El espacio y el tiempo

Preguntas sobre el espacio y el tiempo inquietan los pensamientos del hombre desde hace miles de años. ¿Qué es el espacio? ¿Qué es el tiempo? ¿Vale la pena responder estas preguntas? Presento en este artículo las posturas de algunos pensadores, y mi posición al respecto, con el fin de destacar la importancia de esta área de la Filosofía

First results of the glitching pulsars monitoring program at the Argentine Institute of Radioastronomy

We report here on the first results of a systematic monitoring of southern glitching pulsars at the Argentine Institute of Radio astronomy started on the year 2019. We detected a major glitch in the Vela pulsar (PSR J0835$-$4510) and two mini-glitches in PSR J1048$-$5832. For each glitch, we present the measurement of glitch parameters by fitting timing residuals. We then make an individual pulses study of Vela in observations previous and after the glitch. We selected 6 days of observations around the major glitch on July 22nd 2021 and study their statistical properties with machine learning techniques. We use Variational AutoEncoder (VAE) reconstruction of the pulses to separate them clearly from the noise. We perform a study with Self-Organizing Maps (SOM) clustering techniques and find an unusual behavior of the clusters two days prior to the glitch. This behavior is only visible in the the higher amplitude pulse clusters and if intrinsic to the pulsar could be interpreted as a precursor of the glitch.Comment: 13 pages, 13 figures, 13 table

Electromagnetic signatures from supermassive binary black holes approaching merger

We present fully relativistic predictions for the electromagnetic emission produced by accretion disks surrounding spinning and nonspinning supermassive binary black holes on the verge of merging. We use the code bothros to post-process data from 3D General Relativistic Magnetohydrodynamic (GRMHD) simulations via ray-tracing calculations. These simulations model the dynamics of a circumbinary disk and the mini-disks that form around two equal-mass black holes orbiting each other at an initial separation of 20 gravitational radii, and evolve the system for more than 10 orbits in the inspiral regime. We model the emission as the sum of thermal blackbody radiation emitted by an optically thick accretion disk and a power-law spectrum extending to hard X-rays emitted by a hot optically thin corona. We generate time-dependent spectra, images, and light curves at various frequencies to investigate intrinsic periodic signals in the emission, as well as the effects of the black hole spin. We find that prograde black hole spin makes mini-disks brighter since the smaller ISCO angular momentum demands more dissipation before matter plunges to the horizon. However, compared to mini-disks in larger separation binaries with spinning black holes, our mini-disks are less luminous: unlike those systems, their mass accretion rate is lower than in the circumbinary disk, and they radiate with lower efficiency because their inflow times are shorter. Compared to a single black hole system matched in mass and accretion rate, these binaries have spectra noticeably weaker and softer in the UV. Finally, we discuss the implications of our findings for the potential observability of these systems.Comment: 21 pages, 15 figures, accepted for publication in Ap

