3 research outputs found
Automated ICF Coding of Rehabilitation Notes for Low-Resource Languages via Continual Training of Language Models
- Author
- Publication venue
- Publication date
- 01/01/2023
- Field of study
: The coding of medical documents and in particular of rehabilitation notes using the International Classification of Functioning, Disability and Health (ICF) is a difficult task showing low agreement among experts. Such difficulty is mainly caused by the specific terminology that needs to be used for the task. In this paper, we address the task developing a model based on a large language model, BERT. By leveraging continual training of such a model using ICF textual descriptions, we are able to effectively encode rehabilitation notes expressed in Italian, an under-resourced language
Effects of preâoperative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Accarino Giancarlo
- Adolfo Renzi
- Adriana Cordova
- Akihiro Kanaya
- Akira Kuriyama
- Alberto Abrate
- Alberto Aiolfi
- Alberto Biondi
- Alberto Brolese
- Alberto Macchi
- Alberto Porcu
- Alberto Tonelli
- Alberto Zangrillo
- Aldo Vagge
- Alessandra Murgese
- Alessandra Novi
- Alessandra Pecoraro
- Alessandra Zullo
- Alessandro Broglia
- Alessandro Fancellu
- Alessandro Ferdinando Ruffolo
- Alessandro Fiorini
- Alessandro Fogliati
- Alessandro Frati
- Alessandro Galdini
- Alessandro Giani
- Alessandro Giardino
- Alessandro Grandi
- Alessandro Grechi
- Alessandro Gronchi
- Alessandro Iacomino
- Alessandro Longhini
- Alessandro Michele Bonomi
- Alessandro Spolini
- Alessandro Strumia
- Alessandro Tedde
- Alessandro Zerbi
- Alessia Aversano
- Alessio Palumbo
- Alexandre Anesi
- Alfio Spina
- Alfonso Manfuso
- Alfredo Annicchiarico
- Alfredo Guglielmi
- Alice Frontali
- Andrea Bartalini Cinughi de Pazzi
- Andrea Belli
- Andrea Bondurri
- Andrea Caravati
- Andrea Casaril
- Andrea Costantino
- Andrea Costanzi
- Andrea de Manzoni Garberini
- Andrea Gattolin
- Andrea Leva
- Andrea Locatelli
- Andrea Lovece
- Andrea Melloni
- Andrea Mingoli
- Andrea Morandi
- Andrea Mulliri
- Andrea Muratore
- Andrea Picchetto
- Andrea Rizzi
- Andrea Ruzzenente
- Andrea Sagnotta
- Andrea Sozzi
- Andrea Tubaro
- Andrea Tufo
- Andrea Varazzani
- Andrea Vignali
- Angelica Rizzoli
- Angelino Sanna
- Angelo Airoldi
- Angelo Alessandro Marra
- Angelo Gabriele Epifani
- Angelo Parello
- Anna Fornasari
- Anna Giacomina Carta
- Anna Lisa Pesce
- Anna Maffioli
- Anna Rita Tanca
- Annamaria Agnes
- Antonella Ardito
- Antonella Chessa
- Antonella Larcinese
- Antonella Polimeni
- Antonino Ditto
- Antonino Francesco Germano
- Antonio Bozzani
- Antonio Cappiello
- Antonio Castaldi
- Antonio Fratto
- Antonio Freyrie
- Antonio La Greca
- Antonio Mario Scanu
- Antonio Masciandaro
- Antonio Nicola Giordano
- Antonio Piras
- Antonio Santoro
- Arianna Casiraghi
- Ariberto Brivio
