What Sexual Minorities in Adulthood Want for the Present School Education

　本研究の目的は，カミングアウトが難しい性的マイノリティ当事者が学校教育にどのような支援を望んでいるのか明らかにすることである。方法として質問紙調査を行った。質問紙作成にあたり，当事者への学校での支援について文献検索を行い，主に授業外で取り組む支援例を収集した。収集した支援例の評価を当事者18 名に依頼した。学校教育に求めていることは，相談してきた児童生徒の気持ちに寄り添うこと，第三者に知られないよう配慮すること，性の多様性と正しい知識を教えることであった。また，「開示しようとしまいと，いることを前提とする」学校になってほしいと希望していることが伺えた。教員は性的マイノリティの児童生徒が抱える困難さを重要な課題と捉え，いつでも誰でも相談できる環境づくりや，児童生徒の気持ちを尊重する努力が必要とされていると考える

Prevention of hypoglycemia by intermittent-scanning continuous glucose monitoring device combined with structured education in patients with type 1 diabetes mellitus : A randomized, crossover trial

Aims: We conducted a randomized, crossover trial to compare intermittent-scanning continuous glucose monitoring (isCGM) device with structured education (Intervention) to self-monitoring of blood glucose (SMBG) (Control) in the reduction of time below range. Methods: This crossover trial involved 104 adults with type 1 diabetes mellitus (T1DM) using multiple daily injections. Participants were randomly allocated to either sequence Intervention/Control or sequence Control/Intervention. During the Intervention period which lasted 84 days, participants used the first-generation FreeStyle Libre (Abbott Diabetes Care, Alameda, CA, USA) and received structured education on how to prevent hypoglycemia based on the trend arrow and by frequent sensor scanning (≥10 times a day). Confirmatory SMBG was conducted before dosing insulin. The Control period lasted 84 days. The primary endpoint was the decrease in the time below range (TBR; <70 mg/dL). Results: The time below range was significantly reduced in the Intervention arm compared to the Control arm (2.42 ± 1.68 h/day [10.1 %±7.0 %] vs 3.10 ± 2.28 h/day [12.9 %±9.5 %], P = 0.012). The ratio of high-risk participants with low blood glucose index >5 was significantly reduced (8.6 % vs 23.7 %, P < 0.001). Conclusions: The use of isCGM combined with structured education significantly reduced the time below range in patients with T1DM

地域活動を“いきいき”として支えている人の要因

本研究の目的は、地域活動を“いきいき”として支えている人の要因を明らかにし、どうしたらそのような人を増やせるのかを検討することである。地域に住み、地域において“いきいき”とボランティアや役員として活動している13名を対象に、半構成的インタビューを行った。KJ法を用いて分類・図解した結果、“いきいき”と活動を続けられる要因は「いきいきと活動するサイクル」と「支援するサイクル」の2つに分けられ、「いきいきと活動するサイクル」を回すためには「支援するサイクル」を円滑に回す事が必要であった。二つのサイクルが円滑に回り、地域活動を発展し続ける事で“いきいき”と活動する人が増えると考えられた

Heat Shock Factor 1 Contributes to Ischemia-Induced Angiogenesis by Regulating the Mobilization and Recruitment of Bone Marrow Stem/Progenitor Cells

Bone marrow (BM)-derived stem/progenitor cells play an important role in ischemia-induced angiogenesis in cardiovascular diseases. Heat shock factor 1 (HSF1) is known to be induced in response to hypoxia and ischemia. We examined whether HSF1 contributes to ischemia-induced angiogenesis through the mobilization and recruitment of BM-derived stem/progenitor cells using HSF1-knockout (KO) mice. After the induction of ischemia, blood flow and microvessel density in the ischemic hindlimb were significantly lower in the HSF1-KO mice than in the wild-type (WT) mice. The mobilization of BM-derived Sca-1- and c-kit-positive cells in peripheral blood after ischemia was significantly lower in the HSF1-KO mice than in the WT mice. BM stem/progenitor cells from HSF1-KO mice showed a significant decrease in their recruitment to ischemic tissue and in migration, adhesion, and survival when compared with WT mice. Blood flow recovery in the ischemic hindlimb significantly decreased in WT mice receiving BM reconstitution with donor cells from HSF1-KO mice. Conversely, blood flow recovery in the ischemic hindlimb significantly increased in HSF1-KO mice receiving BM reconstitution with donor cells from WT mice. These findings suggest that HSF1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of BM-derived stem/progenitor cells

What Sexual Minorities in Adulthood Want for the Present School Education

　本研究の目的は，カミングアウトが難しい性的マイノリティ当事者が学校教育にどのような支援を望んでいるのか明らかにすることである。方法として質問紙調査を行った。質問紙作成にあたり，当事者への学校での支援について文献検索を行い，主に授業外で取り組む支援例を収集した。収集した支援例の評価を当事者18 名に依頼した。学校教育に求めていることは，相談してきた児童生徒の気持ちに寄り添うこと，第三者に知られないよう配慮すること，性の多様性と正しい知識を教えることであった。また，「開示しようとしまいと，いることを前提とする」学校になってほしいと希望していることが伺えた。教員は性的マイノリティの児童生徒が抱える困難さを重要な課題と捉え，いつでも誰でも相談できる環境づくりや，児童生徒の気持ちを尊重する努力が必要とされていると考える

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

Abstract 2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown. The CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been established as an alternative to long-term studies (1.5 years—lifetime) to detect carcinogenicity in as short a time as six months. We performed a 26-week inhalation exposure study of 2-BP using the rasH2 mouse model. Male and female rasH2 mice were exposed to 0, 67, 200, or 600 ppm of 2-BP for 6 h/day, 5 days/week for 26 weeks. All tissues and blood were collected and subjected to biological and histopathological analyses. The results showed a concentration-dependent increase in lung tumor development in male and female rasH2 mice exposed by inhalation to 2-BP, which was significant by Peto’s and Poly-3 trend tests. Furthermore, in male rasH2 mice, 2-BP was found to be a testicular toxin. This study is the first to demonstrate that 2-BP is carcinogenic in male and female mice and a testicular toxin in male mice using the rasH2 mouse model

Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms

Becker muscular dystrophy (BMD) carriers are at risk to developing cardiac dysfunction. The prevalence of female BMD carriers remains underestimated, and the disease progression varies. We herein report the case of a young female BMD carrier who developed dilated cardiomyopathy (DCM) and heart failure without any skeletal muscle signs. Her cardiac dysfunction progressed over a mere two months, resulting in the need for left ventricular assist device implantation. Her case demonstrates that progressive cardiomyopathy can be the only clinical manifestation in some BMD carriers, suggesting the need for a more aggressive implementation of genetic testing in female DCM patients

POEMS Syndrome Showing Left Ventricular Dysfunction and Extracellular Edema Assessed by Cardiac Magnetic Resonance Imaging

Although cardiac involvement is rare in polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome, the clinical course becomes considerably worse on complication with cardiac lesions. The increased release of various cytokines has been observed in the pathogenesis of POEMS syndrome, and serum vascular endothelial growth factor (VEGF) levels are known to be associated with the disease activity. We herein report a patient with POEMS syndrome who showed left ventricular systolic dysfunction and was treated with lenalidmide therapy. Of note, the reduction in extracellular edema in the left ventricular wall was clearly visualized by changes in the native T1 values and extracellular volumes on cardiac magnetic resonance imaging