L’art de résister :de la pratique théâtrale à la lutte pour la reconnaissance dans les favelas de Rio de Janeiro

Face aux différentes formes de violences et de stigmatisation présentes dans les favelas de Rio de Janeiro, de nouveaux modes de résistance s’organisent. Les formes classiques de mobilisations populaires se voient bousculées par des mouvements de contestation qui prennent appui sur de nouveaux outils de résistance. La pratique artistique et en particulier le théâtre jouent un rôle important dans ce domaine, en créant des espaces de dialogue, de transmission et de conscientisation. À partir de données empiriques récoltées durant une enquête de terrain de six mois dans le complexe de favelas de la Maré à Rio de Janeiro, notre travail propose de comprendre comment la pratique du Théâtre de l’Opprimé peut mener les actrices et acteurs favelados à entrer dans une lutte pour la reconnaissance de leurs droits. En s’appuyant sur un cadre théorique articulé autour de la théorie de la lutte pour la reconnaissance, cette recherche appréhende le rapport entre art, politisation et engagement militant, dans un espace marqué par la violence et la marginalisation.info:eu-repo/semantics/publishe

A arte de resistir : da prática teatral à luta pelo reconhecimento nas favelas do Rio de Janeiro

Face aux différentes formes de violences et de stigmatisation présentes dans les favelas de Rio de Janeiro, de nouveaux modes de résistance s’organisent. Les formes classiques de mobilisations populaires se voient bousculées par des mouvements de contestation qui prennent appui sur de nouveaux outils de résistance. La pratique artistique et en particulier le théâtre jouent un rôle important dans ce domaine, en créant des espaces de dialogue, de transmission et de conscientisation. À partir de données empiriques récoltées durant une enquête de terrain de six mois dans le complexe de favelas de la Maré à Rio de Janeiro, notre travail propose de comprendre comment la pratique du Théâtre de l’Opprimé peut mener les actrices et acteurs favelados à entrer dans une lutte pour la reconnaissance de leurs droits. En s’appuyant sur un cadre théorique articulé autour de la théorie de la lutte pour la reconnaissance, cette recherche appréhende le rapport entre art, politisation et engagement militant, dans un espace marqué par la violence et la marginalisation.info:eu-repo/semantics/publishe

Plasma cell-directed therapies in monoclonal gammopathy-associated scleromyxedema.

International audienceScleromyxedema is a rare skin and systemic mucinosis that is usually associated with monoclonal gammopathy (MG). In this French, multicenter, retrospective study of 33 patients, we investigated the clinical and therapeutic features of MG-associated scleromyxedema. Skin molecular signatures were analyzed using a transcriptomic approach. Skin symptoms included papular eruptions (100%), sclerodermoid features (91%), and leonine facies (39%). MG involved an IgG isotype in all patients, with a predominant λ light chain (73%). Associated hematologic malignancies were diagnosed in 4/33 patients (12%) (smoldering myeloma, n=2; chronic lymphoid leukemia, n=1; and refractory cytopenia with multilineage dysplasia n=1). Carpal tunnel syndrome (33%), arthralgia (25%) and dermato-neuro syndrome (DNS) (18%) were the most common systemic complications. One patient with mucinous cardiopathy died of acute heart failure. Intravenous immunoglobulin (HDIVig) treatment alone or in combination with steroids appeared to be quite effective in nonsevere cases (clinical complete response achieved in 13/31 patients). Plasma cell-directed therapies using lenalidomide and/or bortezomib with dexamethasone and HDIVig led to a significant improvement in severe cases (HDIVig-refractory or cases with central nervous system or cardiac involvement). The emergency treatment of DNS with combined plasmapheresis, HDIVig, and high-dose corticosteroids induced the complete remission of neurological symptoms in 4/5 patients. Quantitative reverse transcriptase-PCR (RT-PCR) analysis of 6 scleromyxedema skin samples showed significantly higher profibrotic pathway levels (transforming growth factor β (TGFβ) and collagen-1) than in healthy skin. Prospective studies targeting plasma cell clones and/or fibrotic pathways are warranted for long-term scleromyxedema management

Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington’s Disease Mice

In hereditary neurodegenerative Huntington's disease (HD), there exists a growing consideration that sleep and circadian dysregulations may be important symptoms. It is not known, however, whether sleep abnormalities contribute to other behavioral deficits in HD patients and mouse models. To determine the precise chronology for sleep physiology alterations and other sensory, motor, psychiatric and cognitive symptoms of HD, the same R6/1 HD transgenics and their wild-type littermates were recorded monthly for sleep electroencephalogram (EEG) together with a wide range of behavioral tests according to a longitudinal plan. We found an early and progressive deterioration of both sleep architecture and EEG brain rhythms in R6/1 mice, which are correlated timely with their spatial working memory impairments. Sleep fragmentation and memory impairments were accompanied by the loss of delta (1-4 Hz) power in the transgenic mice, the magnitude of which increased with age and disease progression. These precocious sleep and cognitive impairments were followed by deficits in social behavior, sensory and motor abilities. Our data confirm the existence and importance of sleep physiology alterations in the widely used R6/1 mouse line and highlight their precedence over other plethoric phenotypic changes. The brainwave abnormalities, may represent a novel biomarker and point to innovative therapeutic interventions against HD

Search for Scalar Diphoton Resonances in the Mass Range 65−60065-600 GeV with the ATLAS Detector in pppp Collision Data at s\sqrt{s} = 8 TeVTeV

A search for scalar particles decaying via narrow resonances into two photons in the mass range 65–600 GeV is performed using $20.3\text{}\text{}{\mathrm{fb}}^{-1}$ of $\sqrt{s}=8\text{}\text{}\mathrm{TeV}$ $pp$ collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits at the 95% confidence level on the production cross section of a scalar boson times branching ratio into two photons, in a fiducial volume where the reconstruction efficiency is approximately independent of the event topology. The upper limits set extend over a considerably wider mass range than previous searches