- Ario Takeuchi
- Armando De Virgilio
- Arrigo Pellacani
- Arturo Roncone
- Atsushi Sawada
- Barbara Binda
- Barbara Pichi
- Biagio Casagranda
- Biagio Zampogna
- Bonfanti Giulia
- Bottazzoli Elisa
- Bruno Cirillo
- Bruno Sensi
- Calogero Puma Pagliarello
- Camilla Cremonini
- Camillo Leonardo Bertoglio
- Carlo Castoro
- Carlo Corbellini
- Carlo Della Rocca
- Carlo Doria
- Carlo Maria Neri
- Carlo Ratto
- Carlo Traverso
- Carlotta De Cristofaro
- Carlotta La Raja
- Carlotta Zaborra
- Carmelo Mazzeo
- Carmine Antropoli
- Caterina Baldi
- Caterina Costanza Zingaretti
- Caterina Froiio
- Caterina Puccioni
- Cecilia Menna
- Celeste Del Basso
- Celestino Pio Lombardi
- Chiara Copelli
- Chiara Loffredo
- Chiara Marafante
- Chiara Vignotto
- Chikashi Takeda
- Chisaki Aze
- Claudia Casarini
- Claudio F Feo
- Claudio Guerci
- Claudio Iovino
- Colomba Frattaruolo
- Corrado Ciatti
- Corrado Pedrazzani
- Cosimo Callari
- Cosimo De Nunzio
- Cristian Altana
- Cristina Barberio
- Cristina Cerri
- Cristina Dell'Oro
- Cristoforo Fabbris
- Daisuke Hashimoto
- Daisuke Irimada
- Dalila Loredana Lo Bue
- Damiano Soma
- Daniela Canzonieri
- Daniela Rega
- Daniele Armellin
- Daniele Bernardi
- Daniele Bissacco
- Daniele Bugada
- Daniele Crocetti
- Daniele Fusario
- Daniele Matta
- Darienzo Antonio
- Dario Di Miceli
- Dario Tartaglia
- Davide Bona
- Davide Citterio
- Davide Drigo
- Davide Rizzo
- Davide Russo
- Denise Gambardella
- Diana Carpaneto
- Diego Ribuffo
- Diego Sasia
- Domenico Baccellieri
- Domenico D'Ugo
- Domenico Iovino
- Domenico Massullo
- Domenico Mirabella
- Domenico Rossi
- Domenico Soriero
- Edoardo Baldini
- Eiji Kashiwagi
- Eiki Kanemaru
- Elena Manzo
- Elena Marotta
- Elena Russo
- Elia Giuseppe Lunghi
- Elisa Cabrini
- Elisa Cassinotti
- Elisa Francone
- Elisa Galfrascoli
- Elisa Scarnecchia
- Elisa Sebastiani
- Elisabetta Moggia
- Elisabetta Travaglio
- Emanuele Cammarata
- Emanuele Luigi Giuseppe Asti
- Emanuele Picone
- Emi Takano
- Emma Amal Nahal
- Emma Zuppi
- Enrica Deiana
- Enrico Battistella
- Enrico Fiori
- Enrico Pinotti
- Enrico Ruffini
- Erica Mazzotta
- Erica Statuti
- Erika Andreatta
- Erino Angelo Rendina
- Ester Marra
- Ettore Dinoto
- Eugenio Cocozza
- Eugenio Cucinotta
- Fabio Ferreli
- Fabio Marino
- Fabio Martinelli
- Fabio Milia
- Fabrizio Lorusso
- Fabrizio Monaco
- Fabrizio Scognamillo
- Fausto Catena
- Fausto Rosa
- Federica Brunetti
- Federica Cipriani
- Federica Falaschi
- Federica Ferracci
- Federica Maffeis
- Federica Scolari
- Federico Coccolini
- Federico Cozzani
- Federico De Michele
- Federico Fusini
- Felice Eugenio Agro
- Felice Pecoraro
- Fernando Rosatti
- Filippo Carannante
- Filippo Gagliardi
- Filippo La Torre
- Flaminia Campo
- Flavia Ciccarone
- Flavio Milana
- Fotios Kalfas
- Francesca Ascari
- Francesca Bertolina
- Francesca Bunino
- Francesca Cavenago
