Sexually Transmitted Infections and Sexual Behaviour Among Commercial Sex Workers in a Rural District of Malawi.

In Thyolo District, Malawi, a study was conducted among commercial sex workers (CSWs) attending mobile clinics in order to; determine the prevalence and pattern of sexually transmitted infections (STIs), describe sexual behaviour among those who have an STI and identify risk factors associated with 'no condom use'. There were 1817 CSWs, of whom 448 (25%) had an STI. Of these, the commonest infections included 237 (53%) cases of abnormal vaginal discharge, 109 (24%) cases of pelvic inflammatory disease and 95 (21%) cases of genital ulcer disease (GUD). Eighty-seven per cent had sex while symptomatic, 17% without condoms. Having unprotected sex was associated with being married, being involved with commercial sex outside a known rest-house or bar, having a GUD, having fewer than two clients/day, alcohol intake and having had no prior medication for STI. The high levels of STIs, particularly GUDs, and unprotected sex underlines the importance of developing targeted interventions for CSWs and their clients

Reconstructing emission from pre-reionization sources with cosmic infrared background fluctuation measurements by the JWST

We present new methodology to use cosmic infrared background (CIB) fluctuations to probe sources at 10<z<30 from a JWST/NIRCam configuration that will isolate known galaxies to 28 AB mag at 0.5--5 micron. At present significant mutually consistent source-subtracted CIB fluctuations have been identified in the Spitzer and Akari data at 2--5 micron, but we demonstrate internal inconsistencies at shorter wavelengths in the recent CIBER data. We evaluate CIB contributions from remaining galaxies and show that the bulk of the high-z sources will be in the confusion noise of the NIRCam beam, requiring CIB studies. The accurate measurement of the angular spectrum of the fluctuations and probing the dependence of its clustering component on the remaining shot noise power would discriminate between the various currently proposed models for their origin and probe the flux distribution of its sources. We show that the contribution to CIB fluctuations from remaining galaxies is large at visible wavelengths for the current instruments precluding probing the putative Lyman-break of the CIB fluctuations. We demonstrate that with the proposed JWST configuration such measurements will enable probing the Lyman break. We develop a Lyman-break tomography method to use the NIRCam wavelength coverage to identify or constrain, via the adjacent two-band subtraction, the history of emissions over 10<z<30 as the Universe comes out of the 'Dark Ages'. We apply the proposed tomography to the current Spitzer/IRAC measurements at 3.6 and 4.5 micron, to find that it already leads to interestingly low upper limit on emissions at z>30.Comment: ApJ, in press. Minor revisions/additions to match the version in proof

Solutions of the Klein-Gordon equation on manifolds with variable geometry including dimensional reduction

We develop the recent proposal to use dimensional reduction from the four-dimensional space-time D=(1+3) to the variant with a smaller number of space dimensions D=(1+d), d < 3, at sufficiently small distances to construct a renormalizable quantum field theory. We study the Klein-Gordon equation on a few toy examples ("educational toys") of a space-time with variable special geometry, including a transition to a dimensional reduction. The examples considered contain a combination of two regions with a simple geometry (two-dimensional cylindrical surfaces with different radii) connected by a transition region. The new technique of transforming the study of solutions of the Klein-Gordon problem on a space with variable geometry into solution of a one-dimensional stationary Schr\"odinger-type equation with potential generated by this variation is useful. We draw the following conclusions: (1) The signal related to the degree of freedom specific to the higher-dimensional part does not penetrate into the smaller-dimensional part because of an inertial force inevitably arising in the transition region (this is the centrifugal force in our models). (2) The specific spectrum of scalar excitations resembles the spectrum of the real particles; it reflects the geometry of the transition region and represents its "fingerprints". (3) The parity violation due to the asymmetric character of the construction of our models could be related to violation of the CP symmetry.Comment: laTeX file, 9 pages, 8 figures. Significant corrections in the title, abstract, text. Corrected formulas and figures. Added new references, amendments in English. Acceptred for publication in Theoretical and Mathematical Physics. To appear in vol. 167, may 201

