METHOD OF HIGH-FREQUENCY OSCILLATION OF CHEST IN TREATMENT OF CHILDREN WITH RESPIRATORY PATHOLOGY

Authors present an experience of high-frequency oscillation of chest via apparatus ?The Vest Airway Clearance System? in 194 patients from children’s pulmonological hospital. The method was effective in complex treatment of acute and chronic bronchopulmonary pathology. Parameters of oscillations depending on age and type of respiratory pathology are proposed, its effectiveness according to the peak expiratory rate, excursion of chest, pulmonary radiograph are described. Authors give a description of possible unfavorable effects.Key words: children, clearance of airways, high-frequency oscillation of chest.(Voprosy sovremennoi pediatrii — Current Pediatrics. – 2010;9(3):117-120

Hypersensitivity pneumonitis (Exogenous allergic alveolitis) in children

А bibliographical review, based on domestic and foreign data, provides up-to-date information on hypersensitivity pneumonitis (HP, exogenous allergic alveolitis) in children. It presents the current data on epidemiology, etiology, pathogenesis, classification, clinical manifestation, diagnosis, therapy, prevention and prognosis of the disease. A computed tomographic semiotics of HP is described in full details in comparison with data on morphology and histopathological patterns of the disease. This review includes classification criteria for the disease for diagnosis of reliable, probable and possible HPs to be verified. Information on the treatment and prevention of the disease is presented in an evidence-based medicine context. © 2021, Pediatria Ltd.. All rights reserved

РЕЦИДИВИРУЮЩИЙ ПОЛИСИНУСИТ, КАК ВЕДУЩИЙ КЛИНИЧЕСКИЙ ПРИЗНАК МУКОВИСЦИДОЗА. УСПЕШНОЕ ЭНДОНАЗАЛЬНОЕ ПРИМЕНЕНИЕ ПУЛЬМОЗИМА

.(Педиатрическая фармакология. – 2009; 6(5):88-91

Actual problems of neonatal pulmonology

The article presents discussion questions, problems and achievements in newborns pulmonology and contribution of Russian researches to this section of neonatology and pediatrics. Authors assess prospects of obtained results implementation and their scientific and practical significance. The article discusses in detail the most common newborns lung diseases-respiratory distress syndrome, bronchopulmonary dysplasia (BPD) and pneumonia. It illuminates the actual problem of complications and differential diagnosis of BPD with other chronic and interstitial newborns lung diseases, occurring under its «disguise». © 2016, Pediatria Ltd. All rights reserved

Actual problems of neonatal pulmonology

The article presents discussion questions, problems and achievements in newborns pulmonology and contribution of Russian researches to this section of neonatology and pediatrics. Authors assess prospects of obtained results implementation and their scientific and practical significance. The article discusses in detail the most common newborns lung diseases-respiratory distress syndrome, bronchopulmonary dysplasia (BPD) and pneumonia. It illuminates the actual problem of complications and differential diagnosis of BPD with other chronic and interstitial newborns lung diseases, occurring under its «disguise». © 2016, Pediatria Ltd. All rights reserved

Нейроэндокринная гиперплазия младенцев: обзор литературы и серия наблюдений

Neuroendocrine hyperplasia of infancy (NEHI) is a rare disease of unknown etiology, which is observed in children of the first 2 years of life, characterized by persistent tachypnea syndrome and such nonspecific changes in lung biopsy as hyperplasia of bombesin-positive neuroendocrine cells of the peripheral respiratory tract. The article provides data on pathogenesis, clinical, morphological and image-diagnostics of this rare lung disease. It also presents data on observations of 26 patients with NEHI.Нейроэндокринная гиперплазия младенцев (НЭГМ) - редкое заболевание неизвестной этиологии, наблюдающееся у детей первых 2 лет жизни, характеризующееся наличием синдрома персистирующего тахипноэ и неспецифических изменений при биопсии легких в виде гиперплазии бомбезин-позитивных нейроэндокринных клеток периферических дыхательных путей. Приведены данные о патогенезе, клинической, морфологической и имидж-диагностике данного редкого заболевания легких. В статье представлены данные о наблюдениях за 26 пациентами с НЭГМ

