Recommendations for safe dental care : A systematic review of clinical practice guidelines in the first year of the covid-19 pandemic

Altres ajuts: Agencia Nacional de Investigation y Desarrollo (ANID), Chile (COVID0700).In the context of a pandemic, the rapid development of clinical practice guidelines (CPGs) is critical to guide dental staff towards the safe provision of dental care; detailed knowledge of the recommendations will help to achieve the intended results. We carried out a systematic review of the recommendations in clinical practice guidelines (CPGs) on the provision of dental care issued during the first year of the COVID-19 pandemic. A systematic database search was performed in MEDLINE, EMBASE, LILACS, Epistemonikos, and Trip databases to identify documents with recommendations intended to minimize the risk of COVID-19 transmission during dental care. The selection process and data extraction were carried out by two researchers independently. The majority of CPGs recommended the use of rubber dam, high-volume evacuator, mouthwash prior to dental care, four-handed work, and mechanical barriers. The use of aerosol-generating equipment should be avoided whenever possible. In aerosol-generating procedures, the use of a N95 respirator (or similar) is recommended, in addition to a face protector, an impermeable disposable apron/gown, a cap, and gloves. The CPGs developed during the first year of the pandemic offer recommendations which guide dental staff in providing safe dental care, minimizing exposure to SARS-CoV-2 and reducing the risk of COVID-19 infection in the clinical environment. Such recommendations must, however, be updated as new evidence arises

Quality appraisal of clinical practice guidelines on provision of dental services during the first months of the COVID-19 pandemic

Objectives: To evaluate the quality of clinical practice guidelines (CPGs) on dental services provision during the first months of the COVID-19 pandemic. Materials and methods: We systematically searched in MEDLINE, EMBASE, LILACS, Epistemonikos, Trip databases, websites of CPG developers, compilers of CPGs, scientific societies and ministries of health to identify documents with recommendations intended to minimize the risk of COVID-19 transmission during dental care. Reviewers independently and in duplicate assessed the included CPGs using the AGREE II instrument. We calculated the standardized scores for the 6 domains and made a final recommendation about each CPG. The inter-appraiser agreement was assessed using the intraclass correlation coefficient (ICC). Results: Twenty-three CPGs published were included. Most of the CPGs were from America (n = 15) and Europe (n = 6). The overall agreement between reviewers was very good (ICC = 0.93; 95%CI 0.87-0.95). The median score for each domain was the following: Scope and purpose 67% (IQR 20%); Stakeholder involvement 33% (IQR 14%); Rigour of development 13% (IQR 13%); Clarity of presentation 64% (IQR 31%); Applicability 19% (IQR 17%) and Editorial independence 8% (IQR 8%). Twenty two guidelines were not recommended by the reviewers. Only one of the CPGs was recommended with modifications. The median overall rate was 3 (IQR 1). All CPGs were classified as low quality. Conclusions: The overall quality of CPGs on dental services provision during the first months of the COVID-19 pandemic was low, which makes its implementation difficult for clinicians and policy makers. Therefore, it is critical that developers are transparent and forthcoming about the difficulties that have arisen during the CPG development process