Odanacatib for the treatment of postmenopausal osteoporosis : Results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Background Odanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone mineral density in postmenopausal women with low bone mass. We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. Methods The Long-term Odanacatib Fracture Trial (LOFT) was a multicentre, randomised, double-blind, placebo-controlled, event-driven study at 388 outpatient clinics in 40 countries. Eligible participants were women aged at least 65 years who were postmenopausal for 5 years or more, with a femoral neck or total hip bone mineral density T-score between −2·5 and −4·0 if no previous radiographic vertebral fracture, or between −1·5 and −4·0 with a previous vertebral fracture. Women with a previous hip fracture, more than one vertebral fracture, or a T-score of less than −4·0 at the total hip or femoral neck were not eligible unless they were unable or unwilling to use approved osteoporosis treatment. Participants were randomly assigned (1:1) to either oral odanacatib (50 mg once per week) or matching placebo. Randomisation was done using an interactive voice recognition system after stratification for previous radiographic vertebral fracture, and treatment was masked to study participants, investigators and their staff, and sponsor personnel. If the study completed before 5 years of double-blind treatment, consenting participants could enrol in a double-blind extension study (LOFT Extension), continuing their original treatment assignment for up to 5 years from randomisation. Primary endpoints were incidence of vertebral fractures as assessed using radiographs collected at baseline, 6 and 12 months, yearly, and at final study visit in participants for whom evaluable radiograph images were available at baseline and at least one other timepoint, and hip and non-vertebral fractures adjudicated as being a result of osteoporosis as assessed by clinical history and radiograph. Safety was assessed in participants who received at least one dose of study drug. The adjudicated cardiovascular safety endpoints were a composite of cardiovascular death, myocardial infarction, or stroke, and new-onset atrial fibrillation or flutter. Individual cardiovascular endpoints and death were also assessed. LOFT and LOFT Extension are registered with ClinicalTrials.gov (number NCT00529373) and the European Clinical Trials Database (EudraCT number 2007-002693-66). Findings Between Sept 14, 2007, and Nov 17, 2009, we randomly assigned 16 071 evaluable patients to treatment: 8043 to odanacatib and 8028 to placebo. After a median follow-up of 36·5 months (IQR 34·43–40·15) 4297 women assigned to odanacatib and 3960 assigned to placebo enrolled in LOFT Extension (total median follow-up 47·6 months, IQR 35·45–60·06). In LOFT, cumulative incidence of primary outcomes for odanacatib versus placebo were: radiographic vertebral fractures 3·7% (251/6770) versus 7·8% (542/6910), hazard ratio (HR) 0·46, 95% CI 0·40–0·53; hip fractures 0·8% (65/8043) versus 1·6% (125/8028), 0·53, 0·39–0·71; non-vertebral fractures 5·1% (412/8043) versus 6·7% (541/8028), 0·77, 0·68–0·87; all p<0·0001. Combined results from LOFT plus LOFT Extension for cumulative incidence of primary outcomes for odanacatib versus placebo were: radiographic vertebral fractures 4·9% (341/6909) versus 9·6% (675/7011), HR 0·48, 95% CI 0·42–0·55; hip fractures 1·1% (86/8043) versus 2·0% (162/8028), 0·52, 0·40–0·67; non-vertebral fractures 6·4% (512/8043) versus 8·4% (675/8028), 0·74, 0·66–0·83; all p<0·0001. In LOFT, the composite cardiovascular endpoint of cardiovascular death, myocardial infarction, or stroke occurred in 273 (3·4%) of 8043 patients in the odanacatib group versus 245 (3·1%) of 8028 in the placebo group (HR 1·12, 95% CI 0·95–1·34; p=0·18). New-onset atrial fibrillation or flutter occurred in 112 (1·4%) of 8043 patients in the odanacatib group versus 96 (1·2%) of 8028 in the placebo group (HR 1·18, 0·90–1·55; p=0·24). Odanacatib was associated with an increased risk of stroke (1·7% [136/8043] vs 1·3% [104/8028], HR 1·32, 1·02–1·70; p=0·034), but not myocardial infarction (0·7% [60/8043] vs 0·9% [74/8028], HR 0·82, 0·58–1·15; p=0·26). The HR for all-cause mortality was 1·13 (5·0% [401/8043] vs 4·4% [356/8028], 0·98–1·30; p=0·10). When data from LOFT Extension were included, the composite of cardiovascular death, myocardial infarction, or stroke occurred in significantly more patients in the odanacatib group than in the placebo group (401 [5·0%] of 8043 vs 343 [4·3%] of 8028, HR 1·17, 1·02–1·36; p=0·029, as did stroke (2·3% [187/8043] vs 1·7% [137/8028], HR 1·37, 1·10–1·71; p=0·0051). Interpretation Odanacatib reduced the risk of fracture, but was associated with an increased risk of cardiovascular events, specifically stroke, in postmenopausal women with osteoporosis. Based on the overall balance between benefit and risk, the study's sponsor decided that they would no longer pursue development of odanacatib for treatment of osteoporosis