Dichotomous Hamiltonians with Unbounded Entries and Solutions of Riccati Equations

An operator Riccati equation from systems theory is considered in the case that all entries of the associated Hamiltonian are unbounded. Using a certain dichotomy property of the Hamiltonian and its symmetry with respect to two different indefinite inner products, we prove the existence of nonnegative and nonpositive solutions of the Riccati equation. Moreover, conditions for the boundedness and uniqueness of these solutions are established.Comment: 31 pages, 3 figures; proof of uniqueness of solutions added; to appear in Journal of Evolution Equation

Voluntary Counselling, HIV Testing and Adjunctive Cotrimoxazole Reduces Mortality in Tuberculosis Patients in Thyolo, Malawi.

OBJECTIVES: To assess the feasibility and effectiveness of voluntary counselling, HIV testing and adjunctive cotrimoxazole in reducing mortality in a cohort of tuberculosis (TB) patients registered under routine programme conditions in a rural district of Malawi. DESIGN: 'Before' and 'after' cohort study using historical controls. METHODS: Between 1 July 1999 and 30 June 2000 all TB patients were started on standardized anti-TB treatment, and offered voluntary counselling and HIV testing (VCT). Those found to be HIV-positive were offered cotrimoxazole at a dose of 480 mg twice daily, provided there were no contraindications. Side-effects were monitored clinically. End-of-treatment outcomes in this cohort (intervention group) were compared with a cohort registered between 1 July 1998 and 30 June 1999 in whom VCT and cotrimoxazole was not offered (control group). FINDINGS: A total of 1986 patients was registered in the study: 1061 in the intervention group and 925 in the control cohort. In the intervention group, 1019 (96%) patients were counselled pre-test, 964 (91%) underwent HIV testing and 938 (88%) were counselled post-test. The overall HIV-seroprevalence rate was 77%. A total of 693 patients were given cotrimoxazole of whom 14 (2%) manifested minor dermatological reactions. The adjusted relative risk of death in the intervention group compared with the control group was 0.81 (P < 0.001). The number needed to treat with VCT and adjunctive cotrimoxazole to prevent one death during anti-TB treatment was 12.5. INTERPRETATION: This study shows that VCT and adjunctive cotrimoxazole is feasible, safe and reduces mortality rates in TB patients under routine programme conditions

Low level of virological failure and drug resistance among patients receiving antiretroviral treatment under programme conditions in Maputo, Mozambique

Mexico AIDS Conference 200

Constraints on the Progenitor of SN 2010jl and Pre-Existing Hot Dust in its Surrounding Medium

A search for the progenitor of SN~2010jl, an unusually luminous core-collapse supernova of Type~IIn, using pre-explosion {\it Hubble}/WFPC2 and {\it Spitzer}/IRAC images of the region, yielded upper limits on the UV and near-infrared (IR) fluxes from any candidate star. These upper limits constrain the luminosity and effective temperature of the progenitor, the mass of any preexisting dust in its surrounding circumstellar medium (CSM), and dust proximity to the star. A {\it lower} limit on the CSM dust mass is required to hide a luminous progenitor from detection by {\it Hubble}. {\it Upper} limits on the CSM dust mass and constraints on its proximity to the star are set by requiring that the absorbed and reradiated IR emission not exceed the IRAC upper limits. Using the combined extinction-IR emission constraints we present viable $M_d-R_1$ combinations, where $M_d$ and $R_1$ are the CSM dust mass and its inner radius. These depend on the CSM outer radius, dust composition and grain size, and the properties of the progenitor. The results constrain the pre-supernova evolution of the progenitor, and the nature and origin of the observed post-explosion IR emission from SN~2010jl. In particular, an $\eta$~Car-type progenitor will require at least 4~mag of visual extinction to avoid detection by the {\it Hubble}. This can be achieved with dust masses $\gtrsim 10^{-3}$~\msun\ (less than the estimated 0.2-0.5~\msun\ around $\eta$~Car) which must be located at distances of $\gtrsim 10^{16}$~cm from the star to avoid detection by {\it Spitzer}.Comment: Accepted for publication in the ApJ. 14 pages 10 figures. The complete figure set for Figure 10 (24 images) is available in the online journa