- Francesca DalpraÌ
- Francesca De Felice
- Francesca De Lucia
- Francesca Farnesi
- Francesca Gaino
- Francesca Paola Tropeano
- Francesca Pecchini
- Francesca Pirola
- Francesca Ratti
- Francesca Simonelli
- Francesca Toia
- Francesco Antonio Ciarleglio
- Francesco Belia
- Francesco Bianco
- Francesco Bussu
- Francesco Chu
- Francesco Colombo
- Francesco Corcione
- Francesco de Falco
- Francesco Dessole
- Francesco Di Marzo
- Francesco Ferrara
- Francesco Fleres
- Francesco Guerrera
- Francesco Izzo
- Francesco Lemma
- Francesco Litta
- Francesco Maria Carrano
- Francesco Maria Romano
- Francesco Mastriale
- Francesco Mazzola
- Francesco Menegon Tasselli
- Francesco Pata
- Francesco Pisanu
- Francesco Porcelli
- Francesco Raspagliesi
- Francesco Selvaggi
- Francesco Volpin
- Franco Chioffi
- Franco Piredda
- Franco Ragni
- Franco Roviello
- Frigerio Isabella
- Fulvio Tagliabue
- Fumio Kinoshita
- Gabriele Bellio
- Gabriele Gecchele
- Gabriele Todaro
- Gabriele Tuderti
- Gabriella Teresa Capolupo
- Gaetano Lombardi
- Gaetano Luglio
- Gaia Altieri
- Gaia Colletti
- Gaia OldraÌ
- Gennaro Nappo
- Gennaro Perrone
- Georgios Peros
- Gerardo Caruso
- Gerardo Palmieri
- Gerardo Petruzzi
- Giacomo Benettini
- Giacomo Borroni
- Giacomo Crescentini
- Giacomo De Riu
- Giacomo Fiacchini
- Giacomo Pietrobon
- Giacomo Ruffo
- Giacomo Spinato
- Giacomo Zanus
- Giada Aizza
- Giampiero Capobianco
- Giancarlo D'ambrosio
- Gianfranco Meloni
- Gianluca Baronio
- Gianluca Franceschini
- Gianluca Matteo Sampietro
- Gianluca Nocera
- Gianluca Pagano
- Gianluigi Moretto
- Gianmarco Saponaro
- Gianmaria Casoni Pattacini
- Gianni Malossini
- Gianpaolo Marte
- Gilda Pepe
- Gioacchino Mattisi
- Gioia Brachini
- Giordana D'Aloisio
- Giorgio Badessi
- Giorgio Bogani
- Giorgio Candotti
- Giorgio Carlo Ginesu
- Giorgio De Toma
- Giorgio Lisi
- Giovanni Battista Fonsi
- Giovanni Butturini
- Giovanni Capretti
- Giovanni Cesana
- Giovanni Colombo
- Giovanni Domenico De Palma
- Giovanni Ferrari
- Giovanni Landoni
- Giovanni Marruzzo
- Giovanni Pesenti
- Giovanni Pirozzolo
- Giovanni Sinibaldi
- Giovanni Viel
- Giulia Bagaglini
- Giulia Bonavina
- Giulia Duranti
- Giulia Nezi
- Giulia Rossi
- Giulia Sedda
- Giulia Turri
- Giuliana Giuliani
- Giuliano Barugola
- Giulio Accarino
- Giulio Argenio
- Giulio Gasparini
- Giulio Santoro
- Giulio Sozzi
- Giuseppa Zancana
- Giuseppe Bianco
- Giuseppe Caristo
- Giuseppe Falco
- Giuseppe Ietto
- Giuseppe Mercante
- Giuseppe Pascarella
- Giuseppe Salamone
- Giuseppe Sica
- Giuseppe Simone
- Giuseppe Spriano
- Giuseppe Tisone
- Giuseppe Tropeano
- Grazia Travaglini
- Gregorio Di Franco
- Guglielmo Clarizia
- Guido Bissolotti
- Guido Coretti
- Guido Fiorentini
- Guido Sciaudone
- Harmony Impellizzeri
- Haruaki Hino
- Haruka Ishikawa
- Herald Nikaj
- Hidekazu Naganuma
- Hironori Tanaka
