Evidence for the emergence of dust-free stellar populations at z > 10

We present an analysis of the UV continuum slopes for a sample of $176$ galaxy candidates at $8 < z_{\mathrm{phot}} < 16$. Focusing primarily on a new sample of $125$ galaxies at $\langle z \rangle \simeq 11$ selected from $\simeq 320$ arcmin$^2$ of public JWST imaging data across $15$ independent datasets, we investigate the evolution of $\beta$ in the galaxy population at $z > 8$. In the redshift range $8 < z < 10$, we find evidence for a relationship between $\beta$ and $M_{\rm UV}$, such that galaxies with brighter UV luminosities display redder UV slopes, with $\rm{d}\beta/ \rm{d} M_{\rm UV} = -0.17 \pm 0.03$. A comparison with literature studies down to $z\simeq2$ suggests that a $\beta-M_{\rm UV}$ relation has been in place from at least $z\simeq10$, with a slope that does not evolve strongly with redshift, but with an evolving normalisation such that galaxies at higher redshifts become bluer at fixed $M_{\rm UV}$. We find a significant trend between $\beta$ and redshift, with the inverse-variance weighted mean value evolving from $\langle \beta \rangle = -2.17 \pm 0.05$ at $z = 9.5$ to $\langle \beta \rangle = -2.56 \pm 0.05$ at $z = 11.5$. Based on a comparison with stellar population models, we find that at $z>10.5$ the average UV continuum slope is consistent with the intrinsic blue limit of `dust-free' stellar populations $(\beta_{\mathrm{int}} \simeq -2.6)$. These results suggest that the moderately dust-reddened galaxy population at $z < 10$ was essentially dust free at $z \simeq 11$. The extremely blue galaxies being uncovered at $z>10$ place important constraints on the dust content of early galaxies, and imply that the already observed galaxy population is likely supplying an ionizing photon budget capable of maintaining ionized IGM fractions of $\gtrsim 5$ per cent at $z\simeq11$.Comment: 16 pages, 12 figures, submitted to MNRA

New quantitative nitrogen abundance estimations in a sample of Seyfert 2 active galactic nuclei

We obtained new quantitative determinations of the nitrogen abundance and a consistent relation between the nitrogen and oxygen abundances for a sample of Seyfert 2 galaxies located at redshift z < 0.1. We carried out this analysis using the CLOUDY code to build detailed photoionization models. We were able to reproduce observed optical narrow emission line intensities for 44 sources compiled from the literature. Our results show that Seyfert 2 nuclei have nitrogen abundances ranging from ∼0.3 to ∼7.5 times the solar value. We derived the relation log (N/H) = 1.05( ± 0.09) × [log (O/H)] − 0.35( ± 0.33). Results for N/O versus O/H abundance ratios derived for Seyfert 2 galaxies are in consonance with those recently derived for a sample of extragalactic disc H II regions with high metallicity.Instituto de Astrofísica de La PlataFacultad de Ciencias Astronómicas y Geofísica

The COS Legacy Archive Spectroscopy Survey (CLASSY) Treasury Atlas

Abstract Far-ultraviolet (FUV; ∼1200–2000 Å) spectra are fundamental to our understanding of star-forming galaxies, providing a unique window on massive stellar populations, chemical evolution, feedback processes, and reionization. The launch of the James Webb Space Telescope will soon usher in a new era, pushing the UV spectroscopic frontier to higher redshifts than ever before; however, its success hinges on a comprehensive understanding of the massive star populations and gas conditions that power the observed UV spectral features. This requires a level of detail that is only possible with a combination of ample wavelength coverage, signal-to-noise, spectral-resolution, and sample diversity that has not yet been achieved by any FUV spectral database. We present the Cosmic Origins Spectrograph Legacy Spectroscopic Survey (CLASSY) treasury and its first high-level science product, the CLASSY atlas. CLASSY builds on the Hubble Space Telescope (HST) archive to construct the first high-quality (S/N1500 Å ≳ 5/resel), high-resolution (R ∼ 15,000) FUV spectral database of 45 nearby (0.002 &lt; z &lt; 0.182) star-forming galaxies. The CLASSY atlas, available to the public via the CLASSY website, is the result of optimally extracting and coadding 170 archival+new spectra from 312 orbits of HST observations. The CLASSY sample covers a broad range of properties including stellar mass (6.2 &lt; log M ⋆(M ⊙) &lt; 10.1), star formation rate (−2.0 &lt; log SFR (M ⊙ yr−1) &lt; +1.6), direct gas-phase metallicity (7.0 &lt; 12+log(O/H) &lt; 8.8), ionization (0.5 &lt; O32 &lt; 38.0), reddening (0.02 &lt; E(B − V) &lt; 0.67), and nebular density (10 &lt; n e (cm−3) &lt; 1120). CLASSY is biased to UV-bright star-forming galaxies, resulting in a sample that is consistent with the z ∼ 0 mass–metallicity relationship, but is offset to higher star formation rates by roughly 2 dex, similar to z ≳ 2 galaxies. This unique set of properties makes the CLASSY atlas the benchmark training set for star-forming galaxies across cosmic time

A loss-of-function splice acceptor variant in IGF2 is protective for type 2 diabetes

Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2D and 12,966 individuals without T2D of Latino descent. We identified a novel genetic variant in the IGF2 gene associated with ∼20% reduced risk for T2D. This variant, which has an allele frequency of 17% in the Mexican population but is rare in Europe, prevents splicing between IGF2 exons 1 and 2. We show in vitro and in human liver and adipose tissue that the variant is associated with a specific, allele-dosage–dependent reduction in the expression of IGF2 isoform 2. In individuals who do not carry the protective allele, expression of IGF2 isoform 2 in adipose is positively correlated with both incidence of T2D and increased plasma glycated hemoglobin in individuals without T2D, providing support that the protective effects are mediated by reductions in IGF2 isoform 2. Broad phenotypic examination of carriers of the protective variant revealed no association with other disease states or impaired reproductive health. These findings suggest that reducing IGF2 isoform 2 expression in relevant tissues has potential as a new therapeutic strategy for T2D, even beyond the Latin American population, with no major adverse effects on health or reproduction