Well-Posedness and Symmetries of Strongly Coupled Network Equations

We consider a diffusion process on the edges of a finite network and allow for feedback effects between different, possibly non-adjacent edges. This generalizes the setting that is common in the literature, where the only considered interactions take place at the boundary, i. e., in the nodes of the network. We discuss well-posedness of the associated initial value problem as well as contractivity and positivity properties of its solutions. Finally, we discuss qualitative properties that can be formulated in terms of invariance of linear subspaces of the state space, i. e., of symmetries of the associated physical system. Applications to a neurobiological model as well as to a system of linear Schroedinger equations on a quantum graph are discussed.Comment: 25 pages. Corrected typos and minor change

The Berry-Keating operator on L^2(\rz_>, x) and on compact quantum graphs with general self-adjoint realizations

The Berry-Keating operator H_{\mathrm{BK}}:= -\ui\hbar(x\frac{ \phantom{x}}{ x}+{1/2}) [M. V. Berry and J. P. Keating, SIAM Rev. 41 (1999) 236] governing the Schr\"odinger dynamics is discussed in the Hilbert space L^2(\rz_>, x) and on compact quantum graphs. It is proved that the spectrum of $H_{\mathrm{BK}}$ defined on L^2(\rz_>, x) is purely continuous and thus this quantization of $H_{\mathrm{BK}}$ cannot yield the hypothetical Hilbert-Polya operator possessing as eigenvalues the nontrivial zeros of the Riemann zeta function. A complete classification of all self-adjoint extensions of $H_{\mathrm{BK}}$ acting on compact quantum graphs is given together with the corresponding secular equation in form of a determinant whose zeros determine the discrete spectrum of $H_{\mathrm{BK}}$. In addition, an exact trace formula and the Weyl asymptotics of the eigenvalue counting function are derived. Furthermore, we introduce the "squared" Berry-Keating operator $H_{\mathrm{BK}}^2:= -x^2\frac{ ^2\phantom{x}}{ x^2}-2x\frac{ \phantom{x}}{ x}-{1/4}$ which is a special case of the Black-Scholes operator used in financial theory of option pricing. Again, all self-adjoint extensions, the corresponding secular equation, the trace formula and the Weyl asymptotics are derived for $H_{\mathrm{BK}}^2$ on compact quantum graphs. While the spectra of both $H_{\mathrm{BK}}$ and $H_{\mathrm{BK}}^2$ on any compact quantum graph are discrete, their Weyl asymptotics demonstrate that neither $H_{\mathrm{BK}}$ nor $H_{\mathrm{BK}}^2$ can yield as eigenvalues the nontrivial Riemann zeros. Some simple examples are worked out in detail.Comment: 33p

The mid-infrared colors of the interstellar medium and extended sources at the Galactic center

A mid-infrared (3.6–8 μm) survey of the Galactic center has been carried out with the IRAC instrument on the Spitzer Space Telescope. This survey covers the central 2º x 1.4º (~280 x 200 pc) of the Galaxy. At 3.6 and 4.5 μm the emission is dominated by stellar sources, the fainter ones merging into an unresolved background. At 5.8 and 8 μm the stellar sources are fainter, and large-scale diffuse emission from the ISM of the Galaxy's central molecular zone becomes prominent. The survey reveals that the 8-to-5.8 μm color of the ISM emission is highly uniform across the surveyed region. This uniform color is consistent with a flat extinction law and emission from polycyclic aromatic hydrocarbons (PAHs). Models indicate that this broadband color should not be expected to change if the incident radiation field heating the dust and PAHs is ~10^4 times that of the solar neighborhood. Other regions of very red emission indicate cases where thick dust clouds obscure deeply embedded objects or very early stages of star formation