Impact of Sodium Layer variations on the performance of the E-ELT MCAO module

Multi-Conjugate Adaptive Optics systems based on sodium Laser Guide Stars may exploit Natural Guide Stars to solve intrinsic limitations of artificial beacons (tip-tilt indetermination and anisoplanatism) and to mitigate the impact of the sodium layer structure and variability. The sodium layer may also have transverse structures leading to differential effects among Laser Guide Stars. Starting from the analysis of the input perturbations related to the Sodium Layer variability, modeled directly on measured sodium layer profiles, we analyze, through a simplified end-to-end simulation code, the impact of the low/medium orders induced on global performance of the European Extremely Large Telescope Multi-Conjugate Adaptive Optics module MAORY.Comment: 7 pages, 5 figures, SPIE conference Proceedin

Applying Lean to Healthcare Delivery Processes - a Case-based Research

The purpose of this paper is to demonstrate that Lean principles and methodology should be applied on a regular basis to the entire process flow of healthcare delivery systems. With reference to an actual case-based research, this article demonstrates how patient flows can be successfully optimized if Lean is not limited to single processes/contexts only, and it is applied to achieve holistic process improvement of an entire system. The complexity of healthcare delivery systems requires inclusive investigation from various points of view. This is why case-study-based research has been used to investigate dynamic, experiential and complex processes and areas, such as the ones featured by this article. The methodological basis for this research has been a twelve-step optimization approach outlined by the authors during a previous successful Lean programme. This same approach has been applied to optimize patient flows in the emergency departments of four different hospitals in Northern Italy. The research has involved teams composed of medical, nursing, technical and administrative staff.The results outlined in the article suggest that inclusive application of Lean tools leads to effective process optimization and a better working environment, when in connection with a systematic and holistic optimization approach. Feedback from participants was obtained through a satisfaction survey and a project assessment; it reported enthusiastic project acceptance and good teamwork climate. Among the results of the research performed in the four hospitals, several measures have been effectively implemented to reduce the lead-time for patients from registration to discharge. At the same time, patient-staff ratio and quality of care have been either maintained or even improved. However, lack of a definite conclusive evaluation can be explained by the research project still being implemented.The value of this paper lies in demonstrating how Lean contributes to achieve better process performance and high staff satisfaction, when implemented within the whole supply chain of a healthcare delivery system on a regular basis

On the radio and NIR jet of PKS 2155-304 and its close environment

PKS 2155-304 is one of the brightest BL Lac object in the sky and a very well studied target from radio to TeV bands. We report on high-resolution (~ 0.12 arcsec) direct imaging of the field of PKS 2155-304 using adaptive optics near-IR observations in J and Ks bands obtained with the ESO multi-conjugate adaptive optic demonstrator (MAD) at the Very Large Telescope. These data are complemented with archival VLA images at various frequencies to investigate the properties of the close environment of the source. We characterized the faint galaxies that form the poor group associated to the target. No radio emission is present for these galaxies, while an old radio jet at ~ 20 kpc from the nucleus of PKS 2155-304 and a jet-like structure of ~ 2 kpc (~ 1 arcsec) in the eastern direction are revealed. No counterparts of these radio jets are found in the NIR or in archival Chandra observations.Comment: 10 pages, 7 figures, accepted for publication in The Astronomical Journa

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response.

Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis. Inherited gain-of-function mutations in RHBDF2 (encoding iRHOM2) are associated with a hyperproliferative palmoplantar keratoderma and squamous oesophageal cancer syndrome (termed TOC). In contrast, genetic ablation of rhbdf2 in mice leads to a thinning of the mammalian footpad, and reduces keratinocyte hyperproliferation and migration. Here, we report that iRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes. We demonstrate that p63-iRHOM2 regulates cell survival and response to oxidative stress via modulation of SURVIVIN and Cytoglobin, respectively. Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production. These findings elucidate a novel p63-associated pathway that identifies iRHOM2 modulation as a potential therapeutic target to treat hyperproliferative skin disease and neoplasia