Extension of CPE 454 Operating System

This project extended on the operating system I wrote in CPE 454 by adding additional features on top of the existing implementation. In order to implement them, I researched operating system design patterns and hardware details. I used wiki.osdev.org for most research, just like I did in CPE 454. The source code for the project is at https://github.com/josepharhar/jos

Aggregation Characterization of Wild-Type p53 and Six Common p53 Mutants

P53 is a tumor suppressor protein, which functions in maintaining the cell cycle. When p53 loses its function, cells may multiply at an uncontrolled rate and form tumors. This loss of function is linked to over fifty percent of human cancers. This investigation aims to explore the possible link between p53 aggregation and tumorigenesis. There is a possibility that p53, especially in mutant form, will aggregate beyond its normal tetrameric conformation and lose its function, leading to tumor formation. Wild-type p53 and six mutants, R175H, R175C, R248Q, R248W, R273C, and R273H (six of the most common mutations found in human cancers), were purified from E. coli using Ni-NTA agarose resin. Aggregation rates were monitored for the wild-type and each mutant by Thioflavin-T binding assays. Atomic force microscopy was used to visualize each of the p53 mutants pre-incubation and at time points that Thioflavin-T binding suggested the presence of aggregates. Utilizing this data, each mutant was characterized for its relative speed of aggregation; this suggests which mutants are more aggregation-prone. Combined with cell viability results, our data indicates that p53 aggregation of mutated variants is a contributing factor to tumorigensis. Those mutants with the greatest propensity to aggregate also appear to be those with the greatest ability to become immortal

Kako korisnici reagiraju na odzivni rječnik: slučaj Slovara sopomenk sodobne slovenščine

The Thesaurus of Modern Slovene is a responsive dictionary: it is compiled automatically from existing language resources while further developments of the dictionary include user participation. Many of the features introduced by the responsive model are new to the Slovene language community (e.g. data is extracted automatically and includes some errors; nonexperts are involved in dictionary compilation; the resource is never truly finished). With financial support from the Slovene Ministry of culture, a survey was conducted to gauge (potential) user opinions on the new features. The paper presents the results of the survey (n = 671) including statistical analyses of dependencies between the respondents’ opinions and their reported familiarity with the new dictionary, their age, and their professional occupation.Slovar spomenk sodobne slovenščine odzivni je rječnik koji je automatski generiran iz postojećih jezičnih resursa, a daljnji razvoj rječnika uključuje sudjelovanje korisnika. Mnoge značajke odzivnoga rječnika nove su slovenskoj jezičnoj zajednici (npr. podatci se crpe automatski i imaju određene pogreške, nestručnjaci sudjeluju u sastavljanju rječnika koji nikad nije u potpunosti završen). Uz financijsku potporu Slovenskoga ministarstva kulture provedeno je istraživanje kako bi se utvrdili stavovi korisnika o tim novim značajkama. U radu se prikazuju rezultati istraživanja (n = 671) uključujući statističku analizu zavisnosti stavova sudionika istraživanja i njihova poznavanja novoga rječnika, dobi i zanimanja

Learning to Look through the Eyes of Our Students: action research as a tool of inquiry

The story we are about to tell occurred when Gayle was a middle school science teacher and graduate student in Joanne’s seminar on the study of teaching. Gayle was trying to make sense of her science students’ indifference toward the environment, an attitude that concerned her as an environmentalist. She turned her inquiry into an action research project that sought to answer the question, ‘What are the assumptions that my middle school students have about their relationship with the environment?’ Joanne was mentoring Gayle in her action research study, and at the same time exploring Gayle’s perspective as an action researcher. Now, several years later, we are both action researchers and teacher educators and understand that we have been looking through the eyes of our students in order to become scholars of our own teaching

Odnos jezikovnih uporabnikov do splošnih enojezičnih slovarjev: slovenski vidik

Prispevek predstavlja rezultate slovenskega dela mednarodne raziskave o odnosu jezikovnih uporabnikov do splošnih enojezičnih slovarjev. Raziskava je potekala leta 2017 v okviru dejavnosti Evropske mreže za e-leksikografijo (ENeL). V Sloveniji je vprašalnik izpolnilo 619 posameznic in posameznikov, med katerimi so tako redni slovarski uporabniki kot tisti, ki slovarje uporabljajo redkeje. Rezultati kažejo, da vprašani do slovarskih podatkov najpogosteje in najraje dostopajo s pomočjo računalnika. Slovar se pogosto uporablja za preverbo ustreznosti jezikovnih izbir (lastnih in tujih), vendar njegova referenčnost ni razumljena kot absolutna, saj se ob informacijskih vrzelih uporabniki privzeto obračajo na številne druge vire. Slovar se tipično dojema kot izčrpen vir informacij o slovenščini, namenjen širši javnosti. Simbolna vloga slovarja (avtoriteta, nacionalni simbol) se v uporabniških odgovorih zrcali redkeje, implicitno pa jo nakazuje nenaklonjenost uporabnikov, da bi knjižni slovar oddali ali zavrgli, četudi uporabljajo le digitalno različico. Med vprašanimi vlada močna podpora javnemu financiranju priprave splošnih enojezičnih slovarjev, temu ustrezno pa se brezplačnost slovarja pojavlja že na drugem mestu prioritetnih značilnosti, takoj za zanesljivostjo vsebine. Med prioritetami se pojavita še enostavnost uporabe slovarja ter sodobnost vsebine. Izsledke raziskave je mogoče uporabiti pri razvoju slovarskih virov in za oblikovanje nadaljnjih korakov slovenskih slovaropisnih uporabniških raziskav

