EVALUATION OF RETINAL VESSEL DIAMETERS IN EYES WITH ACTIVE CENTRAL SEROUS CHORIORETINOPATHY

PURPOSE: To compare the retinal vessel diameters of healthy eyes and active central serous chorioretinopathy (CSC) eyes, and to evaluate possible effect of retinal vessel diameter alterations on the pathogenesis of CSC. METHODS: This retrospective study included 39 patients with CSC and 34 healthy individuals. Spectralis optical coherence tomography + HRA with an infrared reflectance image were used to evaluate structure of retinal vessels in the circular region around the optic disc. For each eye, vertical inner and outer diameters of the four major arteries and veins were measured using infrared reflectance images, and vessel wall thicknesses were also calculated based on inner and outer diameters. RESULTS: The 304 vessels of the 39 active CSC eyes and 266 vessels of the 34 healthy eyes were used in the analyses. The mean venous wall thickness in active CSC eyes was significantly thicker than that in healthy eyes (40.0 ± 4.9 vs. 33.5 ± 4.1 μm, P = 0.001), whereas the mean venous inner diameter in active CSC eyes was significantly narrower (52.5 ± 9.7 vs. 61.3 ± 8.1 μm, P = 0.001). Also, the mean venous outer diameter was wider in CSC eyes, albeit not significantly (131.1 ± 7.0 vs. 128.5 ± 8.4 μm, P = 0.074). CONCLUSION: Our results suggest that the alterations of retinal venous diameters may play a potential role in the pathogenesis of CSC in addition to alterations in choroidal thickness

The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex (R)) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion

Purpose: To investigate the effect of age on dexamethasone intravitreal implant (Ozurdex (R)) response in macular edema secondary to branch retinal vein occlusion (BRVO). Methods: Seventy-three eyes of 73 patients with macular edema secondary to BRVO were recruited in the study. The patients in the study were divided into the following four groups according to their ages: group 1 (= 80 years). Single-dose Ozurdex injection was applied to all patients. The effectiveness of Ozurdex treatment on macular edema is evaluated via optical coherence tomography (OCT) according to the age groups. Results: Two months after Ozurdex injection, mean reduction of central retinal thickness in groups 1, 2, 3, and 4 were -466.4 +/- 149.6, -379.7 +/- 238.7, -280.1 +/- 233.0, and -180.5 +/- 81.4 mu m, respectively. This reduction of central retinal thickness decreased with aging (p = 0.001). Also, ages of patients were negatively correlated with the mean reduction of central retinal thickness for the whole study group (r = -0.439, p < 0.001). Conclusion: Our study revealed that the effectiveness of Ozurdex treatment decreases with aging

Short-term effects of intravitreal dexamethasone implant (OZURDEX (R)) on choroidal thickness in patients with naive branch retinal vein occlusion

Purpose: The objective of this study was to evaluate subfoveal choroidal thickness (SFCT) using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with naive branch retinal vein occlusion (BRVO) before and after intravitreal dexamethasone implant (Ozurdex (R)) injection

