Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer

Objectives. Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1α) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology. Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results. Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1α and VEGF-A (P=0.016). Patients with overexpression of HIF-1α had a tendency to better survival with marginal statistical significance (P=0.062). Patients with overexpression of VEGF-A had worse survival, but not statistically significant (P=0.133). Conclusion. The present study revealed that VEGF-A showed correlation with HIF-1α. HIF-1α had a tendency to protective effect with a P value close to statistical significance. VEGF-A showed a contrary effect but without statistical significance

Mediastinitis necrosante descendente: tratamiento con drenaje torácico transcervical

Presentamos el caso clínico de un varón de 29 años de edad que presentó una mediastinitis necrosante descendente con extensión infracarinal secundaria a un proceso infeccioso orofaríngeo. La infección torácica fue tratada mediante un drenaje torácico vía transcervical, que se retiró al decimoquinto día del postoperatorio. La evolución fue favorable sin necesidad de una reintervención más radical. Consideramos que en la mediastinitis necrosante descendente con extensión infracarinal sin rotura pleural es útil inicialmente el tratamiento con drenaje torácico transcervical