Faculty Status for Academic Librarians: A Case Study at the University of Washington

Through a University of Washington case study evaluating a proposed transition to faculty status for all University of Washington librarians, this paper seeks to illustrate some of the many complexities associated with the issue of faculty status for all academic librarians, including law librarians. Among other considerations and lessons specific to the issue of librarian faculty status, two key takeaways for new academic librarians are highlighted

Substance Use Disorder Stigma: What It Is and How You Can Prevent It

This fact sheet describes substance use disorder stigma, what it is and how you can deal with it. It includes definition of common forms, how individuals experience it, steps to better understand it, what it looks like, and how to support someone with a SUD

Survey of nucleon electromagnetic form factors

A dressed-quark core contribution to nucleon electromagnetic form factors is calculated. It is defined by the solution of a Poincare' covariant Faddeev equation in which dressed-quarks provide the elementary degree of freedom and correlations between them are expressed via diquarks. The nucleon-photon vertex involves a single parameter; i.e., a diquark charge radius. It is argued to be commensurate with the pion's charge radius. A comprehensive analysis and explanation of the form factors is built upon this foundation. A particular feature of the study is a separation of form factor contributions into those from different diagram types and correlation sectors, and subsequently a flavour separation for each of these. Amongst the extensive body of results that one could highlight are: r_1^{n,u}>r_1^{n,d}, owing to the presence of axial-vector quark-quark correlations; and for both the neutron and proton the ratio of Sachs electric and magnetic form factors possesses a zero.Comment: 43 pages, 17 figures, 12 tables, 5 appendice

EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming

Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represent a major hurdle in improving the management of clear cell renal cell carcinoma (ccRCC). Recent reports suggest that drug resistance is driven by tumor adaptation via epigenetic mechanisms that activate alternative survival pathways. The histone methyl transferase EZH2 is frequently altered in many cancers including ccRCC. To evaluate its role in ccRCC resistance to RTKi, we established and characterized a spontaneously metastatic, patient-derived xenograft (PDX) model that is intrinsically resistant to the RTKI sunitinib but not to the VEGF therapeutic antibody bevacizumab. Sunitinib maintained its anti-angiogenic and anti-metastatic activity but lost its direct anti-tumor effects due to kinome reprogramming, which resulted in suppression of pro- apoptotic and cell cycle regulatory target genes. Modulating EZH2 expression or activity suppressed phosphorylation of certain RTK, restoring the anti-tumor effects of sunitnib in models of acquired or intrinsically resistant ccRCC. Overall, our results highlight EZH2 as a rational target for therapeutic intervention in sunitinib-resistant ccRCC as well as a predictive marker for RTKi response in this disease.This research was funded by Roswell Park Cancer Institute’s Cancer Center Support Grant from National Cancer Institute, NIH P30CA016056 (RP) and a generous donation by Richard and Deidre Turner (RP). This investigation was conducted in-part in a facility constructed with support from Research Facilities Improvement Program Grant Number C06 RR020128-01 from the National Center for Research Resources, National Institutes of Health

Reducing Inadvertent Perioperative Hypothermia through Education and Protocol

Reducing Inadvertent Perioperative Hypothermia Through Education and Protocol Provision Capstone Leader: Ashley Arrington, SRNA Baptist Health Murray State University Program of Anesthesia, Madisonville, KY Keywords: Inadvertent, Perioperative, Hypothermia, Normothermia, Thermal Management Background: Inadvertent perioperative hypothermia occurs as a result of the body’s inability to effectively regulate temperature following the induction of general anesthesia. Other factors contributing to the body’s ability to maintain normothermia include exposure to cold ambient temperatures in the operating room, infusion of cold intravenous fluids, as well as open body cavities. A consensus exists that there is a correlation between perioperative hypothermia and adverse outcomes including impaired coagulation, altered drug metabolism, post-operative wound infection as well as cardiovascular complications. Objectives: The purpose of this capstone project was to reduce the incidence of inadvertent perioperative hypothermia through education and provision of a perioperative protocol to guide clinicians in avoidance of inadvertent perioperative hypothermia. Process: CRNAs and anesthesiologists from a rural hospital in the Midwestern United States (n=7) participated in a pretestto determine their current knowledge of inadvertent perioperative hypothermia. Education regarding inadvertent perioperative hypothermia, its adverse effects as well as types of thermal management then followed. The participants then completed a post-test to determine the effectiveness of the educational session. The capstone leader developed a protocol and materials for use in a retrospective chart review by the hospital’s OR and anesthesia staff, to guide practice in avoidance of hypothermia in surgical patients. Outcomes: Following completion of the educational session, the CRNAs stated on the post-test that their current thermal management practice would change and the educational session was very beneficial and applicable to practice. A post-test also revealed that their knowledge of inadvertent perioperative hypothermia and thermal management of a surgical patient had significantly improved. The formal protocol was not implemented at the conclusion of the project, in lieu of surgical services management priority initiatives. However, the anesthesia team has retained copies of the protocol and chart review materials to prepare for planned implementation in the future