Evaluations of Corneas in Eyes with Isolated Iris Coloboma

Purpose: We aimed to evaluate the differences in the corneas of eyes with isolated iris coloboma.Methods: This study was designed as a prospective study. Among patients who applied to our hospital within the last 3-year period, those with isolated iris coloboma in one eye and a completely normal contralateral eye were included in the study. In addition to a complete ophthalmologic examination, all patients were scanned by Pentacam Scheimpflug camera in the dark, and a corneal endothelium cell count was taken using a Topcon Specular Microscope. Data entered using SPSS software were then evaluated by paired t-test; p < 0.05 value was considered statistically significant.Results: Nine patients, seven men and two women, with a mean age of 35.77 22.50 (range 8-60) years, were included in the study. In comparison to normal eyes, the colobomatous eyes were statistically found to have lower keratometry values in diopters (43.82 +/- 2.17, 44.46 +/- 1.86; p = 0.040), a greater negative asphericity (Q value) (-0.38 +/- 0.07, -0.22 +/- 0.20; p = 0.042), increased corneal thickness (569.78 +/- 25.42, 537.33 +/- 27.36; p < 0.001), decreased anterior chamber depth (2.50 +/- 0.32, 2.81 +/- 0.50; p = 0.005), a shallower angle (30.51 +/- 10.68, 35.29 +/- 9.99; p = 0.057), higher best-fit sphere (BFS) values of the anterior and posterior corneal surfaces (7.88 +/- 0.39, 7.67 +/- 0.37; p = 0.001; 6.40 +/- 0.26, 6.23 +/- 0.19; p = 0.006), larger pupil diameter (3.48 +/- 0.49, 2.80 +/- 0.34; p = 0.001), smaller horizontal corneal diameter (HCD) (11.06 +/- 0.42; 11.26 +/- 0.45; p = 0.009), and higher value of endothelial cell density (ECD) (3161 +/- 431; 2923 +/- 590; p = 0.031).Conclusion: We have determined that a number of factors such as keratometry values, particularly of the corneal endothelium, are different from those of normal eyes. These differences should be taken into account in the follow-up and treatment of eyes with iris coloboma

Effectivity of intraoperative adjustable suture technique in horizontal strabismus

AIM:To compare the long-term effectivity of intraoperative adjustable suture technique with traditional non-adjustable strabismus surgery.METHODS:Two hundred and thirty-three patients, who underwent strabismus surgery either with traditional procedures or one-stage intraoperative adjustable suture technique, were included in our long-term follow-up study. One hundred and eighteen patients were evaluated in traditional surgery group (TSG) and 115 who underwent adjustable suture were in the one-stage intraoperative adjustable surgery group (ASG). In this group 9 patients had paralytic strabismus and 16 had reoperations, 2 patients had restrictive strabismus related to thyroid eye disease. The mean follow up in the TSG was 26.2 months and it was 24.8 months in the ASG group.RESULTS:In patients with exotropia (XT) the mean correction of deviation for near fixation in ASG (32.4±13.2PD) and in TSG (26.4±8.2PD) were similar (P=0.112). The correction for distant fixation in ASG (33.2±11.4PD) and TSG (30.9±7.2PD) were not significantly different (P=0.321). In patients with esotropia (ET) even the mean correction of deviation for both near (31±12PD) and distant (30.6±12.8PD) fixations were higher in ASG than in TSG, for both near (28.27±14.2PD) and distant (28.9±12.9PD) fixations, the differences were not significant (P=0.346, 0.824 respectively). The overall success rate of XT patient was 78.9% in TSG and 78.78% in ASG, the difference was not significant (P=0.629). The success rates were 78.75% in TSG and 75.51% in ASG in ET patient, which was also not significantly different (P=0.821).CONCLUSION:Although patients in ASG had more complex deviation such as paralysis, reoperations and restrictive strabismus, success rates of this tecnique was as high as TSG which did not contain complicated deviation. One-stage intraoperative adjustable suture technique is a safe and effective method for cooperative patient who has complex deviation

Systemic Endothelial Function in Primary Open-Angle Glaucoma

Objective. We aimed to assess peripheral vascular endothelial function in open-angle glaucoma (POAG) by measuring flow-mediated dilatation (FMD). Materials and Methods. The study included 20 cases with POAG (group 1, mean age 58.68±13.3 years) and 30 healthy individuals (group 2, mean age 58.68±13.6 years). In all cases, responses of endothelial function were assessed by a cardiologist through measurement of FMD following brachial artery occlusion. Results. Mean percent of FMD, an indicator of endothelial function, was found to be 11.9±4.2% in group 1 and 12.3±4.4% in group 2 (P=0.86). Conclusion. No impairment in systemic vascular function of cases with POAG suggests that POAG could be a local disorder rather than being a component of systemic disease

Assessing posterior ocular structures in beta-thalassemia minor

Purpose The aim of this study was to investigate the effect of beta-thalassemia minor on choroidal, macular, and peripapillary retinal nerve fiber layer thickness