Artistic Business Management Utilizing Art Thinking to Create Inner and Outer Wealth for Businesses

This project investigates ways to utilize art thinking in business with the goal of establishing a framework to design a human-centric business management model – Artistic Business Management – for businesses to realize their full potential of producing inner wealth, outer wealth, and societal wealth. Art is represented in many forms, but the common theme in all is the benefit of cultivating inner wealth. Yet, the process of creating art often overshadows its being: the wealth of knowledge in creating inner wealth and the thinking method are not harnessed outside of the art world. On the other hand, in business, where outer wealth is created, the wealth creation system has developed in an exchange of our inner wealth, resulting in a situation where the majority of workers are overworked and disengaged. However, both types of wealth are essential in our wellbeing at an individual level as well at societal level. This report aims to transform such challenges into opportunities by merging the strengths of art and business together to introduce a new process of wealth creation. This report utilizes ideas from the evolution and history of art and business, current issues, expectations, and a case study of a successful business that utilizes art thinking in its management in order to formulate a framework that realizes human-centric innovation in business management. The final deliverable is the Artistic Business Management Mindset Model that promotes human-centric business management. It can be used to design a business that achieves both inner wealth and outer wealth through its operation

Radiation-induced marked reduction in hematopoietic progenitor cells in infant leukemia prone C3H/He mouse

Background: Age–at–exposure is a critical factor that influences the risk of radiation leukemogenesis. Whereas adult C3H/He mice are prone to develop myeloid leukemia after ionizing-radiation (IR) exposure, fetal and neonatal mice are resistant. Nakano et al. reported that dose response of chromosomal translation in hematopoietic cells was not observed in mice irradiated in utero or soon after birth. They hypothesized that the fetal or neonatal hematopoietic stem cells are genetically highly sensitive to ionizing radiation, so that the aberrant cells disappear soon after IR exposure. The purpose of this study was to determine the sensitivity to IR of developing hematopoietic cells both in vitro and in vivo. \nExperimental procedures: After in vivo gamma-ray irradiation to the 1 week-old to 14 week-old C3H/He mice, the survival of hematopoietic progenitor cells was determined by both colony forming assay in vitro using MthoCult kit and spleen colony formation assay in vivo. The gene expression profiles of bone marrow cells from 1 week-old and 8 week-old mice were also examined. \nResults: A marked reduction in the number of colony forming cells was observed after in vivo irradiation in the 1 week-old mice; the colony forming unit-granulocyte macrophage (CFU-GM), burst-forming unit-erythroid (BFU-E) and colony forming unit-spleen (CFU-S) of irradiated 1 week-old mice were more radiosensitive than those of older ages. Interestingly, in vitro irradiation did not show age difference between 1 week-old mice to 14 week-old mice. This suggests that in vivo microenvironment and/or its response to IR critically affects the radiation sensitivity of hematopoietic progenitor cells.Further, the gene expression profiles of bone marrow cells revealed that expression of cytokines and chemokines which can stimulate hematopoietic progenitor cell growth or survival, were reduced in 1 week-old mice compared to those of 8 week-old mice. \nConclusion: These results demonstrate that hematopoietic progenitor cells of neonatal stage are radiation sensitive, which may associate the lack of expression of survival cytokine and chemokine after ionizing radiation.14th International Congress of Radiation Researc

Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice

Age at exposure is a critical factor that influences the risk of radiation-induced leukemia, which arises from hematopoietic stem cells. However, little is known about the effect of age on the radiation response in these cells. Here we examined the radiation response of hematopoietic stem and progenitor cells in infant (1 week old), juvenile (3 weeks), and adult (8 and 14 weeks) C3H/He mice, which are susceptible to radiation induction of myeloid leukemia. We first demonstrated that infant cells were the most susceptible to radiation-induced cell killing. However, in vitro irradiation of these cells showed no age differences, suggesting that radiation sensitivity is ascribed to the bone marrow microenvironment rather than to the intrinsic nature of progenitors themselves. Expression profiles of bone marrow tissues revealed that radioprotective chemokine and cytokine expression was dependent on age at exposure and time after irradiation. There was no difference, however, in the basal expression of these factors among age groups. In contrast, radiation induction of Csf2 and Fgf1 was evident in adult tissues, but not in infant tissues. These results suggest that the decreased survival of hematopoietic stem and progenitor cells in irradiated infant mice may be attributed to a failure to induce a subset of radioprotective cytokines in the bone marrow microenvironment