Controlled Solid Phase Peptide Bond Formation Using <i>N</i>‑Carboxyanhydrides and PEG Resins in Water.

The increasing need for large quantities of biologically active peptides for the market strongly raised the problem of the environmental sustainability of their synthesis. In this respect, we describe herein a solid phase procedure in water, using PEG peptide amide resins and NCAs under controlled conditions. This procedure afforded with reasonable yield and purity a short peptide amide, without the need of coupling reagents or protecting groups

Diagnostic Implementation of Fast and Selective Integrin-Mediated Adhesion of Cancer Cells on Functionalized Zeolite L Monolayers

The rapid and exact identification and quantification of specific biomarkers is a key technology for always achieving more efficient diagnostic methodologies. We present the first application of a nanostructured device constituted of patterned self-assembled monolayers of disk-shaped zeolite L coated with the cyclic integrin ligand c­[RGDfK] via isocyanate linker, to the rapid detection of cancer cells. With its high specificity toward HeLa and Glioma cells and fast adhesion ability, this biocompatible monolayer is a promising platform for implementation in diagnostics and personalized therapy formulation devices