- Hiroshi Imai
- Hiroshi Okada
- Hiroshi Yonekura
- Hirotoshi Hasegawa
- Hiroyuki Inoue
- Hiroyuki Kitagawa
- Hisako Kubota
- Hishikawa Hidehiko
- Iacopo Dallan
- Ilaria Mattavelli
- Irene Tamanini
- Jacopo Graziosi
- Jacopo Matteucci
- Jacopo Zocchi
- Joel Reuben Abel
- Jun Makino
- Junichi Inokuchi
- Junichi Saito
- Kano Teruaki
- Katsuhiko Ishibashi
- Kazuhiko Yoshimatsu
- Kazuhiro Hanazaki
- Kazuyoshi Hirota
- Keikoku Tachibana
- Keisuke Monji
- Ken Lee
- Kenji Kawamura
- Kenji Shigemi
- Kentaroh Tarao
- Koji Iida
- Kota Kagawa
- Kouhei Nishikawa
- Kozo Sato
- Kyongsuk Son
- Lara Valentina Comini
- Laura Adamoli
- Laura Bardelli
- Laura Bernardi
- Laura Enrica Benedetti
- Laura Mariangela Castellano
- Laura Sala
- Leandro Siragusa
- Leo Licari
- Leo Licari
- Leonardo Teodonio
- Liliana Mereu
- Lodovica Cristofani Mencacci
- Lorena Di Girolami
- Lorenzo Aguzzoli
- Lorenzo Andreani
- Lorenzo Bosio
- Lorenzo Cobianchi
- Lorenzo Conti
- Lorenzo Giannini
- Lorenzo Livraghi
- Lorenzo Petagna
- Lorenzo Pignataro
- Lorenzo Scardina
- Lorenzo Spaggiari
- Luca Antonio Aldrighetti
- Luca Bellanti
- Luca Bertoglio
- Luca Bertolaccini
- Luca Bruschini
- Luca Campagnaro
- Luca Cardinali
- Luca Carlo Nespoli
- Luca Cigagna
- Luca Ferrario
- Luca Gordini
- Luca Malvezzi
- Luca Morelli
- Luca Muscatello
- Luca Resca
- Luca Sorrentino
- Lucia Paiano
- Lucio Selvaggi
- Lucrezia D'Alimonte
- Ludovica Baldari
- Ludovica Gibelli
- Luigi Angelo Vaira
- Luigi Beretta
- Luigi Bonavina
- Luigi Boni
- Luigi Conti
- Luigi Marano
- Luigi Marino Cosentino
- Luigi Rolli
- Luigi Simonelli
- Maini Marzia Isabella
- Makoto Ishitobi
- Manabu Kato
- Manfredo Tedesco
- Manuela Mastronardi
- Mara Franza
- Mara Palumbo
- Marcello CalabroÌ
- Marcello De Luca
- Marcello Giuseppe Spampinato
- Marcello Guaglio
- Marco Antonio Zappa
- Marco Assenza
- Marco Caricato
- Marco Cereda
- Marco Ceresoli
- Marco Chiarelli
- Marco Colasanti
- Marco De Zuanni
- Marco Domenichini
- Marco Fiore
- Marco Franzini
- Marco Giudice
- Marco Giuseppe Iannuccelli
- Marco Gramellini
- Marco Guido Confalonieri
- Marco Guzzo
- Marco Inama
- Marco Lotti
- Marco Lucchi
- Marco Maria Pascale
- Marco Massani
- Marco Migliore
- Marco Petrillo
- Marco Puccini
- Marco Rovagnati
- Marco Sparavigna
- Maria Benevolo
- Maria Caffo
- Maria Caputo
- Maria D'amico
- Maria Gabriella Dona
- Maria Laura Cossu
- Maria Michela Di Nuzzo
- Maria Paola Giusti
- Maria Paola Menna
- Mariano Catello Di Donna
- Marika Sharmayne Milani
- Marilena Marmiere
- Marina Bortul
- Mario Giuffrida
- Mario Guglielmo
- Mario Pannullo
- Mario Santinami
- Marta Bonaldi
- Marta Di Grezia
- Marta Tagliabue
- Martina Piloni
- Martina Zambon
- Marzia Franceschilli
- Masae Yamamoto
- Masaharu Higashida
- Masahiko Kawaguchi
- Masaki Shiota
- Masatoshi Eto
- Massimiliano Gennaro
- Massimiliano Pelli
- Massimiliano Tripoli
