1 research outputs found
EFFECT OF SHIN'ISEIHAITO ON LUNG COLONIZATION OF PNEUMOCOCCUS IN MURINE MODEL
Background: Streptococcus pneumoniae (pneumococcus) causes various serious diseases including sinusitis, pneumonia, and meningitis. One
serious problem observed recently with pneumococcal therapy is attenuation of the antibiotic effect because of the emergence of antibiotic-resistant
pneumococcus. Shin’iseihaito, a traditional Japanese medicine based on ancient Chinese medicine, has been used for treatment of otolaryngeal
diseases in Japan. The objective of this study was to examine the anti-infectious effects of shin’iseihaito and its related mechanism.
Materials and Methods: We evaluated the beneficial effect of shin’iseihaito extract (SSHT) against pneumococcus-infected murine model. The
colonization of bacteria, blood and bronchoalveolar lavage (BAL) killing activity, the levels of inflammatory cytokine and IgA were investigated.
Results: The pneumococcus from blood was not found in both SSHT-treated mice and untreated mice. However, the pneumococcal colonization of
lung was significantly (