MSSM and Large tanβtan\beta from SUSY Trinification

We construct a supersymmetric model based on the semi-simple gauge group $SU(3)_c \times SU(3)_L \times SU(3)_R$ with the relation $tan\beta \simeq m_t/m_b$ automatically arising from its structure. The model below a scale $\sim 10^{16}$ GeV gives naturally rise just to the minimal supersymmetric standard model and therefore to the presently favored values for $sin^2 \theta_w$ and $\alpha_s$ without fields in representations higher than the fundamental.Comment: 9 pages, LaTeX, UT-STPD-3-9

A New Model for Fermion Masses in Supersymmetric Grand Unified Theories

We present a simple model for fermion mass matrices and quark mixing in the context of supersymmetric grand unified theories and show its agreement with experiment. Our model realizes the GUT mass relations $m_d=3m_e$, $m_s= m_\mu/3$, $m_b=m_\tau$ in a new way and is easily consistent with values of $m_t$ suggested by MSSM fits to LEP data.Comment: Latex, 8 p., ITP-SB-93-37 (revised version contains minor changes in some wording and citations; no changes in analytic or numerical results.

A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: To perform an exploratory analysis of the relative contribution of single MHC genes to the pathogenesis of systemic lupus erythematosus (SLE) in a homogenous white population. METHODS: MHC class II alleles and C4 allotypes were determined in 64 SLE patients and in ethnically matched controls. HLA-DR and DQ typing was performed by polymerase chain reaction amplification with sequence specific primers. C4 allotypes were determined by agarose gel electrophoresis. RESULTS: The frequency of C4A*Q0 was significantly higher in patients than in controls (46.9% v 25.3%, p = 0.002). HLA-DRB1, DQA1, and DQB1 alleles in the whole group of SLE patients were not significantly different from those of controls. On the other hand increase in DRB1*03 was observed in the group of patients with C4A*Q0, as compared with patients with other C4A allotypes (p = 0.047). There was no significant correlation between severe and mild disease, as judged by the SLEDAI, and HLADR, DQ alleles and comparing the patients with C4A*Q0 with those with other C4A allotypes there was no significant difference regarding clinical manifestations. CONCLUSION: The results are consistent with the argument that C4A deficiency contributes independently to susceptibility and the pathogenesis of SLE. C4A*Q0 in SLE patients in Iceland shows weaker linkage disequilibrium with DR3 genes than reported in most other white populations and emphasises the role of ethnicity

Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.

We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome 11. Three distinct regions of LOH were identified: 11p15.5, 11q13 and 11q22-qter with a LOH frequency of 19, 23 and 37-43% respectively. The marker D11S969 showing the highest frequency of LOH (43%) is located at the 11q24.1-q25 region. No previous molecular genetic studies have shown frequent LOH at the region telomeric to q23 on chromosome 11. Southern analysis revealed that LOH at 11q13 was due to amplification, whereas LOH at 11q22qter was due to deletion. LOH at 11p15.5 was associated with paucity of hormone receptor proteins, high S-phase and positive node status. An association was found between LOH at 11q13 and positive node status. LOH at the 11q22-qter region correlated with a high S-phase fraction. A significant association was found between LOH at 11p15 and chromosome regions 17q21 (the BRCA1 region) and 3p

Third Generation Effects on Fermion Mass Predictions in Supersymmetric Grand Unified Theories

Relations among fermion masses and mixing angles at the scale of grand unification are modified at lower energies by renormalization group running induced by gauge and Yukawa couplings. In supersymmetric theories, the $b$ quark and $\tau$ lepton Yukawa couplings, as well as the $t$ quark coupling, may cause significant running if $\tan \beta$, the ratio of Higgs field expectation values, is large. We present approximate analytic expressions for the scaling factors for fermion masses and CKM matrix elements induced by all three third generation Yukawa couplings. We then determine how running caused by the third generation of fermions affects the predictions arising from three possible forms for the Yukawa coupling matrices at the GUT scale: the Georgi-Jarlskog, Giudice, and Fritzsch textures.Comment: phyzzx, 26 pp., 6 figures not included, e-mailable upon request, JHU-TIPAC-93000

Predictions for Constrained Minimal Supersymmetry with Bottom-Tau Mass Unification

We examine the Constrained Minimal Supersymmetric Standard Model (CMSSM) with an additional requirement of strict b - tau unification in the region of small tan(beta). We find that the parameter space becomes completely limited below about 1 TeV by physical constraints alone, without a fine-tuning constraint. We study the resulting phenomenological consequences, and point out several ways of falsifying the adopted b - tau unification assumption. We also comment on the effect of a constraint from the non-observation of proton decay.Comment: Michigan preprint UM-TH-94-03, LaTeX, 18 pages with inline figures (figures included in uuencoded file). Complete PS file also available by anonymous FTP to williams.physics.lsa.umich.edu in /pub/preprints/UM-TH-94-03.ps.Z or by e-mailing reques

Hierarchy plus anarchy in quark masses and mixings

We introduce a new parameterisation of the effect of unknown corrections from new physics on quark and lepton mass matrices. This parameterisation is used in order to study how the hierarchies of quark masses and mixing angles are modified by random perturbations of the Yukawa matrices. We discuss several examples of flavour relations predicted by different textures, analysing how these relations are influenced by the random perturbations. We also comment on the unlikely possibility that unknown corrections contribute significantly to the hierarchy of masses and mixings.Comment: LaTeX, 18 pages, 16 PS figure

Test of the Dimopouos-Hall-Raby Ansatz for Fermion Mass Matrices

By evolution of fermion mass matrices of the Fritzsch and the Georgi-Jarlskog forms from the supersymmetric grand unified scale, DHR obtained predictions for the quark masses and mixings. Using Monte Carlo methods we test these predictions against the latest determinations of the mixings, the CP-violating parameter epsilon_K and the B_d^0--Bbar_d^0 mixing parameter r_d. The acceptable solutions closely specify the quark masses and mixings, but lie at the edges of allowed regions at 90% confidence level.Comment: 11 pages, 1 figure (not included

Family replicated fit of all quark and lepton masses and mixings

We review our recent development of family replicated gauge group model, which generates the Large Mixing Angle MSW solution. The model is based on each family of quarks and leptons having its own set of gauge fields, each containing a replica of the Standard Model gauge fields plus a (B-L)-coupled gauge field. A fit of all the seventeen quark-lepton mass and mixing angle observables, using just six new Higgs field vacuum expectation values, agrees with the experimental data order of magnitudewise. However, this model can not predict the baryogenesis in right order, therefore, we discuss further modification of our model and present a preliminary result of baryon number to entropy ratio.Comment: 13 pages, no figure, LaTeX, Talk given at 8th Adriatic Meeting and Central European Symposia on Particle Physics in the New Millennium, 4-14 Sep. 2001, Dubrovnik, Croati

Grand unification in the minimal left-right symmetric extension of the standard model

The simplest minimal left-right symmetric extension of the standard model is studied in the high energy limit, and some consequences of the grand unification hypothesis are explored assuming that the parity breaking scale is the only relevant energy between the electro-weak scale and the unification point. While the model is shown to be compatible with the observed neutrino phenomenology, the parity breaking scale and the heavy boson masses are predicted to be above 10^7 TeV, quite far from the reach of nowadays experiments. Below that scale only an almost sterile right handed neutrino is allowed with a mass M \approx 100 TeV