Background: Mamajjaka Ghana Vati is a well-recognized herbal medicine for the treatment of Madhumeha. Instead of its attribute in Madhumeha, it was also therapeutically indicated for antipyretic, anthelmintic, hepatoprotective, and anti-inflammatory activities. Aims and Objective: The objective of the present study was to evaluate the significance of large-scale production of Mamajjaka Ghana tablet and its quality control aspect with a view of its wide range of applicability in therapeutics and ayurvedic pharmaceutical industry. Materials ad Methods: Mamajjaka Ghana tablet was prepared in four batches and the findings were scientifically recorded. In this analytical study, organoleptic and physicochemical evaluations of Mamajjaka decoction, solid aqueous extract (Ghana), and tablet were carried out. Results and Discussion: An average of 38.25 h were required for the preparation of Mamajjaka decoction. The average temperature maintained during the process was 95-100°C. The average yield of decoction was 168.75 L in all the four batches. An average of 11.67 kg of solid aqueous extract (Ghana) was obtained. A total of 46.68 kg of Ghana was obtained from all the four batches. An average of 97.93% of Mamajjaka Ghana tablet was obtained. Conclusion: The data pertaining to large-scale production will be useful for ayurvedic pharmaceutical industry populace to maintain quality, uniformity of dosage, and to sustain the batch-to-batch variation during various pharmaceutical operations, and thus the whole process is validated for 65.28 kg of Mamajjaka Ghana tablet

Synthesis and study of mesomorphic properties of unsymmetrical cyclohexanone-derived bis-chalcones

<p>A series of (2<i>E</i>,6<i>E</i>)-2-(4-<i>n</i>-alkoxybenzylidene)-6-((benzo[<i>d</i>][1,3]dioxol-6-yl)methylene)cyclohexanones were synthesised by stepwise condensation reactions from cyclohexanone. The optical and thermal analysis of the series indicated the mesomorphic properties of some derivatives. The compounds with C7–C16 substituents showed the nematic phases in the range of 90–73°C. The single crystal X-ray analysis confirms the head to tail packing arrangement.</p

Seismological, geodetic, macroseismic and historical context of the 2016 Mw 6.7 Tamenglong (Manipur) India earthquake

The 2016 Mw 6.7 Tamenglong earthquake (in the state of Manipur in northeastern India) on 4 January 2016 at 04:35 Indian Standard Time (3 January, 23:05 UTC) was the strongest earthquake to strike Manipur since 1988. Using data from Indian stations, we constrain the hypocentral depth of the mainshock at 59 &#177; 3.8 km and determine a strike-slip mechanism with a moderate reverse component on a steeply dipping plane. Though coseismic offsets from GPS measurements from four nearby sites were inadequate to provide further constraints on the focal mechanism, they were consistent with the magnitude and hypocentral depth of the earthquake. The epicentre of the mainshock was located 15-km west of the Churachandpur Mao Fault (CMF) but it was unrelated to this structure and was instead a typical intra-slab earthquake within the Indian plate. A strong motion instrument at the Loktak Power Station (LOK), 56-km from the epicentre, recorded a peak ground acceleration (PGA) of 0.027g while a PGA of 0.103g was recorded at Shillong (SHL) at an epicentral distance of 111-km. We also present macroseismic observations from 461 locations in north-eastern India and the adjacent areas for this earthquake. The highest intensities (&#8764;7 EMS) were observed in the Manipur Valley and in the hills to the west while shaking was perceptible as far as Delhi and Jaipur. Lastly, we present a catalogue of 333 felt earthquakes in Manipur from 1588 &#177; 1 CE to 1955 derived from the royal chronicle of the kings of Manipur known as the Cheitharon Kumpapa, discuss important historical earthquakes in the region, and also estimate intensity magnitudes for the 1852 (MI 6.5 &#177; 0.8), 1869 (M_I 7.1 &#177; 0.7), 1880 (M_I 6.3 &#177; 0.7) and 2016 (M_I 6.8 &#177; 0.8) earthquakes

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi