Inflation with Ω≠1\Omega \not = 1

We discuss various models of inflationary universe with $\Omega \not = 1$. A homogeneous universe with $\Omega > 1$ may appear due to creation of the universe "from nothing" in the theories where the effective potential becomes very steep at large $\phi$, or in the theories where the inflaton field $\phi$ nonminimally couples to gravity. Inflation with $\Omega < 1$ generally requires intermediate first order phase transition with the bubble formation, and with a second stage of inflation inside the bubble. It is possible to realize this scenario in the context of a theory of one scalar field, but typically it requires artificially bent effective potentials and/or nonminimal kinetic terms. It is much easier to obtain an open universe in the models involving two scalar fields. However, these models have their own specific problems. We propose three different models of this type which can describe an open homogeneous inflationary universe.Comment: 29 pages, LaTeX, parameters of one of the models are slightly modifie

From the Big Bang Theory to the Theory of a Stationary Universe

We consider chaotic inflation in the theories with the effective potentials phi^n and e^{\alpha\phi}. In such theories inflationary domains containing sufficiently large and homogeneous scalar field \phi permanently produce new inflationary domains of a similar type. We show that under certain conditions this process of the self-reproduction of the Universe can be described by a stationary distribution of probability, which means that the fraction of the physical volume of the Universe in a state with given properties (with given values of fields, with a given density of matter, etc.) does not depend on time, both at the stage of inflation and after it. This represents a strong deviation of inflationary cosmology from the standard Big Bang paradigm. We compare our approach with other approaches to quantum cosmology, and illustrate some of the general conclusions mentioned above with the results of a computer simulation of stochastic processes in the inflationary Universe.Comment: No changes to the file, but original figures are included. They substantially help to understand this paper, as well as eternal inflation in general, and what is now called the "multiverse" and the "string theory landscape." High quality figures can be found at http://www.stanford.edu/~alinde/LLMbigfigs

Basic kinetic wealth-exchange models: common features and open problems

We review the basic kinetic wealth-exchange models of Angle [J. Angle, Social Forces 65 (1986) 293; J. Math. Sociol. 26 (2002) 217], Bennati [E. Bennati, Rivista Internazionale di Scienze Economiche e Commerciali 35 (1988) 735], Chakraborti and Chakrabarti [A. Chakraborti, B. K. Chakrabarti, Eur. Phys. J. B 17 (2000) 167], and of Dragulescu and Yakovenko [A. Dragulescu, V. M. Yakovenko, Eur. Phys. J. B 17 (2000) 723]. Analytical fitting forms for the equilibrium wealth distributions are proposed. The influence of heterogeneity is investigated, the appearance of the fat tail in the wealth distribution and the relaxation to equilibrium are discussed. A unified reformulation of the models considered is suggested.Comment: Updated version; 9 pages, 5 figures, 2 table

Distribution and seasonal evolution of supraglacial lakes on Shackleton Ice Shelf, East Antarctica

Supraglacial lakes (SGLs) enhance surface melting and can flex and fracture ice shelves when they grow and subsequently drain, potentially leading to ice shelf disintegration. However, the seasonal evolution of SGLs and their influence on ice shelf stability in East Antarctica remains poorly understood, despite some potentially vulnerable ice shelves having high densities of SGLs. Using optical satellite imagery, air temperature data from climate reanalysis products and surface melt predicted by a regional climate model, we present the first long-term record (2000–2020) of seasonal SGL evolution on Shackleton Ice Shelf, which is Antarctica's northernmost remaining ice shelf and buttresses Denman Glacier, a major outlet of the East Antarctic Ice Sheet. In a typical melt season, we find hundreds of SGLs with a mean area of 0.02 km2, a mean depth of 0.96 m and a mean total meltwater volume of 7.45×106 m3. At their most extensive, SGLs cover a cumulative area of 50.7 km2 and are clustered near to the grounding line, where densities approach 0.27 km2 km−2. Here, SGL development is linked to an albedo-lowering feedback associated with katabatic winds, together with the presence of blue ice and exposed rock. Although below-average seasonal (December–January–February, DJF) temperatures are associated with below-average peaks in total SGL area and volume, warmer seasonal temperatures do not necessarily result in higher SGL areas and volumes. Rather, peaks in total SGL area and volume show a much closer correspondence with short-lived high-magnitude snowmelt events. We therefore suggest seasonal lake evolution on this ice shelf is instead more sensitive to snowmelt intensity associated with katabatic-wind-driven melting. Our analysis provides important constraints on the boundary conditions of supraglacial hydrology models and numerical simulations of ice shelf stability

Selenoprotein expression in the rat colon during Se deficiency.

Selenium is an essential trace element, which is present in several proteins, called seleneproteins, that have various biological roles

Selenoprotein gene expression in an intestinal cell line during selenium depletion: a macroarray approach indicates effects on SelW and glutathione peroxidise 1.

The micronutrient selenium (Se) is incoprprated into a renage of selenoproteins involved in numerous biochemical processes within the body

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target for glaucoma therapy. Our study helps to better understand underlying genetic and molecular mechanisms that regulate intraocular pressure, and identifies a new candidate gene, Cacna2d1, that modulates intraocular pressure and a promising therapeutic, pregabalin, which binds to CACNA2D1 protein and lowers intraocular pressure significantly. Because our study utilizes a genetically diverse population of mice with kno