Ethyl 4-hy­droxy-2,6-diphenyl-1-[2-(piperidin-1-yl)acet­yl]-1,2,5,6-tetra­hydro­pyridine-3-carboxyl­ate

In the title compound, C27H32N2O4, the piperidine and tetra­hydro­pyridine rings adopt chair and half-chair conformations, respectively. The dihedral angle between the two phenyl rings is 32.9 (1)°. The mol­ecular structure is stabilized by a strong intra­molecular O—H⋯O hydrogen bond, generating an S(6) motif. In the crystal, inter­molecular C—H⋯O inter­actions form a ribbon-like structure along the a axis

1-Chloro­acetyl-2,6-bis­(3-fluoro­phen­yl)piperidin-4-one

In the title compound C19H16ClF2NO2, the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O inter­molecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H⋯O and C—H⋯F hydrogen bonds and an inter­molecular π–π inter­action [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H⋯O and C—H⋯F inter­molecular inter­actions generate chains running along the a axis, while a centrosymmetric R 2 2(16) ring involving C—H⋯O inter­actions is formed centred at (1/2, 1/2, 0)

Ethyl 1-[2-(1H-benzotriazol-1-yl)acet­yl]-4-hy­droxy-2,6-diphenyl-1,2,5,6-tetra­hydro­pyridine-3-carboxyl­ate

In the title compound, C28H26N4O4, the tetra­hydro­pyridine ring adopts a boat conformation. The two phenyl rings form dihedral angles of 88.64 (8) and 59.28 (10)° with the best plane through the tetra­hydro­pyridine ring. The dihedral angle between the two phenyl rings is 82.55 (10)°. The benzotriazole ring system is essentially planar, with a maximum deviation of 0.009 (1) Å from the least-squares plane. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond, generating an S(6) motif

1-Bromo­acetyl-2,6-bis­(4-methoxy­phen­yl)-3,5-dimethyl­piperidin-4-one

In the title compound, C23H26BrNO4, the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9 (1)°. The two meth­oxy groups are close to coplanar with the attached benzene rings [C—C—O—C torsion angles of 6.3 (5) and 16.4 (4)°]. A weak C—H⋯Br intra­molecular inter­action is observed. In the crystal structure, mol­ecules are linked into a chain along [101] by inter­molecular C—H⋯O hydrogen bonds. A short inter­molecular Br⋯O contact [3.063 (2) Å] is observed

Ethyl 1-(2-bromo­propano­yl)-4-hydr­oxy-2,6-diphenyl-1,2,5,6-tetra­hydro­pyridine-3-carboxylate

The title compound, C23H24BrNO4, crystallizes with two independent mol­ecules per asymmetric unit. The methyl group of the ethoxy­carbonyl unit is disordered over two positions, with occupancies of 0.715 (12) and 0.285 (12) in one of the independent mol­ecules, and 0.529 (11) and 0.471 (11) in the other mol­ecule. In one of the independent mol­ecules, the tetra­hydro­pyridine ring adopts a half-chair conformation, while in the other it is in a distorted envelope conformation. In each independent mol­ecule, an intra­molecular O—H⋯O hydrogen bond generates an S(6) ring motif. The two independent mol­ecules are linked via C—H⋯O hydrogen bonds, forming a chain along the c axis

r-2,c-6-Bis(2-methoxy­phen­yl)-t-3,t-5-dimethyl­piperidin-4-one acetic acid solvate

In the title compound, C21H25NO3·C2H4O2, the piperidone ring adopts a chair conformation. The two meth­oxy groups are nearly coplanar with the aromatic rings to which they are attached. The dihedral angle between the two aromatic rings is 60.9 (2)°. There are two short intra­molecular N—H⋯O contacts. The crystal packing is stabilized by inter­molecular O—H⋯N and C—H⋯O inter­actions

1-(2-Bromo­acet­yl)-3-methyl-2,6-diphenyl­piperidin-4-one

In the title compound, C20H20BrNO2, the piperidone ring adopts a boat conformation. The phenyl rings are oriented at dihedral angles of 97.8 (2) and 96.0 (1)° with respect to the best plane through the piperidine ring. The dihedral angle between the two phenyl rings is 49.7 (1)°. In the crystal, bifurcated C—H⋯O hydrogen bonds form a R 2 1(7) ring motif, linking the mol­ecules into centrosymmetric dimers

Ethyl 4-hy­droxy-2,6-diphenyl-1-(2-thio­morpholino­acet­yl)-1,2,5,6-tetra­hydro­pyridine-3-carboxyl­ate

In the title compound, C26H30N2O4S, the thio­morpholine ring adopts a chair conformation whereas the tetra­hydro­pyridine ring is in a half-chair conformation. The dihedral angle between the two phenyl rings is 33.3 (2)°. A strong intra­molecular O—H⋯O hydrogen bond generates an S(6) motif. In the crystal, mol­ecules are linked by inter­molecular C—H⋯O hydrogen bonds, generating a ribbon-like structure propagating along the a axis

Ethyl 4-hydr­oxy-2,6-diphenyl-1-(2-thio­morpholinopropano­yl)-1,2,5,6-tetra­hydro­pyridine-3-carboxyl­ate

In the title compound, C27H32N2O4S, the thio­morpholine ring adopts a chair conformation and the tetra­hydro­pyridine ring is in a distorted envelope conformation. The mol­ecular structure is stabilized by an intra­molecular O—H⋯O inter­action and the crystal packing is stabilized by an inter­molecular C—H⋯O inter­action, generating an S(6) motif and a dimer of the type R 2 2(18), respectively

1-Chloro­acetyl-2,6-bis­(2-methoxy­phen­yl)-3,5-dimethyl­piperidin-4-one

The piperidone ring in the title compound, C23H26ClNO4, adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C—H⋯π intra­molecular inter­action is observed. The crystal packing is stabilized by a C—H⋯O inter­molecular inter­action, generating a chain with a C(9) motif along the a axis