- Massimo Biondi
- Massimo Candiani
- Massimo Chiarugi
- Massimo Dugo
- Massimo Madonia
- Massimo Oldani
- Matilde Bacchion
- Matteo Cinquepalmi
- Matteo Desio
- Matteo Di Bari
- Matteo Filardo
- Matteo Marro
- Matteo Palma
- Matteo Palmeri
- Matteo Papandrea
- Matteo Rossini
- Matteo Tedde
- Matteo Uccelli Yasuyuki Fukami
- Matteo Vianini
- Mattia Berselli
- Mattia Di Bartolomeo
- Maurizio Cosimelli
- Maurizio Domanin
- Maurizio Ferrari
- Maurizio Romano
- Maurizio Salvati
- Mauro Casagrande
- Mauro Garino
- Mauro Montuori
- Mauro Rinaldi
- Mauro Zago
- Micaela Piccoli
- Michela Bergonzani
- Michela Campanelli
- Michela Monteleone
- Michele Achille Crespi
- Michele Cauteruccio
- Michele Grande
- Michele Malerba
- Michele Mazzola
- Michiaki Yamakage
- Miriana Picariello
- Mirko Pozzoni
- Mitsuru Ida
- Mizue Kamiyama
- Mohsen Ibrahim
- Mohssen Ansarin
- Motohiro Kikukawa
- Motonobu Kimizuka
- Munehiro Ogawa
- Naoki Hirai
- Naoyuki Hirata
- Nello Pirozzi
- NiccoloÌ Furbetta
- Nicola Guglielmo
- Nicoletta Sveva Pipitone Federico
- Nicolo Roffi
- NicoloÌ de Manzini
- NicoloÌ Tamini
- Nora Di Tomasso
- Noriaki Nishihara
- Norma Depalma
- Olindo Massarelli
- Oreste Iocca
- Osvaldo Carpineto Samorani
- Paola CampenniÌ
- Paola Cellerino
- Paola De Nardi
- Paola Germani
- Paola Incollingo
- Paolo Baroffio
- Paolo Bellora
- Paolo Boscolo Rizzo
- Paolo De Martini
- Paolo Del Rio
- Paolo Delrio
- Paolo Ivo Cavoretto
- Paolo Marchesi
- Paolo Sapienza
- Paolo Ubiali
- Pasquale Di Maio
- Pier Luigi Filosso
- Pierfrancesco Cadenelli
- Pierfrancesco Lapolla
- Pierfrancesco Pugliese
- Pierfranco Maria Cicerchia
- Piergiorgio Danelli
- Pierluigi Giumelli
- Pierpaolo Bordoni
- Pierpaolo Sileri
- Pietrina Cottu
- Pietro Ciccarino
- Pietro Familiari
- Pietro Fransvea
- Pietro Maida
- Pietro Maniscalco
- Pietro Maria Lombardi
- Pietro Mortini
- Placido Bruzzaniti
- Raffaele Galleano
- Raul Pellini
- Reina Okada
- Renato Patrone
- Renato Salvador
- Riccardo Balestri
- Riccardo Lenzi
- Riccardo Mastroianni
- Riccardo Rosati
- Rita De Berardinis
- Robert Fruscio
- Roberta Angelico
- Roberta Tutino
- Roberto Berretta
- Roberto Chiesa
- Roberto Colasanti
- Roberto Luca Meniconi
- Roberto Mancino
- Roberto Peltrini
- Roberto Persiani
- Roberto Pirrello
- Roberto Rimonda
- Roberto Salvia
- Roberto Salvioni
- Roberto Santambrogio
- Rocco Monica
- Rocco Papalia
- Romeo Patini
- Rosario Cennamo
- Ruggero Lionetti
- Sabatino D'Archi
- Sabine Cenciarelli
- Salomone Di Saverio
- Salvatora Dettori
- Salvatore Agnes
- Salvatore Dessole
- Salvatore Marano
- Salvatore Paiella
- Samuele Grandi
- Sandro Ciccarello
- Santi Trimarchi
- Saori Takatsuki
- Saori Tanaka
- Sara Cortinovis
- Sara Ornaghi
- Sara Tamburello
- Sara Torretta
- Sato Satoshi
- Satoshi Kazuma
- Satoshi Kobayashi
- Saverio Coiro
- Saverio Tateo
- Selene Bogoni
