Atypical umbilical naevi: histopathological analysis of 20 cases

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110566/1/his12503.pd

Acquired hemoglobin C secondary to transfusion with antigen‐matched red blood cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107569/1/jca21306.pd

Rosette‐like structures in the spectrum of spitzoid tumors

Background Spitz nevi demonstrate a diverse spectrum of morphologies. Recently, there have been two reported examples of Spitz nevi with rosette‐like structures similar to Homer‐Wright rosettes. Rosettes have also been described in melanomas and in a proliferative nodule arising in a congenital nevus. Methods A retrospective review of 104 cases of Spitz nevi and variants (n = 51), pigmented spindle cell nevi (n = 26), combined melanocytic nevi with features of Spitz (n = 8), atypical Spitz tumor ( AST , n = 9), and spitzoid melanoma (n = 10). Results Rosette‐like structures were present in 3 of the 104 cases (2.9%), including a compound Spitz nevus, a desmoplastic Spitz nevus, and an AST . All three cases demonstrated several foci of small nests of epithelioid cells with peripherally palisaded nuclei arranged around a central area of fibrillar eosinophilic cytoplasm. Immunohistochemical staining of the three spitzoid lesions demonstrated that the rosette‐like structures express S100 protein, Melan‐A, and neuron specific enolase ( NSE ) and lacked expression of neurofilament, glial fibrillary acidic protein and synaptophysin. Conclusions While uncommon, rosette‐like structures can occur as a focal feature in Spitz nevi and AST . Rosette‐like structures may represent a normal morphologic finding in Spitz nevi, and awareness of them may prevent misdiagnosis as a neural tumor or melanoma.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99651/1/cup12192.pd

Comprehensive histopathological comparison of epidermotropic/dermal metastatic melanoma and primary nodular melanoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141829/1/his13384.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141829/2/his13384_am.pd

Expression of the p40 isoform of p63 has high specificity for cutaneous sarcomatoid squamous cell carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109645/1/cup12387.pd

Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111956/1/cup12469.pd

Characteristics, Therapies, and Outcomes of In-Hospital vs Out-of-Hospital Cardiac Arrest in Patients Presenting to Cardiac Intensive Care Units: From the Critical Care Cardiology Trials Network (CCCTN).

BACKGROUND: Cardiac arrest (CA) is a common reason for admission to the cardiac intensive care unit (CICU), though the relative burden of morbidity, mortality, and resource use between admissions with in-hospital (IH) and out-of-hospital (OH) CA is unknown. We compared characteristics, care patterns, and outcomes of admissions to contemporary CICUs after IHCA or OHCA. METHODS: The Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs in the US and Canada. Participating centers contributed data from consecutive admissions during 2-month annual snapshots from 2017 to 2021. We analyzed characteristics and outcomes of admissions by IHCA vs OHCA. RESULTS: We analyzed 2,075 admissions across 29 centers (50.3% IHCA, 49.7% OHCA). Admissions with IHCA were older (median 66 vs 62 years), more commonly had coronary disease (38.3% vs 29.7%), atrial fibrillation (26.7% vs 15.6%), and heart failure (36.3% vs 22.1%), and were less commonly comatose on CICU arrival (34.2% vs 71.7%), p CONCLUSION: Despite a greater burden of comorbidities, CICU admissions after IHCA have lower lactate, greater invasive therapy utilization, and lower crude mortality than admissions after OHCA