Serum 25-Hydroxy Vitamin D Levels in Patients with Acute Hepatitis (Ischemic, Toxic, and Viral): Association With Clinical Progression and Mortality

WOS: 000398932800005Objective: Vitamin D is a key regulator of calcium homeostasis and has anti-inflammatory and immunomodulatory effects. Active vitamin D has a direct effect on T cells and antigen-presenting cells. It also suppresses the differentiation of B cells to plasma cells and inhibits immunoglobulin production. Vitamin D supplementation is associated with a favorable outcome in chronic inflammatory diseases. In this study, we aimed to determine serum vitamin D levels in patients with acute toxic, ischemic, or viral hepatitis and whether the levels had an effect on clinical progression or mortality in patients with acute hepatitis. Methods: Forty-eight patients (26 men and 22 women) and 35 controls (16 men and 19 women) aged > 18 years who were diagnosed as having acute hepatitis and hospitalized in the Internal Medicine Department were enrolled. To determine serum 25-hydroxy (OH) vitamin D levels, two fasting blood samples, first in the initial 24-48 h following hospitalization and second on the day of discharge, were obtained from the participants. The SPSS Statistics v21.0 software was used for the quantitative evaluation of data. Results: Serum vitamin D levels were significantly lower in the patient group (10.0+/-8.7) than in the control group (31.5+/-12.2), but no significant difference was detected in serum vitamin D levels among the patients. Serum vitamin D levels, except in patients with viral hepatitis, were low at discharge. Serum vitamin D levels were lower than the cutoff values in two patients with early mortality. Conclusion: We demonstrated that serum vitamin D levels had no effect on clinical progression of acute hepatitis. Other prospective studies with large sample sizes are required to determine whether serum vitamin D levels can be used to predict clinical progression or mortality

Evaluation of cognitive functions and the related factors in 50-80 year type 2 diabetic subjects

To study cognitive functions in 50-80 year aged type 2 diabetic patients. Cognitive performance was evaluated through a mini mental test (MMT) in 131 patients between 50 and 80 years (100 type 2 diabetics and 31 non-diabetics). Relation analysis were carried out for different parameters. Scores in registration and recall were significantly lower in diabetic group. The effect of HbA1c, body mass index (BMI) and age variables on MMT score was statistically significant. A negative linear correlation was estimated between MMT score and age, HbA1c level and BMI value. HbA1c, age and BMI were inversely related to cognitive functions. MMT scores were 24.98 +/- 3.10 in diabetic group and 25.35 +/- 3.22 in control group and statistically no significant difference was found. No significant difference was between type 2 diabetics and non-diabetics in terms of cognitive functions. But performance of diabetic patients in relation to the registration and recall was lower. Poor glycemic control and obesity in diabetics negatively affect cognitive performance

THE RELATIONSHIP OF VITAMIN D LEVELS WITH EARLY MORTALITY IN PATIENTS WITH ACUTE CORONARY SYNDROME AND VALUE OF VITAMIN D LEVELS AS A CARDIOVASCULAR RISK FACTOR

Objective: Acute coronary syndrome (ACS) is the main cause of mortality and morbidity worldwide. This study aims to determine the serum vitamin D level in patients with ACS, determine whether the serum 25-hydroxy-vitamin D level is associated with the ACS and to investigate whether serum vitamin D level is effective on early (first 30 days after diagnosis) mortality in patients with ACS, or not

Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients

Objectives: Exocrine pancreatic dysfunction may contribute to malnutrition and lack of appetite in the advanced stages of heart failure. Nutritional assessment was carried out on patients diagnosed with mild or moderate/severe heart failure. Fecal elastase levels are an indicator of pancreatic exocrine function and ghrelin is an appetite hormone which is also investigated for its contribution to malnutrition

Serum 25-Hydroxy Vitamin D Levels in Patients with Acute Hepatitis (Ischemic, Toxic, and Viral): Association With Clinical Progression and Mortality

Objective: Vitamin D is a key regulator of calcium homeostasis and has anti-inflammatory and immunomodulatory effects. Active vitamin D has a direct effect on T cells and antigen-presenting cells. It also suppresses the differentiation of B cells to plasma cells and inhibits immunoglobulin production. Vitamin D supplementation is associated with a favorable outcome in chronic inflammatory diseases. In this study, we aimed to determine serum vitamin D levels in patients with acute toxic, ischemic, or viral hepatitis and whether the levels had an effect on clinical progression or mortality in patients with acute hepatitis