- Serena Gattoni
- Serena Musetti
- Serena Rossi
- Sergio Alfieri
- Sergio Gentilli
- Settimio Rossi
- Shingo Ito
- Shinichiro Okada
- Shinju Obara
- Shinnosuke Ohama
- Shintaro Yagi
- Sho Kumita
- Shosaburo Jotaki
- Shuichiro Neshige
- Shuko Matsuda
- Shunji Endo
- Shunsuke Tachibana
- Silvia Basato
- Silvia De Santi
- Silvia Fiorelli
- Silvia Moretto
- Silvia Palmisano
- Silvia Segattini
- Simona Gili
- Simona Meneghini
- Simone Colangeli
- Simone Conci
- Simone D'Annunzio
- Simone Mele
- Simone Novello
- Simone Rattizzato
- Simonetta Massaron
- Sofia Campanella
- Sofia Di Lorenzo
- Sofia Usai
- Sokol Trungu
- Stefania Angela Piccioni
- Stefania La Rocca
- Stefano Berrettini
- Stefano Bonomi
- Stefano D'Ugo
- Stefano Fresilli
- Stefano Fusetti
- Stefano Lazzari
- Stefano Maria Massimiliano Basso
- Stefano Megna
- Stefano Olmi
- Stefano Piero Bernardo Cioffi
- Stefano Salizzoni
- Stefano Scabini
- Stefano Turi
- Stylianos Korasidis
- Susumu Matsushime
- Takashi Matsumoto
- Takashi Ouchi
- Takayuki Yamada
- Takeshi Nomura
- Takeshi Sasaki
- Takuya Saito
- Tasuku Oyama
- Tatsuki Hoshino
- Tatsuro Abe
- Tatsuya Kida
- Tedesco Silvia
- Teresa Perra
- Teruyuki Hiraki
- Tetsuya Kushikata
- Tiziana Frusca
- Tomio Ueno
- Tommaso Cai
- Tommaso Campagnaro
- Tommaso Cornali
- Tommaso Giuliani
- Tommaso Grassi
- Tommaso Maria Manzia
- Tommaso Pollini
- Tomohide Takei
- Tomohiro Chaki
- Tomoko Irisawa
- Tomomi Ogihara
- Tomoya Irie
- Toshimasa Okada
- Toshiya Shiga
- Toshiyuki Mizota
- Tsutomu Namikawa
- Tsuyoshi Sano
- Uberto Fumagalli Romario
- Ugo Grossi
- Umberto Bracale
- Umberto Cortinovis
- Umberto Scovazzi
- Valentina Bianchi
- Valentina Chiappa
- Valentina D'alessandro
- Valentina Iori
- Valentina Manciocco
- Valentina Marchionini
- Valentina Mastrofilippo
- Valentino Valentini
- Valeria Fico
- Valeria Quintodei
- Valerio Cozza
- Vanessa Rossi
- Veronica De Simone
- Vincenzo Dario Mandato
- Vincenzo Denaro
- Vincenzo Maiuri
- Vincenzo Maria Mazzaferro
- Vincenzo Ricchiuti
- Vinno Savelli
- Vito Andrea Capozzi
- Vito Chiantera
- Vito D'andrea
- Vittoria Bellato
- Vittorio Aprile
- Vittorio Arici
- Yasushi Innami
- Yoji
- Yoshihiko Chiba
- Yoshihiko Deguchi
- Yoshinori Fujiwara
- Yu Kaiho
- Yui Inoue
- Yuka Matsuki
- Yuko Koga
- Yuri Sekiya
- Yuta Nakamura
- Publication venue
- Publication date
- 01/01/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or >= 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
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- Yilmazlar Tuncay
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- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
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- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
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- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)