CLINICAL DIAGNOSIS SCALE FOR NEUROENDOCRINE CELL HYPERPLASIA IN INFANTS: INFORMATIVENESS AND DIFFERENTIAL DIAGNOSTIC SIGNIFICANCE

Neuroendocrine cell hyperplasia of infancy (NEHI) is an interstitial lung disease of unknown etiology that develops in the first year of life and manifests itself as persistent tachypnea syndrome. The aim of the study was to determine the diagnostic value of the clinical scale for the diagnosis of NEHI in comparison with computed tomography (CT) data of the chest organs and for differential diagnosis with acute bronchiolitis (AB)/community-acquired pneumonia (CAP). Materials and methods of research: a multicenter case-control study of children aged 21 days of life to 12 months was carried out: – 83 children with NEHI and 83 infants with AB or CAP. To determine the sensitivity and specificity of this scale for differential diagnosis with AB/CAP, the results of the assessment according to the proposed scale were compared in patients with NEHI (study group) and patients with AB/CAP (control group) on the day of treatment and after 3 weeks. Results: the sensitivity of the clinical scale for the diagnosis of NEHI when compared with the CT data of the chest organs was 85.5%. In the differential diagnosis of NEHI with AB/CAP on the day of treatment, the sensitivity of the clinical scale for the diagnosis of NEHI was 85.5%, the specificity was 80.7%; when re-evaluated after 3 weeks, the accuracy of the scale increased from 83.1% to 91.6%, the specificity – from 80.7% to 97.6%. Diagnosis on a scale after 3 weeks reduced the possibility of overdiagnosis of NEHI from 19.3% to 2.4%. Conclusions: the clinical scale for the diagnosis of NEHI has a high diagnostic value in comparison with the results of CT scan of the chest organs and for differential diagnosis with AB/CAP, especially when re-evaluating. © 2022, Pediatria Ltd. All rights reserved

Нейроэндокринная гиперплазия младенцев: обзор литературы и серия наблюдений

Neuroendocrine hyperplasia of infancy (NEHI) is a rare disease of unknown etiology, which is observed in children of the first 2 years of life, characterized by persistent tachypnea syndrome and such nonspecific changes in lung biopsy as hyperplasia of bombesin-positive neuroendocrine cells of the peripheral respiratory tract. The article provides data on pathogenesis, clinical, morphological and image-diagnostics of this rare lung disease. It also presents data on observations of 26 patients with NEHI.Нейроэндокринная гиперплазия младенцев (НЭГМ) - редкое заболевание неизвестной этиологии, наблюдающееся у детей первых 2 лет жизни, характеризующееся наличием синдрома персистирующего тахипноэ и неспецифических изменений при биопсии легких в виде гиперплазии бомбезин-позитивных нейроэндокринных клеток периферических дыхательных путей. Приведены данные о патогенезе, клинической, морфологической и имидж-диагностике данного редкого заболевания легких. В статье представлены данные о наблюдениях за 26 пациентами с НЭГМ

Issues of diagnosis and management of patients with neuroendocrine cell hyperplasia of infancy

Neuroendocrine hyperplasia of infancy (NEHI) is an interstitial lung disease (ILD) of unknown etiology, which develops in infancy and manifests as persistent tachypnea. Objective of the research: to summarize results of observations of patients with NEHI, including during the pandemic of a new coronavirus infectious disease (COVID-19). Materials and methods: clinical and follow-up observation, laboratory and instrumental examination, including lung biopsy, 52 children with NEHI aged from 21 days to 10 years. Results: NEHI more often affects boys in the first 6 months of life; can be diagnosed on the basis of pediatric ILD-syndrome detection; specific CT signs, lung biopsy. It is characterized by undulating course with increased respiratory failurec aused by acute respiratory viral infections, COVID-19; half of the patients need oxygen therapy. © 2020, Pediatria Ltd.. All rights reserved