Allende vive 30 años

El Seminario Internacional 30 Años Allende Vive, convocado por la Revista América Libre, el Centro de Educación Popular, CEPIS, de Brasil, el Centro Martín Luther King de Cuba y el ICAL, en un momento en que las luchas populares retoman la iniciativa, se planteó rescatar la memoria del proceso de la Unidad Popular y del ejemplo de Salvador Allende y proyectarla a las búsquedas que los movimientos populares realizan para construir alternativas al neoliberalismo, la emergencia de nuevos gobiernos populares, los caminos de creación de poder popular, la perspectiva socialista como proyecto y como opción. La publicación del seminario 30 Años Allende Vive constituye un aporte para la reflexión de la izquierda latinoamericana, y una importante fuente de consulta tanto para referencias históricas como para los muy actuales debates sobre la construcción de alternativas de cambio con perspectiva socialista.Presentación; Discurso de Inauguración del Seminario Internacional 30 Años, Allende Vive; Inauguración del Seminario 30 Años, Allende Vive; Saludos; Transformaciones de Estructura y Redistribución del Ingreso; La educación y la cultura en el Gobierno Popular; Reforma Agraria y Soberanía Alimentaria; Los logros de la Unidad Popular y las perspectivas en diferentes sectores sociales; Soberanía sobre los Recursos Naturales. El Cobre; El programa de gobierno de Salvador Allende; La Verdad sobre la Unidad Popular y el Golpe de Estado; Unidad Popular, Impacto y Solidaridad Internacional; Presentación del libro Salvador Allende, Textos Escogidos; La política imperialista. El ALCA y la militarización del mundo. El Plan Colombia; La unidad de los pueblos contra la estrategia imperialista, guerrerista, desestabilizadora y golpista de Estados Unidos; Ponencia de las Fuerzas Armadas Revolucionarias de Colombia Ejército del Pueblo (FARC-EP); Los cristianos en la lucha por el socialismo; Fuerzas Armadas, Democracia y Soberanía Nacional; Situación del movimiento sindical antes y después del golpe; Derechos Humanos antes y después del golpe de estado; Movimientos GLBTT y Procesos Revolucionarios en América Latina. Construyendo el nuevo sujeto histórico; Políticas de Género de la Izquierda Latinoamericana; Panel sobre Medios de comunicación; Gobernar la revolución. Por una gobernabilidad revolucionaria para la revolución bolivariana; La integración latinoamericana y el sueño bolivariano; Las alternativas populares en América Latina ayer y hoy. Izquierda e Institucionalidad, Reforma y Revolución; Los movimientos sociales y los partidos políticos en la construcción de las alternativas populares. Sujeto histórico, alianzas, programas, estrategias; La perspectiva socialista en la construcción de las alternativas populare

Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity

Chagas disease, caused by Trypanosoma cruzi parasite, was described thousands of years ago. Currently, it affects millions of people, mostly in Latin America, and there are not suitable drugs for treating it. As an attempt to find appropriate drugs to deal with this problem, we report here on the design, synthesis and characterization of eighty-two new compounds. Trypanosomicidal behavior in vitro showed more than twenty outstanding derivatives with anti-Trypanosoma cruzi activity. Furthermore, we studied the nonspecific toxicity against mammalian cells determining their selectivity and also performed mutagenicity studies. Proof of concept, in vivo studies, was conducted with two of the most promising derivatives (77 and 80). They were identified as candidates because they have: (i) very simple and cost-effective syntheses; (ii) activity against different stages and strains of the parasite showing excellent in vivo behavior during the acute phase of Chagas disease; (iii) neither nonspecific toxicity nor mutagenic activity.Fil: Guzmán Álvarez, Javier Varela. Universidad de la República; UruguayFil: Varela, Javier. Universidad de la República; UruguayFil: Márquez, Pablo. Universidad de la República; UruguayFil: Gabay, Martín. Universidad de la República; UruguayFil: Arias Rivas, Carmen Elena. Centro Nacional de Investigaciones Científicas; El SalvadorFil: Cuchilla, Karina. Centro Nacional de Investigaciones Científicas; El SalvadorFil: Echeverría, Gustavo Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Piro, Oscar Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Chorilli, Marlus. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Leal, Sandra M.. Universidad Industrial Santander; ColombiaFil: Escobar, Patricia. Universidad Industrial Santander; ColombiaFil: Serna, Elva. Universidad Nacional de Asunción; ParaguayFil: Torres, Susana. Universidad Nacional de Asunción; ParaguayFil: Yaluff, Gloria. Universidad Nacional de Asunción; ParaguayFil: Vera de Bilbao, Ninfa I.. Universidad Nacional de Asunción; ParaguayFil: González, Mercedes. Universidad de la República; UruguayFil: Cerecetto, Hugo. Universidad de la República; Urugua