A comprehensive overview on nanofiber technology and their advancements in the field of pharmaceuticals

Nanotechnology is a growing technology that has been marked as the most vital scientific and commercial venture across the world with great benefits. Globally many researchers are involved in the development of newer types of nanomaterials through modifications of various fabrication techniques. Nanofibers have been an emerging trend in the field of nanomaterials due to its unique physicochemical characteristics. Properties such as high surface area and high porosity absorbance ratio with the interconnected fibrous networks makes nanofibers unique. The current review explores the present status and upcoming advancements in the field of nanofiber technology. The article is focused on the various preparation techniques and applications in medicine, tissue engineering and regenerative medicine and pharmaceuticals. Despite the advancements, the limitations and future prospects in the area of nanofiber technology have been highlighted

In-vitro and in-vivo evaluation of Cimetidine loaded mucoadhesive microspheres

In the present research work mucoadhesive microspheres of cimetidine was prepared using ionotropic gelation technique. All the microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, stability studies and for in vitro release kinetics and found to be within the limits. Among all the formulations M12 was selected as optimized formulation based on the physicochemical and release studies.In vitro drug release study of optimized formulation M12 showed 99.12% after 12 h in a controlled manner, which is essential for anti ulcer therapy. The innovator cimetine conventional tablet showed the drug release of 96.15% within 1 h. The drug release of cimetidine optimized formulation M12 followed zero order and Higuchi kinetics indicating diffusion controlled drug release. In vivo studies revealed that the optimized formulation M12 gave the highest AUC and Tmax. The results are indicative of cimetidine as mucoadhesive microspheres for improving the oral bioavailability with controlled drug release

In-vitro and in-vivo evaluation of Cimetidine loaded mucoadhesive microspheres

In the present research work mucoadhesive microspheres of cimetidine was prepared using ionotropic gelation technique. All the microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, stability studies and for in vitro release kinetics and found to be within the limits. Among all the formulations M12 was selected as optimized formulation based on the physicochemical and release studies.In vitro drug release study of optimized formulation M12 showed 99.12% after 12 h in a controlled manner, which is essential for anti ulcer therapy. The innovator cimetine conventional tablet showed the drug release of 96.15% within 1 h. The drug release of cimetidine optimized formulation M12 followed zero order and Higuchi kinetics indicating diffusion controlled drug release. In vivo studies revealed that the optimized formulation M12 gave the highest AUC and Tmax. The results are indicative of cimetidine as mucoadhesive microspheres for improving the oral bioavailability with controlled drug release

SYNTHESIS, IN SILICO STUDIES AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF 4-SUBSTITUTED BENZYLIDENE-2-(PHENOXYMETHYL) OXAZOL-5(4H)-ONES

Objective: Arylidene-1, 3-oxazol-5-ones represent potential antibacterial agents. In the present work, a series of 4-substituted benzylidene-2- (phenoxymethyl) oxazol-5(4H)-ones were synthesized and screened for antibacterial activity against Gram-negative bacteria Escherichia coli. To explore plausible mechanisms, synthesized compounds were docked with DNA-Gyrase enzyme. Methods: All the reactants, phenoxy acetyl chloride, acetic anhydride, sodium acetate, substituted aromatic aldehydes, and glycine were triturated in a mortar by mechanical stirring. The antibacterial potentiality of the compounds was screened against E. coli using the disk diffusion method and the activity was recorded as a zone of inhibition. Results: Compound 2d, possessing 3, 4, 5-trimethoxy functionality on benzylidene ring exhibited the highest activity with 19 mm of the zone of inhibition which might be due to its higher interactions with DNA-Gyrase enzyme (ΔG-8.41 kcal/mol). Compounds 2a, 2b, and 2c exhibited moderate activity in the antimicrobial assay as well as in docking study indicating the positive contribution of substitution on benzylidene ring. Conclusion: A series of 4-substituted benzylidene-2-(phenoxymethyl) oxazol-5(4H)-ones were synthesized and evaluated for antibacterial activity. Compounds 2a, 2b, and 2c displayed moderate activity whereas 2d showed maximum zone of inhibition (19 mm). The good activity of these derivatives presumed to be due to the conformational flexibility of phenoxy methylene moiety which can be well accommodated in the target binding site

BLENDED MODE OF TEACHING AND LEARNING: CONCEPTS & TECHNIQUES

Technological progression has continued to surpass new grounds in several areas of human endeavour involved in the educational system. The introduction of technology into education sector especially in the facet of teaching has brought about a significant transformation from the traditional teaching practices toadvanced digital teaching methodology. Blended learning is the amalgamation of traditional face-to-face learning with technology, internet, as well as distance learning. The novel approach is emerging progressively in the education system in recent times. The present article explores the concept of blended learning & its didactic prospectsin order to make an effective changeover from a traditional learning model to an integrated modelapplicable, with digitalsettings and resources being extensively used. Blended learning is an effective method of teaching which is flexible as well as easy to access. Furthermore, it can increase students’ motivation & their accomplishment of the course