Network of coverage and treatments in physiotherapy in primary health care in the year of 2015

Uvod: Sistem zdravstvenega varstva se izvaja na treh ravneh: primarni, sekundarni in terciarni. Tudi fizioterapija se izvaja na vseh treh ravneh. Fizioterapevti na primarni ravni so del mreže javne zdravstvene službe in delo opravljajo v skladu s pogodbami, katere imajo izvajalci fizioterapevtskih storitev sklenjene z Zavodom za zdravstveno zavarovanje (ZZZS). Namen: Namen dela je poglobljena statistična analiza podatkov o številu obravnavanih primerov posameznih izvajalcev fizioterapije na primarni ravni, ter preveriti dostopnost do fizioterapevtskih storitev. Metode dela: Literatura je bila iskana v Cobbis-u in PubMed-u. Pregledana je bila zakonska podlaga in splošni dogovori. Podatki uporabljeni za statistično obdelavo so bili povzeti z spletnih strani ZZZS-ja. Od statističnih metod so bile uporabljene mere središčnosti in razpršenosti, procentni račun ter T- test za neodvisna vzorca. Rezultati: Skupno 161.412 obravnav je naredilo 506,61 fizioterapevtov. Fizioterapevt v povprečju pokriva 4.043 zavarovanih oseb. Med območnimi enotami se pojavljajo občutne razlike. Približno 49% obravnav so realizirali zdravstveni domovi. Planirano števila obravnav je doseglo 42% izvajalcev. Minimalno število obravnav je doseglo 85% izvajalcev. T-test je pokazal, da velikost tima ne vpliva na število obravnav. Razprava in sklep: Fizioterapevtska dejavnost na primarni ravni ni enakomerno porazdeljena znotraj Slovenije. Domnevo, da so koncesionarji naredili največ obravnav zavrnemo. Planiranega števila obravnav več kot polovica ustanov ni dosegla, minimalno število obravnav pa ustanove dosežejo. Ustanove z več fizioterapevti ne dosežejo večjega števila obravnav.Introduction: The healthcare system is performed on three levels: primary, secondary and tertiary. Physiotherapy is also carried out on all three levels. Providers of physiotherapy at the primary level are part of a network of public health services and work according to the agreements they have with the Health Insurance Institute (HII). Objectives: The purpose of the work is in-depth statistical analysis of data on the number of cases dealt with individual providers of physiotherapy at the primary level, and to check availability of physiotherapy services. Methods: The literature was searched in Cobiss and PubMed. The legal basis and general arrangements were also examined. The data used for the statistical analysis was summarized from the websites of the Health Insurance Institute of Slovenia. Statistical methods used are a degree of centrality and variability, percentage and T- test for independent samples. Results: Total of 161 412 treatments have been made by 506,61 physiotherapists. At the national level, a single program covers 4.043 insured individuals on average, between regional unites significant differences occur. Approximately 49% of treatments were made by health care centers. Planned number of treatments was reached by 42 % of the providers. Minimal number of treatments was reached by 85 % of the providers. T - Test showed that the size of the team does not affect the number of treatments. Discussion and conclusion: Physiotherapy activity at the primary level is not evenly distributed within Slovenia. The second hypothesis was rejectedthe most treatments were made by health centers. Planned number of treatments was not reached by more than half of providersthe minimum number of treatments is accessible. Providers with numerous teams do not reach a greater number of treatments

Otvoritvena konferenca raziskovalne mreže European Literacy Network (ELN)

V sklopu evropskega finančnega mehanizma COST, ki podpira meddržavno in meddisciplinarno povezovanje evropskih raziskovalcev oz. raziskav,1 med leti 2015 in 2018 poteka tudi aktivnost IS1401: Strengthening Europeans’ Capabilities by Establishing the European Literacy Network (ELN).2 Glavni namen aktivnosti je povezati raziskovalce, ki se na različnih področjih (jezikoslovje, pedagogika in specialna pedagogika, psihologija, medicina itd.) ukvarjajo z vprašanji branja in pisanja, primerjati pristope in rezultate ter razviti celostnejši pristop k problemom pismenosti – in raziskovanja pismenosti – v evropskem prostoru. Po uvodnih sestankih, na katerih so se začrtala osnovna delovna področja, je 8. in 9. novembra v Pragi potekala otvoritvena konferenca ELN

Študentje, škratje in nadškofje. Končnica -je v imenovalniku množine pri samostalnikih prve moške sklanjatve

Ena izmed oblikoslovnih posebnosti slovenskega jezika je možnost rabe končnice -je namesto -i v imenovalniku množine pri določenih samostalnikih prve moške sklanjatve (npr. študenti – študentje). Prispevek predstavlja rezultate korpusne analize, ki kaže, kateri slovenski samostalniki se v sodobni slovenščini pojavljajo s končnico-je in kako jih je mogoče nadalje kategorizirati ter na osnovi tega sklepati o tendencah posamezne od variant v rabi. Prispevek umešča nove ugotovitve ob informacije, ki jih o tej temi lahko iz obstoječih referenčnih priročnikov dobi zainteresirani jezikovni uporabnik

Uvodnik

Poseben tematski sklop letošnje prve številke vsebuje osem kratkih znanstvenih prispevkov, ki pregledno opisujejo trenutno stanje na področju leksikografije na Danskem, Švedskem, Norveškem, Hrvaškem, v Grčiji, Baskiji, Estoniji in Braziliji. Prispevki so nastali kot rezultat znanstvenega sodelovanja v evropski mreži ENeL – European Network of e-Lexicography [ISCH COST Action IS1305]