2 research outputs found
Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties
Electroconductive
hydrogels are used in a wide range of biomedical
applications, including electrodes for patient monitoring and electrotherapy,
or as biosensors and electrochemical actuators. Approaches to design
electroconductive hydrogels are often met with low biocompatibility
and biodegradability, limiting their potential applications as biomaterials.
In this study, composite hydrogels were prepared from a conducting
polymer complex, polyÂ(3,4-ethylenedioxythiophene):polystyrenesulfonate
(PEDOT:PSS) dispersed within a photo-crosslinkable naturally derived
hydrogel, gelatin methacryloyl (GelMA). To determine the impact of
PEDOT:PSS loading on physical and microstructural properties and cellular
responses, the electrical and mechanical properties, electrical properties,
and biocompatibility of hydrogels loaded with 0–0.3% (w/v)
PEDOT:PSS were evaluated and compared to GelMA control. Our results
indicated that the properties
of the hydrogels, such as mechanics, degradation, and swelling, could
be tuned by changing the concentration of PEDOT:PSS. In particular,
the impedance of hydrogels decreased from 449.0 kOhm for control GelMA
to 281.2 and 261.0 kOhm for hydrogels containing 0.1% (w/v) and 0.3%
(w/v) PEDOT:PSS at 1 Hz frequency, respectively. In addition, an <i>ex vivo</i> experiment demonstrated that the threshold voltage
to stimulate contraction in explanted abdominal tissue connected by
the composite hydrogels decreased from 9.3 ± 1.2 V for GelMA
to 6.7 ± 1.5 V and 4.0 ± 1.0 V for hydrogels containing
0.1% (w/v) and 0.3% (w/v) PEDOT:PSS, respectively. <i>In vitro</i> studies showed that composite hydrogels containing 0.1% (w/v) PEDOT:PSS
supported the viability and spreading of C2C12 myoblasts, comparable
to GelMA controls. These results indicate the potential of our composite
hydrogel as an electroconductive biomaterial
Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties
Electroconductive
hydrogels are used in a wide range of biomedical
applications, including electrodes for patient monitoring and electrotherapy,
or as biosensors and electrochemical actuators. Approaches to design
electroconductive hydrogels are often met with low biocompatibility
and biodegradability, limiting their potential applications as biomaterials.
In this study, composite hydrogels were prepared from a conducting
polymer complex, polyÂ(3,4-ethylenedioxythiophene):polystyrenesulfonate
(PEDOT:PSS) dispersed within a photo-crosslinkable naturally derived
hydrogel, gelatin methacryloyl (GelMA). To determine the impact of
PEDOT:PSS loading on physical and microstructural properties and cellular
responses, the electrical and mechanical properties, electrical properties,
and biocompatibility of hydrogels loaded with 0–0.3% (w/v)
PEDOT:PSS were evaluated and compared to GelMA control. Our results
indicated that the properties
of the hydrogels, such as mechanics, degradation, and swelling, could
be tuned by changing the concentration of PEDOT:PSS. In particular,
the impedance of hydrogels decreased from 449.0 kOhm for control GelMA
to 281.2 and 261.0 kOhm for hydrogels containing 0.1% (w/v) and 0.3%
(w/v) PEDOT:PSS at 1 Hz frequency, respectively. In addition, an <i>ex vivo</i> experiment demonstrated that the threshold voltage
to stimulate contraction in explanted abdominal tissue connected by
the composite hydrogels decreased from 9.3 ± 1.2 V for GelMA
to 6.7 ± 1.5 V and 4.0 ± 1.0 V for hydrogels containing
0.1% (w/v) and 0.3% (w/v) PEDOT:PSS, respectively. <i>In vitro</i> studies showed that composite hydrogels containing 0.1% (w/v) PEDOT:PSS
supported the viability and spreading of C2C12 myoblasts, comparable
to GelMA controls. These results indicate the potential of our composite
hydrogel as an electroconductive biomaterial