The treatment of Parkinson's disease using MAO-B inhibitors

Monoamine Oxidase Inhibitors have sparked great controversy in the treatment of idiopathic Parkinson’s Disease. There is little doubt that Monoamine Oxidase Inhibitors work synergistically with Levodopa to reduce several major debilitating symptoms. Multiple other medications provide a similar symptomatic benefit when combined with Levodopa; thus, a symptomatic benefit alone does little to advance current Parkinson’s treatment. The great controversy in treatment then comes from the possibility that Monoamine Oxidase Inhibitors modify the natural course of Parkinson’s Disease. This class of drug protected nigrostriatal dopaminergic neurons in many cellular and animal studies. Clinical studies involving Monoamine Oxidase Inhibitors are more controversial. Several studies have shown results that suggest a neuroprotective effect while other have not. This may be because the tools used to assess PD progression are inadequate. To see a clear decrease in nigrostriatal dopaminergic death, and thus prove a neuroprotective effect, more advanced techniques to measure the progression of Parkinson’s Disease must be developed. Given the controversy it will be important to revisit the benefits of MAO-B inhibitors once more advanced progression techniques are available

Fatal Acute Cellulitis Due to Neisseria meningitidis

We describe the first fatal evolution of cellulitis due to Neisseria meningitidis serogroup Y involving an 85-year-old woman. She presented with an extensive cellulitis of the left side of the face, neck, and thorax and septic shock. In spite of active antibiotic therapy, evolution was rapidly fatal

Diverses demandes de congés, lors de la séance du 8 octobre 1790

Roux de Raze Charles François, Châtelet Louis-Marie du, Arnoult Charles André, Lepoutre Pierre-François. Diverses demandes de congés, lors de la séance du 8 octobre 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XIX - Du 16 septembre au 23 octobre 1790. Paris : Librairie Administrative P. Dupont, 1884. p. 510

Diverses demandes de congés, lors de la séance du 8 octobre 1790

de Raze, Châtelet Louis-Marie du, Arnoult Charles André, Lepoutre Pierre François. Diverses demandes de congés, lors de la séance du 8 octobre 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XIX - Du 16 septembre au 23 octobre 1790. Paris : Librairie Administrative P. Dupont, 1884. p. 510

Faust

De cada obra s'ha digitalitzat un programa sencer. De la resta s'han digitalitzat les parts que són diferents.Direcció artística Empresa Juan Mestres CalvetEmpresa: Juan Mestres Calve

Manon

De cada obra s'ha digitalitzat un programa sencer. De la resta s'han digitalitzat les parts que són diferents.Direcció artística Empresa Juan Mestres CalvetEmpresa: Juan Mestres CalvetÒpera de Jules Massene

Subretinal drusenoid deposits in an elderly population with age-related macular degeneration (MONTRACHET study: Maculopathy, Optic Nerve, nuTRition, neurovasCular and HEarT diseases)

National audiencePurpose To determine the frequency of subretinal drusenoid deposits (SDD) in a French population of elderly patients presenting an age‐related macular degeneration (AMD) in the MONTRACHET study. Methods The three‐city study (3C) was a population‐based study including 9294 patients older than 65 years from three French cities (Dijon, Bordeaux and Montpellier) at baseline in 1999. After 10 years, the cohort of Dijon benefited from a complete ophthalmologic examination as part of the MONTRACHET study. Each patient underwent a non‐mydriatic retinophotography associated with a spectral‐domain OCT examination (SD‐OCT) of the macula. AMD classification was established according to the classification of the Multi‐Ethnic study of Atherosclerosis (MESA) for the retinophotography analysis and with the E3 CONSORTIUM classification for the SD‐OCT analysis. Patients with uninterpretable images of both eyes were excluded from statistical analysis. Results One thousand one hundred fifty three subjects were included. 62.7% were female and the mean age was 82.2 ± 3.8 years. With retinophotography analysis, the frequency of SDD was 1.9% (n = 38 eyes). With the SD‐OCT macular analysis, the frequency of SDD was 14.8% (n = 342). In patients presenting with SDD, 68.8% (n = 137) had a bilateral involvement. The relative risk (RR) of presenting SDD lesions in patients older than 80 years old was 2.6 (p < 0.001) and in women at 1.3 (p < 0.045). An interruption of the ellipsoide line and an alteration of the retinal pigment epithelium were statistically associated with the presence of SDD: RR = 5.9 (p < 0.001) and RR = 2.8 (p < 0.001), respectively. The average thickness of the subfoveal choroid was thinner in subjects presenting SDD (174.9 μm with SDD vs 209.8 μm without SDD, p < 0.001). Conclusions Few population‐based studies have established the frequency of SDD in an elderly population

Discussion du décret relatif à l’équipement des gardes nationales, lors de la séance du 4 septembre 1791

Prieur de la Marne Pierre Louis, Chabroud Charles, Arnoult Charles André, Huot de Goncourt Jean Antoine, Regnaud de Saint-Jean d'Angély Michel Louis Etienne, André Antoine Balthazar d'. Discussion du décret relatif à l’équipement des gardes nationales, lors de la séance du 4 septembre 1791. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XXX - Du 28 août au 17 septembre 1791. Paris : Librairie Administrative P. Dupont, 1888. pp. 192-193

Discussion au sujet d'une demande des citoyens de Dijon concernant la création d'une cour de justice, lors de la séance du 21 juin 1790

Martineau Louis-Simon, Populus Marc Etienne, Defermon des Chapelières Jacques, Arnoult Charles André, Brillat-Savarin Jean Anthelme, André Antoine Balthazar d', Mougins de Roquefort Jean Joseph. Discussion au sujet d'une demande des citoyens de Dijon concernant la création d'une cour de justice, lors de la séance du 21 juin 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XVI - Du 31 mai au 8 juillet 1790. Paris : Librairie Administrative P. Dupont, 1883. pp. 395-396