3,406 research outputs found
RINGO3: a multi-colour fast response polarimeter
GRB jets contain rapidly moving electrons which will spiral around magnetic field lines. This causes them to emit polarized synchrotron emission. We have built a series of polarimeters (RINGO and RINGO2) to investigate this by measuring the polarization of optical light from GRBs at a certain single wavelength. The instruments are mounted on the Liverpool Telescope, which is a fully robotic (i.e. unmanned) telescope on La Palma which reacts to triggers from satellites such as the NASA SWIFT mission. This has had great success, with the first ever detections of early time optical polarization being made. In addition, the first measurements of the change in optical polarization from a GRB as the jet expands have recently been obtained. In this paper we describe the design and construction of RINGO3. This will be a multi-colour instrument that can observe simultaneously at three wavelengths. By doing so we will be able to unambiguously identify where in the burst the polarized emission is coming from. This will allow us to distinguish between three possibilities: (1) Magnetic instabilities generated in the shock front, (2) Line of sight effects and (3) Large-scale magnetic fields present throughout the relativistic outflow. The instrument design combines a rapidly rotating polaroid, specially designed polarization insensitive dichroic mirrors and three electron multiplying CCD cameras to provide simultaneous wavelength coverage with a time resolution of 1 second
Selective Metal Cation Capture by Soft Anionic Metal-Organic Frameworks via Drastic Single-Crystal-to-Single-Crystal Transformations
In this paper we describe a novel framework for the discovery of the topical
content of a data corpus, and the tracking of its complex structural changes
across the temporal dimension. In contrast to previous work our model does not
impose a prior on the rate at which documents are added to the corpus nor does
it adopt the Markovian assumption which overly restricts the type of changes
that the model can capture. Our key technical contribution is a framework based
on (i) discretization of time into epochs, (ii) epoch-wise topic discovery
using a hierarchical Dirichlet process-based model, and (iii) a temporal
similarity graph which allows for the modelling of complex topic changes:
emergence and disappearance, evolution, and splitting and merging. The power of
the proposed framework is demonstrated on the medical literature corpus
concerned with the autism spectrum disorder (ASD) - an increasingly important
research subject of significant social and healthcare importance. In addition
to the collected ASD literature corpus which we will make freely available, our
contributions also include two free online tools we built as aids to ASD
researchers. These can be used for semantically meaningful navigation and
searching, as well as knowledge discovery from this large and rapidly growing
corpus of literature.Comment: In Proc. Pacific-Asia Conference on Knowledge Discovery and Data
Mining (PAKDD), 201
Plasma photoemission from string theory
Leading 't Hooft coupling corrections to the photoemission rate of the planar
limit of a strongly-coupled {\cal {N}}=4 SYM plasma are investigated using the
gauge/string duality. We consider the full order \alpha'^3 type IIB string
theory corrections to the supergravity action, including higher order terms
with the Ramond-Ramond five-form field strength. We extend our previous results
presented in arXiv:1110.0526. Photoemission rates depend on the 't Hooft
coupling, and their curves suggest an interpolating behaviour from strong
towards weak coupling regimes. Their slopes at zero light-like momentum give
the electrical conductivity as a function of the 't Hooft coupling, in full
agreement with our previous results of arXiv:1108.6306. Furthermore, we also
study the effect of corrections beyond the large N limit.Comment: 36 pages, 5 figures, paragraph added in the conclusions, references
added, typos correcte
Buttressing staples with cholecyst-derived extracellular matrix (CEM) reinforces staple lines in an ex vivo peristaltic inflation model
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008Background - Staple line leakage and bleeding are the most common problems associated with the use of surgical staplers for gastrointestinal resection and anastomotic procedures. These complications can be reduced by reinforcing the staple lines with buttressing materials. The current study reports the potential use of cholecyst-derived extracellular matrix (CEM) in non-crosslinked (NCEM) and crosslinked (XCEM) forms, and compares their mechanical performance with clinically available buttress materials [small intestinal submucosa (SIS) and bovine pericardium (BP)] in an ex vivo small intestine model.
Methods - Three crosslinked CEM variants (XCEM0005, XCEM001, and XCEM0033) with different degree of crosslinking were produced. An ex vivo peristaltic inflation model was established. Porcine small intestine segments were stapled on one end, using buttressed or non-buttressed surgical staplers. The opened, non-stapled ends were connected to a peristaltic pump and pressure transducer and sealed. The staple lines were then exposed to increased intraluminal pressure in a peristaltic manner. Both the leak and burst pressures of the test specimens were recorded.
Results - The leak pressures observed for non-crosslinked NCEM (137.8 ± 22.3 mmHg), crosslinked XCEM0005 (109.1 ± 14.1 mmHg), XCEM001 (150.1 ± 16.0 mmHg), XCEM0033 (98.8 ± 10.5 mmHg) reinforced staple lines were significantly higher when compared to non-buttressed control (28.3 ± 10.8 mmHg) and SIS (one and four layers) (62.6 ± 11.8 and 57.6 ± 12.3 mmHg, respectively) buttressed staple lines. NCEM and XCEM were comparable to that observed for BP buttressed staple lines (138.8 ± 3.6 mmHg). Only specimens with reinforced staple lines were able to achieve high intraluminal pressures (ruptured at the intestinal mesentery), indicating that buttress reinforcements were able to withstand pressure higher than that of natural tissue (physiological failure).
