Proyecto de comercialización de galletas premio para canes

El presente proyecto consiste en ofrecer una solución a todas aquellas personas u hogares que consideren a un can como parte de su familia, ofreciéndole una solución a los comunes problemas que presente en el cuidado de sus mascotas, siendo el punto más importante la alimentación balanceada y nutritiva para ellos. Nuestro producto está orientado a los canes, está elaborado a base de productos naturales, no contiene preservantes y es altamente nutritivo, uno de sus beneficios más resaltantes es que ayudará a la mascota a prevenir enfermedades, como alergias o males estomacales. Se presentarán dos sabores (camote con linaza y avena con salvado de trigo), y tendrá un empaque de 500 gramos. Además, se contará con una página web y redes sociales para la toma de pedidos y serán distribuidos a domicilio. Para poder llevar a cabo este proyecto se cuenta con personas calificadas y con los suficientes conocimientos para gestionar y administrar las actividades que implica dicho negocio. Está constituido por emprendedores egresados de la Universidad de Ciencias Aplicadas en carreras como Administración de Empresas, Contabilidad y Negocios Internacionales. Finalmente, cabe recalcar que el presente proyecto tiene una vida útil de cinco años con una inversión que asciende a 301,502 soles y que la Tasa Interna de Retorno (TIR) será de 33.27%, el Valor Presente Neto 181,413.00 soles, lo que determina que es un proyecto viable y rentable.The following project’s objective is to offer a solution to people or families that consider dogs part of their families, providing a solution for all the common problems that arise when taking care of their pets, being a balanced and nourishing diet for the dog the most important issue. Guau Food is a product that is made for dogs. It is made of natural products, it does not contain any preservatives and it is highly nourishing. One of the most highlighting benefits is that it will help the pet to prevent diseases, such as allergies, stomach sicknesses, etc. When the project starts, two different flavors will be offered to the public (sweet potato with linseed and oats with wheat bran) and it will be presented in a 500 grams package. Additionally, it will have a web page and social media for ordering and the products will be home distributed. To carry out this project, we count on qualified people with enough knowledge to manage the activities that are implied on the already mentioned business. It is constituted by graduated entrepreneurs from Management, Accounting and International Business majors from the UPC. Finally, it is remarkable that the following project has a 5 year-service life with an investment amount of 301,502.00 soles. The International Rate of Return (IRR) will be 31.27% and the net present value will be 181,413.00 soles, which determines that this is a viable and profitable project.Trabajo de investigació

Role of germinal center and CD39ʰⁱᵍʰCD73⁺ B cells in the age-related tonsillar involution

Background The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes and participate as inductive organs of systemic and mucosal immunity. Based on the reduction of their size since puberty, they are thought to experience involution in adulthood. In this context, we have used tonsillar mononuclear cells (TMC) isolated from patients at different stages of life, to study the effect of ageing and the concomitant persistent inflammation on these immune cells. Results We found an age-dependent reduction in the proportion of germinal center B cell population (BGC) and its T cell counterpart (T follicular helper germinal center cells, TfhGC). Also, we demonstrated an increment in the percentage of local memory B cells and mantle zone T follicular helper cells (mTfh). Furthermore, younger tonsils rendered higher proportion of proliferative immune cells within the freshly isolated TMC fraction than those from older ones. We demonstrated the accumulation of a B cell subset (CD20⁺CD39ʰⁱᵍʰCD73⁺ cells) metabolically adapted to catabolize adenosine triphosphate (ATP) as patients get older. To finish, tonsillar B cells from patients at different ages did not show differences in their proliferative response to stimulation ex vivo, in bulk TMC cultures. Conclusions This paper sheds light on the changing aspects of the immune cellular landscape, over the course of time and constant exposure, at the entrance of the respiratory and digestive systems. Our findings support the notion that there is a re-modelling of the immune functionality of the excised tonsils over time. They are indicative of a transition from an effector type of immune response, typically oriented to reduce pathogen burden early in life, to the development of an immunosuppressive microenvironment at later stages, when tissue damage control gets critical provided the time passed under immune attack. Noteworthy, when isolated from such histologic microenvironment, older tonsillar B cells seem to level their proliferation capacity with the younger ones. Understanding these features will not only contribute to comprehend the differences in susceptibility to pathogens among children and adults but would also impact on vaccine developments intended to target these relevant mucosal sites.Instituto de Estudios Inmunológicos y Fisiopatológico