Diagnostic Implementation of Fast and Selective Integrin-Mediated
Adhesion of Cancer Cells on Functionalized Zeolite L Monolayers
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Abstract
The rapid and exact identification
and quantification of specific
biomarkers is a key technology for always achieving more efficient
diagnostic methodologies. We present the first application of a nanostructured
device constituted of patterned self-assembled monolayers of disk-shaped
zeolite L coated with the cyclic integrin ligand c[RGDfK] via isocyanate
linker, to the rapid detection of cancer cells. With its high specificity
toward HeLa and Glioma cells and fast adhesion ability, this biocompatible
monolayer is a promising platform for implementation in diagnostics
and personalized therapy formulation devices