Bayesian methods for the design and analysis of complex follow-up studies

My doctoral research focused on two topics: i) models for the analysis of multi-state time-to-event data; and ii) decision-theoretic approaches for the design of clinical trials with a survival endpoint. For the first, I developed stochastic processes useful for the Bayesian non-parametric analysis of follow-up studies where patients may experience multiple events relevant to their prognosis. For the second, I developed an approach that uses data from early clinical trials to specify the statistical test used in a confirmatory survival study, accounting for the possible failure of standard assumptions. In this thesis, I describe 3 research papers that report my contributions. Part of my work has been conducted while a visiting researcher at the Dana-Farber Cancer Institute, Boston, Massachusetts (United States of America)

The cognitive effects of computational thinking: A systematic review and meta-analytic study

In this paper, we review and meta-analyze the findings of experimental studies published between 2006 and 2022 that examined the effects of coding and programming interventions on children's core and higher order executive functions (response inhibition, working memory, cognitive flexibility, planning and problem solving). The systematic review and meta-analysis aimed to address three research questions: 1) Which executive functions are most impacted by the teaching of CT? 2) Which instructional modality (educational robotics/virtual coding/unplugged coding) is most effective in enhancing executive function skills in learners aged 4–16 years? and 3) Does the cognitive effectiveness of coding vary with children's age? A total of 19 studies with 1523 participants met the selection criteria for the systematic review. The meta-analysis included 11 of those studies. The results reveal beneficial effects of structured virtual and tangible coding (educational robotics) activities for preschoolers and first graders, and significant effects of more unstructured virtual coding activities (e.g., Scratch-based) for older students. A multivariate fixed-effects model meta-analysis shows that the teaching of coding significantly improves problem-solving with the highest effect (dppc2 = 0.89), but also planning (dppc2 = 0.36), and inhibition and working memory with lower effects (dppc2 = 0.17, dppc2 = 0.20)

Faculty and Student Online Mentoring Preferences

Isolation of online doctoral students intensifies when they transition from coursework to the dissertation/capstone phase, limiting them to interacting with their mentors. A three-round modified Delphi study was conducted to examine mentoring preferences of online doctoral students and faculty. The first round provided qualitative data regarding the preferred mentoring practices for faculty and alumni. Round 1 qualitative data were organized into Likert questions and used in the second round, which resulted in data about frequency of mentoring practices for the same participants from Round 1. The third round provided data about importance of each preference rated by faculty and current students. Findings indicated a dichotomy was present in that mentees’ academic self-esteem appeared to be tied to faculty being responsive. Faculty emphasized mentee autonomy while mentees wanted frequent contact with faculty

Manual para construir toda especie de relojes de sol

Ilustrado con 28 grabados intercalados en el texto para su mayor comprensiónCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

Título: Segundo tratado de los reloxes solares

Port. con grab. xil., representando al autor.Texto con apostillas marginales.Il. son xil., algunas a toda plana.Copia digital : Junta de Castilla y León. Consejería de Cultura y Turismo, 2014Sign.: []2, A-2A6, 2B4, 2C1

Quilatador de oro, plata y piedras

Según Palau impreso en Madrid : por Guillermo Drouy, 1598Sign.: 2[calderón]\p8\s, A-Z\p8\s, 2A-2F\p8\s, 2G\p2\

Varia commesuración para la escultura y arquitectura

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200