Workmen's Compensation

Notes and Comment

Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification

Many compounds and genetic manipulations are claimed to confer resistance to obesity in rodents by raising energy expenditure. Examples taken from recent and older literature, demonstrate that such claims are often based on measurements of energy expenditure after body composition has changed, and depend on comparisons of energy expenditure divided by body weight. This is misleading because white adipose tissue has less influence than lean tissue on energy expenditure. Application of this approach to human data would suggest that human obesity is usually due to a low metabolic rate, which is not an accepted view. Increased energy expenditure per animal is a surer way of demonstrating thermogenesis, but even then it is important to know whether this is due to altered body composition (repartitioning), or increased locomotor activity rather than thermogenesis per se. Regression analysis offers other approaches. The thermogenic response to some compounds has a rapid onset and so cannot be due to altered body composition. These compounds usually mimic or activate the sympathetic nervous system. Thermogenesis occurs in, but may not be confined to, brown adipose tissue. It should not be assumed that weight loss in response to these treatments is due to thermogenesis unless there is a sustained increase in 24-h energy expenditure. Thyroid hormones and fibroblast growth factor 21 also raise energy expenditure before they affect body composition. Some treatments and genetic modifications alter the diurnal rhythm of energy expenditure. It is important to establish whether this is due to altered locomotor activity or efficiency of locomotion. There are no good examples of compounds that do not affect short-term energy expenditure but have a delayed effect. How and under what conditions a genetic modification or compound increases energy expenditure influences the decision on whether to seek drugs for the target or take a candidate drug into clinical studie

Urban Design of Bristol Waterfront, Lower Thames Street

Collaboration with the Town of Bristol in the fall of 2013 when students in ARCH 415, Advanced Design Studio – Urban, under the guidance of Professor Ulker Copur, studied the waterfront area along the west side of Thames Street, from State Street south to the armory in Bristol, Rhode Island, including the continuation of a public boardwalk through the area linking up with the adjacent properties. The designs created by students would be used to guide the town in developing a master plan for the area and the new Bristol Maritime Welcome Center

Landscape and City during Fascism: Enrico del Debbio’s Foro Mussolini

Beiträge zum Symposium „Urban design and dictatorship in the 20th century: Italy, Portugal, the Soviet Union, Spain and Germany. History and Historiography“. Weimar, 21.-22. November 2013For decades in Germany, historical research on dictatorial urban design in the first half of the 20th century focused on the National Socialist period. Studies on the urban design practices of other dictatorships remained an exception. This has changed. Meanwhile, the urban production practices of the Mussolini, Stalin, Salazar, Hitler and Franco dictatorships have become the subject of comprehensive research projects. Recently, a research group that studies dictatorial urban design in 20th century Europe has emerged at the Bauhaus-Institut für Geschichte und Theorie der Architektur und der Planung. The group is already able to refer to various research results. Part of the research group’s self-conception is the assumption that the urban design practices of the named dictatorships can only be properly understood from a European perspective. The dictatorships influenced one another substantially. Furthermore, the specificities of the practices of each dictatorship can only be discerned if one can compare them to those of the other dictatorships. This approach requires strict adherence to the research methods of planning history and urban design theory. Meanwhile, these methods must be opened to include those of general historical studies. With this symposium, the research group aims to further qualify this European perspective. The aim is to pursue an inventory of the various national historiographies on the topic of “urban design and dictatorship”. This inventory should offer an overview on the general national level of historical research on urban design as well as on the level of particular urban design projects, persons or topics. The symposium took place in Weimar, November 21-22, 2013. It was organized by Harald Bodenschatz, Piero Sassi and Max Welch Guerra and funded by the DAAD (German Academic Exchange Service)