69 research outputs found
Ethyl 4-hydroxy-2,6-diphenyl-1-[2-(piperidin-1-yl)acetyl]-1,2,5,6-tetrahydropyridine-3-carboxylate
In the title compound, C27H32N2O4, the piperidine and tetrahydropyridine rings adopt chair and half-chair conformations, respectively. The dihedral angle between the two phenyl rings is 32.9 (1)°. The molecular structure is stabilized by a strong intramolecular O—H⋯O hydrogen bond, generating an S(6) motif. In the crystal, intermolecular C—H⋯O interactions form a ribbon-like structure along the a axis
1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one
In the title compound C19H16ClF2NO2, the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H⋯O and C—H⋯F hydrogen bonds and an intermolecular π–π interaction [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H⋯O and C—H⋯F intermolecular interactions generate chains running along the a axis, while a centrosymmetric R
2
2(16) ring involving C—H⋯O interactions is formed centred at (1/2, 1/2, 0)
Ethyl 1-[2-(1H-benzotriazol-1-yl)acetyl]-4-hydroxy-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
In the title compound, C28H26N4O4, the tetrahydropyridine ring adopts a boat conformation. The two phenyl rings form dihedral angles of 88.64 (8) and 59.28 (10)° with the best plane through the tetrahydropyridine ring. The dihedral angle between the two phenyl rings is 82.55 (10)°. The benzotriazole ring system is essentially planar, with a maximum deviation of 0.009 (1) Å from the least-squares plane. The molecular conformation is stabilized by an intramolecular O—H⋯O hydrogen bond, generating an S(6) motif
Ethyl 1-(2-bromopropanoyl)-4-hydroxy-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
The title compound, C23H24BrNO4, crystallizes with two independent molecules per asymmetric unit. The methyl group of the ethoxycarbonyl unit is disordered over two positions, with occupancies of 0.715 (12) and 0.285 (12) in one of the independent molecules, and 0.529 (11) and 0.471 (11) in the other molecule. In one of the independent molecules, the tetrahydropyridine ring adopts a half-chair conformation, while in the other it is in a distorted envelope conformation. In each independent molecule, an intramolecular O—H⋯O hydrogen bond generates an S(6) ring motif. The two independent molecules are linked via C—H⋯O hydrogen bonds, forming a chain along the c axis
1-Bromoacetyl-2,6-bis(4-methoxyphenyl)-3,5-dimethylpiperidin-4-one
In the title compound, C23H26BrNO4, the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9 (1)°. The two methoxy groups are close to coplanar with the attached benzene rings [C—C—O—C torsion angles of 6.3 (5) and 16.4 (4)°]. A weak C—H⋯Br intramolecular interaction is observed. In the crystal structure, molecules are linked into a chain along [101] by intermolecular C—H⋯O hydrogen bonds. A short intermolecular Br⋯O contact [3.063 (2) Å] is observed
r-2,c-6-Bis(2-methoxyphenyl)-t-3,t-5-dimethylpiperidin-4-one acetic acid solvate
In the title compound, C21H25NO3·C2H4O2, the piperidone ring adopts a chair conformation. The two methoxy groups are nearly coplanar with the aromatic rings to which they are attached. The dihedral angle between the two aromatic rings is 60.9 (2)°. There are two short intramolecular N—H⋯O contacts. The crystal packing is stabilized by intermolecular O—H⋯N and C—H⋯O interactions
1-(2-Bromoacetyl)-3-methyl-2,6-diphenylpiperidin-4-one
In the title compound, C20H20BrNO2, the piperidone ring adopts a boat conformation. The phenyl rings are oriented at dihedral angles of 97.8 (2) and 96.0 (1)° with respect to the best plane through the piperidine ring. The dihedral angle between the two phenyl rings is 49.7 (1)°. In the crystal, bifurcated C—H⋯O hydrogen bonds form a R
2
1(7) ring motif, linking the molecules into centrosymmetric dimers
Ethyl 4-hydroxy-2,6-diphenyl-1-(2-thiomorpholinoacetyl)-1,2,5,6-tetrahydropyridine-3-carboxylate
In the title compound, C26H30N2O4S, the thiomorpholine ring adopts a chair conformation whereas the tetrahydropyridine ring is in a half-chair conformation. The dihedral angle between the two phenyl rings is 33.3 (2)°. A strong intramolecular O—H⋯O hydrogen bond generates an S(6) motif. In the crystal, molecules are linked by intermolecular C—H⋯O hydrogen bonds, generating a ribbon-like structure propagating along the a axis
Ethyl 4-hydroxy-2,6-diphenyl-1-(2-thiomorpholinopropanoyl)-1,2,5,6-tetrahydropyridine-3-carboxylate
In the title compound, C27H32N2O4S, the thiomorpholine ring adopts a chair conformation and the tetrahydropyridine ring is in a distorted envelope conformation. The molecular structure is stabilized by an intramolecular O—H⋯O interaction and the crystal packing is stabilized by an intermolecular C—H⋯O interaction, generating an S(6) motif and a dimer of the type R
2
2(18), respectively
1-Chloroacetyl-2,6-bis(2-methoxyphenyl)-3,5-dimethylpiperidin-4-one
The piperidone ring in the title compound, C23H26ClNO4, adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C—H⋯π intramolecular interaction is observed. The crystal packing is stabilized by a C—H⋯O intermolecular interaction, generating a chain with a C(9) motif along the a axis
- …