Conclusions - These findings suggest that the use of CEM and XCEM as buttressing materials is associated with reinforced staple lines and increased leak pressures when compared to non-buttressed staple lines. CEM and XCEM were found to perform comparably with clinically available buttress materials in this ex vivo model.Enterprise Irelan
Higgs and Dark Matter Hints of an Oasis in the Desert
Recent LHC results suggest a standard model (SM)-like Higgs boson in the
vicinity of 125 GeV with no clear indications yet of physics beyond the SM. At
the same time, the SM is incomplete, since additional dynamics are required to
accommodate cosmological dark matter (DM). In this paper we show that
interactions between weak scale DM and the Higgs which are strong enough to
yield a thermal relic abundance consistent with observation can easily
destabilize the electroweak vacuum or drive the theory into a non-perturbative
regime at a low scale. As a consequence, new physics--beyond the DM
itself--must enter at a cutoff well below the Planck scale and in some cases as
low as O(10 - 1000 TeV), a range relevant to indirect probes of flavor and CP
violation. In addition, this cutoff is correlated with the DM mass and
scattering cross-section in a parameter space which will be probed
experimentally in the near term. Specifically, we consider the SM plus
additional spin 0 or 1/2 states with singlet, triplet, or doublet electroweak
quantum numbers and quartic or Yukawa couplings to the Higgs boson. We derive
explicit expressions for the full two-loop RGEs and one-loop threshold
corrections for these theories.Comment: 29 pages, 13 figure
Network analysis of team communication in a busy emergency department
Background: The Emergency Department (ED) is consistently described as a high-risk environment for patients and clinicians that demands colleagues quickly work together as a cohesive group. Communication between nurses, physicians, and other ED clinicians is complex and difficult to track. A clear understanding of communications in the ED is lacking, which has a potentially negative impact on the design and effectiveness of interventions to improve communications. We sought to use Social Network Analysis (SNA) to characterize communication between clinicians in the ED. Methods. Over three-months, we surveyed to solicit the communication relationships between clinicians at one urban academic ED across all shifts. We abstracted survey responses into matrices, calculated three standard SNA measures (network density, network centralization, and in-degree centrality), and presented findings stratified by night/day shift and over time. Results: We received surveys from 82% of eligible participants and identified wide variation in the magnitude of communication cohesion (density) and concentration of communication between clinicians (centralization) by day/night shift and over time. We also identified variation in in-degree centrality (a measure of power/influence) by day/night shift and over time. Conclusions: We show that SNA measurement techniques provide a comprehensive view of ED communication patterns. Our use of SNA revealed that frequency of communication as a measure of interdependencies between ED clinicians varies by day/night shift and over time. © 2013 Patterson et al.; licensee BioMed Central Ltd
Prehistory of Transit Searches
Nowadays the more powerful method to detect extrasolar planets is the transit
method. We review the planet transits which were anticipated, searched, and the
first ones which were observed all through history. Indeed transits of planets
in front of their star were first investigated and studied in the solar system.
The first observations of sunspots were sometimes mistaken for transits of
unknown planets. The first scientific observation and study of a transit in the
solar system was the observation of Mercury transit by Pierre Gassendi in 1631.
Because observations of Venus transits could give a way to determine the
distance Sun-Earth, transits of Venus were overwhelmingly observed. Some
objects which actually do not exist were searched by their hypothetical
transits on the Sun, as some examples a Venus satellite and an infra-mercurial
planet. We evoke the possibly first use of the hypothesis of an exoplanet
transit to explain some periodic variations of the luminosity of a star, namely
the star Algol, during the eighteen century. Then we review the predictions of
detection of exoplanets by their transits, those predictions being sometimes
ancient, and made by astronomers as well as popular science writers. However,
these very interesting predictions were never published in peer-reviewed
journals specialized in astronomical discoveries and results. A possible
transit of the planet beta Pic b was observed in 1981. Shall we see another
transit expected for the same planet during 2018? Today, some studies of
transits which are connected to hypothetical extraterrestrial civilisations are
published in astronomical refereed journals. Some studies which would be
classified not long ago as science fiction are now considered as scientific
ones.Comment: Submiited to Handbook of Exoplanets (Springer
Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens, compounds with estrogenic metabolites, estrogenic antagonists, and a known cytotoxic agent. Also included in the test panel were 17β-estradiol as a positive control and ethanol as solvent control. The test compounds were coded before distribution. Test methods included direct binding to the estrogen receptor (ER), proliferation of MCF-7 cells, transient reporter gene expression in MCF-7 cells, reporter gene expression in yeast strains stably transfected with the human ER and an estrogen-responsive reporter gene, and vitellogenin production in juvenile rainbow trout. 17β-Estradiol, 17α-ethynyl estradiol, and diethylstilbestrol induced a strong estrogenic response in all test systems. Colchicine caused cytotoxicity only. Bisphenol A induced an estrogenic response in all assays. The results obtained for the remaining test compounds—tamoxifen, ICI 182.780, testosterone, bisphenol A dimethacrylate, 4-n-octylphenol, 4-n-nonylphenol, nonylphenol dodecylethoxylate, butylbenzylphthalate, dibutylphthalate, methoxychlor, o,p′-DDT, p,p′-DDE, endosulfan, chlomequat chloride, and ethanol—varied among the assays. The results demonstrate that careful standardization is necessary to obtain a reasonable degree of reproducibility. Also, similar methods vary in their sensitivity to estrogenic compounds. Thus, short-term tests are useful for screening purposes, but the methods must be further validated by additional interlaboratory and interassay comparisons to document the reliability of the methods
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