ANTIRETROVIRAL THERAPY AND THE RISK OF LIVER FIBROSIS PROGRESSION IN HIV/HCV COINFECTED PATIENTS

The purpose of the study is to determine the nature of the impact of antiretroviral therapy on the development of liver fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), depending on the order of pathogens acquisition. The fact is that the HIV/HCV coinfection is one of the most common pathological conditions worldwide and liver disease is a major cause of death for these patients. We have previously described the phenomenon, according to which the order of viral pathogens acquisition in HIV/HCV coinfected patients has a significant impact on the degree of progression of liver fibrosis. Introduction to clinical practice of antiretroviral therapy greatly increased the life expectancy of HIV-infected patients, however, the impact of ART on a progressive course of liver fibrosis in HIV/HCV coinfected patients have not yet been definitively established

ANTIRETROVIRAL THERAPY AND THE RISK OF LIVER FIBROSIS PROGRESSION IN HIV/HCV COINFECTED PATIENTS

The purpose of the study is to determine the nature of the impact of antiretroviral therapy on the development of liver fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), depending on the order of pathogens acquisition. The fact is that the HIV/HCV coinfection is one of the most common pathological conditions worldwide and liver disease is a major cause of death for these patients. We have previously described the phenomenon, according to which the order of viral pathogens acquisition in HIV/HCV coinfected patients has a significant impact on the degree of progression of liver fibrosis. Introduction to clinical practice of antiretroviral therapy greatly increased the life expectancy of HIV-infected patients, however, the impact of ART on a progressive course of liver fibrosis in HIV/HCV coinfected patients have not yet been definitively established

Сравнительная характеристика единиц концентрации применительно к стандартным образцам для газохроматографического анализа углеводородных проб

Application of a method of absolute calibration relating to gas chromatography analysis of liquid hydrocarbon samples is considered. It is shown for this task that both from theoretical, and practical points of view the optimum concentration unit is mass (not molar) fraction. Information on average molar mass of the analyzed sample is necessary for the determination of analytes in liquid hydrocarbon samples in terms of mole fraction. Meanwhile, the normative documents of rather high rank (ASTM, ISO, GOST, GOST R) concerning methods of the determination of average molar weight of samples of such a kind are absent.Рассмотрено применение метода абсолютной градуировки применительно к анализу жидкого углеводородного сырья и продукции методом газовой хроматографии. Показано, что как с теоретической, так и с практической точки зрения при решении данной задачи оптимальными единицами концентраций являются массовые (а не молярные) доли. Для определения содержания компонентов в жидком углеводородном сырье и продукции в единицах молярной доли необходима информация о средней молярной массе анализируемого образца. Между тем нормативные документы достаточно высокого ранга (ASTM, ISO, ГОСТ, ГОСТ Р), регламентирующие методики определения средней молярной массы, отсутствуют