Rotura no traumática de componente cerámica-cerámica en PTC: presentación de un caso y revisión de la literatura.

Las fracturas de los componentes cerámicos empleados en artroplastia total de cadera (ATC) son infrecuentes. El objetivo de nuestro trabajo es presentar un caso de rotura precoz no traumática de componente ce - rámica-cerámica en ATC y revisar la literatura en relación con esta complicación. Se trata de un paciente de 58 años diagnosticado de necrosis avascular de cabeza femoral, fue intervenido mediante ATC, implantándosele un par cerámica-cerámica. A los 4 meses de la intervención, sin antecedente traumático previo, se observó fractura de la cúpula de cerámica de la prótesis. El paciente precisó de recambio protésico, utilizándose el par cerámica-polietileno. La fractura de los componentes del par cerámica- cerámica es poco frecuente. El fallo puede ser debido a un defecto de fabricación o en la colocación del implante. Los pacientes deben ser informados sobre la posibilidad de sufrir esta complicación antes de la implantación de una PTC con par cerámica-cerámica.Fractures of ceramic components used in total hip replacement (THR) are uncommon. To report a case of early non-traumatic rupture ceramic-ceramic component in THR and review the literature regarding this complication. A 58 years diagnosed with avascular necrosis of the femoral head, was operated by THR, a ceramic-on -ceramic. At 4 months after surgery, without previous trauma, fracture was observed ceramic dome of the prosthesis. The patient required replacement, using the ceramic-on-polyethylene. The fracture of ceramic components is rare. The failure may be due to a manufacturing defect or implant placement. Patients should be informed about the possi - bility of having this complication before implantation of a THR ceramic-on-ceramic

An asymmetric BODIPY triad with panchromatic absorption for high-performance red-edge laser emission

© The Royal Society of Chemistry 2015. A rational design of an unprecedented asymmetric cassette triad based entirely on BODIPY chromophores allows efficient light harvesting over the UV-vis spectral region, leading to a bright and stable red-edge laser emission via efficient energy-transfer processes.Peer Reviewe

Unprecedented J-Aggregated Dyes in Pure Organic Solvents

We describe the design and synthesis of the first organic dyes enabling spontaneous formation of stable J-aggregates in common organic solvents without additives. The new dyes are O-BODIPYs with a B-spiranic 4,4-diacyloxyl substitution pattern. Key to the effectiveness of the J-aggregation process is the high conformational rigidity of the Bspiranic molecular design as well as the orthogonal disposition of the B-diacyloxyl substituent and the meso-aryl group with respect to the mean plane of the borodiazaindacene. Atomistic simulations, both in vacuum and in a solvent cage, support the dynamics of the J-aggregation process as well as its dependence on the alkylation pattern of the BODIPY chromophore. A detailed analysis of the photophysical and laser properties of the new dyes provides convincing evidence for the unambiguous assignment of these J-aggregates and their dependence on the environmental conditions.We gratefully acknowledge financial support by the Spanish Ministerio de Economia y Competitividad (projects MAT2014-51937-C3-1-P, MAT2014- 51937-C3-2-P, MAT2014-51937-C3-3-P, and MAT2015-68837-REDT). I. E. thanks the Gobierno Vasco (IT339-10) for a predoctoral contract. H. M. acknowledges the Spanish Ministerio de Economia y Competitividad for a Juan de la Cierva postdoctoral contract. The authors thank SGIker of UPV/EHU for technical and human support with the X-ray diffraction measurements and computational calculations, which were carried out in the “arina” informatic cluster. We also thank Diego Plaza Lozano for preliminary synthetic studies.Peer reviewe

Modulation of host cell processes by T3SS effectors

Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target-the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection

8-phenyl-substituted dipyrromethene center dot BF2 complexes as highly efficient and photostable laser dyes

We report oil the synthesis and the photophysical and lasing properties of two new dipyrromethene.BF2, dyes. analogues of the commercial dye PM567, dissolved in liquid solutions or ill polymeric matrices of poly(methyl methacrylate) and as solid copolymers with methyl methacrylate, where the chromophore is covalently bound to the polymeric chains. The new dyes have the 8 position substituted by the group p-(acetoxypolymetlylene)phenyl or p-(methacryloyloxypolymethylene)phenyl (number of methylenes = 1 or 3). Good correlations between the photophysical properties in dilute solutions and the lasing characteristics ill moderately concentrated solutions have been observed. The presence of the 8-phenyl substituent does not significantly modify the photophysics of the chromophore. Theoretical calculations were performed to rationalize this behavior. Under transversal pumping at 534 nm, laser efficiencies up to 46% were obtained for liquid Solutions, which were found to be nearly independent of the nature of the solvent and the length of the polymethylene chain. For solid samples, lasing efficiencies of up to 23% and good photostabilities, With 96% of the initial laser Output after 100 000 PUMP pulses at 10 Hz, were established.Peer reviewe

Singular laser behavior of hemicyanine dyes: Unsurpassed efficiency and finely structured spectrum in the near-IR region

In this paper we identify the origin of a novel and singular laser behavior of the hemicyanine dye LDS 722 transversally pumped at 532 nm. With lasing efficiencies as high as 43%, in spite of the fluorescence quantum yields being as low as 0.075, the laser spectra exhibit a finely structured spectral profile, with a periodic modulation with peak separation 0.4 nm, not related to mode selection due to spatial or spectral hole burning. The correlation of the LDS 722 lasing behavior as a function of both environmental properties (polarity, viscosity, protic character of the solvent) and pumping conditions (cavity configuration, pump geometry and energy) with its photophysical properties provides inklings to understand the physics responsible for the peculiar laser behavior in these rather complex dyes.Peer Reviewe

Synthesis and optical and redox properties of symmetric and asymmetric BODIPYs

Peer Reviewe

A FRET analysis of dye diffusion in core/shell polymer nanoparticles

In this paper we show that dye distributions within polymer core/shell nanoparticles (NPs), grown in multiple steps, are controlled not only by the synthesis route, but are also governed by dye diffusion between core and shell, resulting in dye distributions completely different from the targeted ones. We show that Förster Resonance Energy Transfer (FRET) dynamics can be used as a spectroscopic measure to determine the particular dye profiles along the NPs and thus to uncover the presence of dye diffusion. Finally, to confirm the previous results and with the aim to have a clearer understanding of the diffusion processes within core/shell NPs (equilibrium and transient dye distributions, time scales, etcetera), we analyze the behaviour predicted by existing diffusion models and infer that the dye diffusion is already finished at the end of the shell growth. This journal is © the Partner Organisations 2014.Peer Reviewe