716 research outputs found
The role of filler wire and scanning strategy in laser welding of difficult-to-weld aluminum alloys
Laser welding of dissimilar aluminum alloys has gained interest over recent years, especially for the production of lightweight components. Pore and crack formation is one of the most critical factors to be taken into consideration for such applications, in particular when one or more parts are produced by die casting or additive manufacturing (AM). Current laser systems offer several methods for defect reduction and process control, while optimized process strategies must be correlated to key factors influencing welding outcomes. In light of these aspects, the current paper investigates the welding of AA6082 sheets with AlSi10Mg parts produced by AM in a lap-joint configuration typical of battery housings in the e-mobility industry. Both laser welding with and without filler wire are investigated, along with the potential advantages of using a wobbling scanning strategy, in order to understand the impact of process strategies on weld bead quality. The importance of process parameter optimization is highlighted for all of the employed strategies, with special emphasis on defects, weld bead chemical composition, joint morphology, and dilution between the materials involved. The findings demonstrate that by introducing filler wire and employing active wobbling, highly reflective alloys can be welded correctly (porosity below 1%, equivalent ultimate strength up to 204 MPa) with good tolerance to variations in process parameters, while filler wire can be excluded in high-productivity welding where linear scanning is employed and detailed optimization of process parameters is performed (porosity below 2%, equivalent ultimate strength up to 190 MPa
Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis.
Chemical Composition and Anti-Inflammatory Activity of the Essential Oil from the Leaves of Male and Female Specimens of Baccharis punctulata DC.
Unravelling species and pathotypes diversity of Pyricularia blast pathogens affecting wheat and grasses in Minas Gerais Cerrado, Brazil.
Long-term survival of stage I multiple myeloma given chemotherapy just after diagnosis or at progression of the disease: a multicentre randomized study
We conducted a randomized trial to evaluate whether melphalan-prednisone (MPH-P) treatment administered just after diagnosis improves survival of stage I multiple myeloma (MM). Between January 1987 and March 1993, 145 consecutive previously untreated patients with stage I MM were randomized between treatment with MPH-P (administered for 4 days every 6 weeks) just after diagnosis and treatment only at disease progression. Survival was not influenced by MPH-P treatment either administered just after diagnosis or at disease progression (64 vs 71 months respectively). Comparing the first with the second group the odds ratio of death is 1.17 (95% confidence interval 0.57–2.42;P = 0.64). Disease progression occurred within a year in about 50% of patients who were initially untreated. Response rate was similar in both groups, but duration of response was shorter in patients who were treated at disease progression (48 vs 79 months, P = 0.044). Patients actually treated at disease progression (34/70) survived shorter than those who had neither disease progression nor treatment (56 vs > 92 months;P = 0.005). Starting MPH-P just after diagnosis does not improve survival and response rate in stage I MM, with respect to deferring therapy until disease progression. However, patients with stage I MM randomized to have treatment delayed and who actually progressed and were treated had shorter survival than those with stable disease and no treatment. Biologic or other disease features could identify these subgroups of patients. © 2000 Cancer Research Campaig
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