Oxidative Stress in Patients With Acne Vulgaris

Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared with control group, the relation between the severity and distribution of acne, and the correlation of each enzyme level were researched. CAT and G6PD levels in patients were found to be statistically decreased, and SOD and MDA levels were found to be statistically increased (P < .001). However, any statistical difference and correlation could not be found between the severity and distribution of lesions and the mean levels of enzymes. In addition, we found that each enzyme is correlated with one another. Our findings show that oxidative stress exists in the acne patients. It will be useful to apply at least one antioxidant featured drug along with the combined acne treatment

Oxidative Stress in Patients With Nongenital Warts

Comparison of oxidative stress status between subjects with or without warts is absent in the literature. In this study, we evaluated 31 consecutive patients with warts (15 female, 16 male) and 36 control cases with no evidence of disease to determine the effects of oxidative stress in patients with warts. The patients were classified according to the wart type, duration, number, and location of lesions. We measured the indicators of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood by spectrophotometry. There was a statistically significant increase in levels of CAT, G6PD, SOD activities and MDA in the patients with warts compared to the control group (P < .05). However, we could not define a statistically significant correlation between these increased enzyme activities and MDA levels and the type, the duration, the number, and the location of lesions. We determined possible suppression of T cells during oxidative stress that might have a negative effect on the prognosis of the disease. Therefore, we propose an argument for the appropriateness to give priority to immunomodulatory treatment alternatives instead of destructive methods in patients with demonstrated oxidative stress

Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity

Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-γ, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IFN-γ, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity

The effect of thyroid hormones in psoriasis vulgaris

BACKGROUND AND AIMS: Certain endocrinological disturbances are assumed to exacerbate psoriasis. In this study we compared the serum thyroid hormone levels of a group of psoriasis patients with that of a control group. METHODS: The total T3 (TT3), free T3 (FT3), total T4 (TT4), free T4 (FT4) and TSH levels obtained from the sera of 103 psoriatics (37 males and 66 females) and 96 controls (40 male and 56 female) were measured by immunological assay. RESULTS: Statistical assessments displayed no differences in TT3, FT4 and TSH serum levels for the two groups. Differences between the means of serum TT4 (P=0.033) and serum FT3 (P=0.041) levels showed statistical differences among the groups. We also found that at least one thyroid hormone level in the blood was increased in 23 patients of the psoriatic group compared to 9 patients in the control group (P=0.022). The average Psoriasis Area and Severity Index scores in this patient group were significantly higher than in those with normal hormone levels (P&lt;0.001). CONCLUSIONS: The role of thyroid hormones in the etiopathogenesis of psoriasis and the effects of such differences in psoriatic patients must be investigated with wider and comprehensive laboratory and clinical studies

The effect of thyroid hormones in psoriasis vulgaris

BACKGROUND AND AIMS: Certain endocrinological disturbances are assumed to exacerbate psoriasis. In this study we compared the serum thyroid hormone levels of a group of psoriasis patients with that of a control group. METHODS: The total T3 (TT3), free T3 (FT3), total T4 (TT4), free T4 (FT4) and TSH levels obtained from the sera of 103 psoriatics (37 males and 66 females) and 96 controls (40 male and 56 female) were measured by immunological assay. RESULTS: Statistical assessments displayed no differences in TT3, FT4 and TSH serum levels for the two groups. Differences between the means of serum TT4 (P=0.033) and serum FT3 (P=0.041) levels showed statistical differences among the groups. We also found that at least one thyroid hormone level in the blood was increased in 23 patients of the psoriatic group compared to 9 patients in the control group (P=0.022). The average Psoriasis Area and Severity Index scores in this patient group were significantly higher than in those with normal hormone levels (P<0.001). CONCLUSIONS: The role of thyroid hormones in the etiopathogenesis of psoriasis and the effects of such differences in psoriatic patients must be investigated with wider and comprehensive laboratory and clinical studies

Evaluation of local trace element status and 8-Iso-prostaglandin F-2a concentrations in patients with Tinea pedis

WOS: 000367572600001PubMed ID: 26740800Background: Tinea pedis (TP) is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. Up to the now, the local 8-iso-prostaglandin F-2a (8-iso-PGF(2a)), concentration as oxidative stress biomarker and trace elements status have not been published in patients with TP. The aim of this study is to evaluate the relationship between oxidative stress and trace elements (Cu, Zn, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder. Methods: Forty-three consecutive patients with a diagnosis of unilateral interdigital TP were enrolled in this study. The samples were obtained by scraping the skin surface. 8-iso-PGF(2a) concentrations in scraping samples were determined by ELISA. In addition, the levels of Se, Zn and Cu in scraping samples were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction. Results: Oxidative stress was confirmed by the significant elevation in 8-iso-PGF(2a) concentrations (p 0.05). Conclusions: Our results showed that there is a possible link between oxidative stress (increased 8-iso-PGF(2a) concentrations) and imbalanced of trace elements status in lesional area of TP patients. The use of antifungal agents together with both Zn and Se drugs could be helpful in the both regression of disease and in shortening the duration of disease