Enterprise Systems Manager

Presentation on the need of remote systems administration

Internet 2: Cyber Infrastructure Seminar

By bringing research and academia together with technology leaders from industry, government and the international community, Internet 2 promotes collaboration and innovation that has a fundamental impact on the future of the Internet

Linux 101: CI-trainSeminar

An overview of how the Linux operating system

Student Interactive Campus Map at Marshall University

Marshall University is a state-funded university in Huntington, West Virginia. Like many universities, it is a large organization with multiple and diverse units (colleges, departments, centers, etc.) and depends on data to run efficiently. Much of this data is used by multiple entities. To better manage the needed data collected by the university, the Marshall University Geographic Information System (MUGIS) has been developed. MUGIS will address several needs of Marshall University’s principal stakeholders. Stakeholders include the university administration, faculty, and students. One of the first applications developed for MUGIS was an interactive campus map. This Web-based application is intended to help students quickly find the location of buildings and services on the Huntington main campus. Marshall University will become a model and set the standard for the state, as no other state university has undertaken a project of this scope

Adopting Virtualized 10GBE Ethernet ISCSI SAN for Mission Critical Applications

The presentation will provide insight into the decision to move from a fibre channel SAN solution, the resulting performance metrics and financial savings seen by Marshall University. Presented at The Ohio Higher Education Computing Council (OHECC) March 23, 2011

Misleading pustular plaques of the lower limbs during Crohn's disease: two case reports

<p>Abstract</p> <p>Background</p> <p>Extraintestinal manifestations of Crohn's disease may involve the skin, the eyes, the genital mucosa, and the joints. Dermatoses associated with Crohn's disease include neutrophilic dermatoses, erythema nodosum, granulomatous dermatitis, blistering dermatoses, and non-specific skin manifestations. Cutaneous Crohn's disease is characterized by skin non-caseating epithelioid granulomatas with giant cells, remote from the gastrointestinal tract. We report herein two new cases.</p> <p>Observations</p> <p>On both patients, differential diagnosis of neutrophilic dermatoses and infectious disease were evoked, and antimicrobial agents were introduced in one of them. Given the atypical presentation, the final diagnosis of cutaneous Crohn's disease could only be made with histological examination. In patient 1, the plaques decreased in size and infiltration by more than 75% after 3 weeks of treatment with bethametasone dipropionate 0.05% cream. In patient 2, the plaques decreased by more than 50% after 6 weeks of treatment with prednisolone (45 mg/day) and azathioprine (100 mg/day).</p> <p>Discussion</p> <p>Cutaneous Crohn's disease may present as dusky, erythematous, infiltrated, and ulcerated plaques and nodules. Female-to-male sex ratio is about 2, and the mean age at onset is 35. Recurrently, the hypothesis of a skin mycobacterial or fungal infection greatly delays proper treatment. Rarity of cutaneous Crohn's disease hampers therapeutic assessment in controlled trials. Thus, available literature is limited to case reports and sparse small series, with contradictory results. These reports are subject to publication bias, and no definite evidence-based recommendations can be made on the most adequate therapeutic strategy.</p

Marshall University Institutional Repository Proposal

The purpose of this proposal is to identify the need for establishing an Institutional Repository at Marshall University to facilitate the collection, preservation, and dissemination of the intellectual output of the students, faculty, and administrative offices of the University. Institutional Repositories (IRs) provide a digital ‘storehouse’ for academic institutions to house a wide variety of scholarly material created by students, faculty, and administrators. They also provide a readily accessible depository for selected archival material, video and still images, current news and events, procedural and policy guidelines, and other information that benefits the university community and other users, including the public. The IR platform is customizable to meet the needs of the institution and provides methods to limit access to selected materials, safeguarding the stored intellectual property. Digital open access to huge amounts of material, branded to the particular institution, has the potential to reach scholarly audiences worldwide. The Ad Hoc Committee on Institutional Repositories has done extensive research to identify how other institutions are using IRs to publish, promote, and provide access to their intellectual property. The Committee has also identified a wide range of materials that are currently produced by Marshall University that could quickly and relatively easily be used to populate an IR. A suitable software platform, Digital Commons, has been identified that will provide the necessary interface to create and maintain the IR. The Committee recommends that Marshall University fund a two-year pilot program to initiate a contract with Digital Commons and create a digital Institutional Repository. The Committee additionally recommends the formation of a formal campus-wide Institutional Repository Committee comprised of faculty, students, and administrators that will develop a list of content to be posted to the IR, oversee the creation of guidelines and policies for contributions to the IR, and provide a final recommendation at the end of the pilot program on the continued efficacy of the IR

NRAS Mutation Is the Sole Recurrent Somatic Mutation in Large Congenital Melanocytic Nevi

Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation characterized by an increased risk of melanoma transformation during infancy or adulthood. NRAS and BRAF mutations have consistently been reported in CMN samples, but until recently results have been contradictory. We therefore studied a series of large and giant CMNs and compared them with small and medium CMNs using Sanger sequencing, pyrosequencing, high-resolution melting analysis, and mutation enrichment by an enhanced version of ice-COLD-PCR. Large–giant CMNs displayed NRAS mutations in 94.7% of cases (18/19). At that point, the role of additional mutations in CMN pathogenesis had to be investigated. We therefore performed exome sequencing on five specimens of large–giant nevi. The results showed that NRAS mutation was the sole recurrent somatic event found in such melanocytic proliferations. The genetic profile of small–medium CMNs was significantly different, with 70% of cases bearing NRAS mutations and 30% showing BRAF mutations. These findings strongly suggest that NRAS mutations are sufficient to drive melanocytic benign proliferations in utero

Chemical characterization of inks in skin reactions to tattoo

Skin reactions are well described complications of tattooing, usually provoked by red inks. Chemical characterizations of these inks are usually based on limited subjects and techniques. This study aimed to determine the organic and inorganic composition of inks using X-ray fluorescence spectroscopy (XRF), X-ray absorption spectroscopy (XANES) and Raman spectroscopy, in a cohort of patients with cutaneous hypersensitivity reactions to tattoo. A retrospective multicenter study was performed, including 15 patients diagnosed with skin reactions to tattoos. Almost half of these patients developed skin reactions on black inks. XRF identified known allergenic metals - titanium, chromium, manganese, nickel and copper - in almost all cases. XANES spectroscopy distinguished zinc and iron present in ink from these elements in endogenous biomolecules. Raman spectroscopy showed the presence of both reported (azo pigments, quinacridone) and unreported (carbon black, phtalocyanine) putative organic sensitizer compounds, and also defined the phase in which Ti was engaged. To the best of the authors' knowledge, this paper reports the largest cohort of skin hypersensitivity reactions analyzed by multiple complementary techniques. With almost half the patients presenting skin reaction on black tattoo, the study suggests that black modern inks should also be considered to provoke skin reactions, probably because of the common association of carbon black with potential allergenic metals within these inks. Analysis of more skin reactions to tattoos is needed to identify the relevant chemical compounds and help render tattoo ink composition safer.Peer reviewe